Why are SNP's of interest?
	non-synonymous cSNP's may be directly relevant to disease synonymous SNP's may affect translation efficiency (codon effect) SNP's in regulatory regions could affect transcription control or: in the presence of linkage disequilibrium, any SNP could potentially be close to a disease- or therapy-modifying gene; this could be detected by family-based studies or population-based studies (association; based on linkage disequilibrium)