SNP's and protein structure
		>80% of disease-associated SNP's affect protein stability (hydrogen bonds lost, burying of charged or polar residues, overpacking, internal cavities, breakage of disulfide bonds, disruption of metal binding, destabilization of a multimer…), with other effects (ligand binding, catalysis,…) less common (5-10%) 70% of non-disease associated SNP's have no apparent effect on protein stability or function