What the biostatistician needs to know about molecular biology
#7

Format of these lectures

Annotation defined

www.ensembl.org

The alignment problem (with gaps allowed)

The alignment problem (2)

BLAST (http://www.ncbi.nlm.nih.gov/BLAST)

BLAST (2)

Conventional Markov models

Hidden Markov models

Interpolated Markov models

Motif-finding via the Gibbs sampler (Lawrence)

Gibbs sampler (2)

Other ways of detecting protein relationships

Slide 15

Protein interaction

Slide 17

Slide 18

Protein interaction in C. elegans

Other approaches

Gene finding

Gene finding (2)

Difficulties with splicing prediction

Gene finding--state of the art

Experimental annotation with microarrays (Rosetta)

Slide 26

Slide 27

Conclusions

Conclusions (2)

This ends our discussion of the annotatome.