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| Specificity of protein-DNA |
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| interactions |
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| almost
all repressor is bound |
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| the size of the genome dilutes the ability of the |
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| repressor to bind to the specific target sites |
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| the amount of protein must be tuned to the size of the |
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| genome and the number of target sites |
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| K(rep) K(rep+inducer)
[target] |
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| 2x1013 2x1010 1 |
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| K(rep) K(rep+inducer) [all
DNA] |
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| 2x106 2x106 4x106 |
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