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largely done to estimate/mitigate pesky nuisance
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effects
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replication essential
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a typical model (two-color, Katie Kerr, Wing
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Wong):
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Yijkgr = m + Ai
+ Dj + (AD) ij + Gg
+ (AG) igr +
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(DG)jg + (CG)kg
+ sijkgr
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AD = dye-array; AG = array-gene; DG = dye-gene;
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CG = condition-gene (the interaction of interest)
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