What the biostatistician needs to know about molecular biology
#6

Format of these lectures

Outline

What are SNP's?

Slide 5

How frequent are SNP's?

Where are SNP's from?

Sampling to find SNP's

How are SNP's found?

Computational approaches to SNP discovery

Reduced-representation shotgun sequencing

TSC SNP's

Finding cSNP's

Haplotypes

Lipoprotein lipase haplotyping

Why are SNP's of interest?

SNP's and protein structure

Linkage disequilibrium

What does LD depend on?

Slide 20

Genaissance--haplotypes

Haplotypes (cont'd.)

Detecting SNP's

Finding disease-associated SNP's

Measures of disease-SNP linkage in families

Measures of SNP-disease association in populations

Four approaches to the multiple-comparison problem

Data mining for haplotypes

Conclusions-the problems with SNP's

SNP!   THE TALK IS CUT OFF HERE.