What the biostatistician needs to know about molecular biology
#4

Format of these lectures

Microarrays

Probes with fixed addresses are the basic elements of all arrays

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Some Affy numbers

Oligonucleotide synthesis (Agilent, Synteni, Incyte)

cDNA deposition

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Image analysis

Quantitation of Affymetrix slides

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Image analysis

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ANOVA IN ARRAY DATA MODELING

GENERAL CONCLUSIONS FROM ANOVA

CLUSTERING

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K-MEANS CLUSTERING

Hierarchical clustering

CAST (Ben-Dor)

WHICH CLUSTERING METHOD IS "BEST"?

WHICH GENES ARE UP-REGULATED?

STEP-DOWN TESTS FOR SIGNIFICANCE

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Substitutes for the t-test

What genes are useful for classification?

Classifiers

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