Biostat 580B - Statistical Genetics Seminar

Instructor: Ellen Wijsman
Instructor: Katie Kerr
Instructor: Elizabeth Thompson
Instructor: Stephanie Monks

1 credit

Autumn Quarter 2003
Seminar: Tuesday 3:45-4:45, in F643 HSB

This is a participatory seminar! Students, postdocs, faculty all present their own work and/or papers from the literature.

Remember the important questions:

Why? What? Why? How? Why? What next? and WHY?

(Why is this question important? What did they do? Why did they choose this approach? How did they do it? Why did they choose these methods? What should come next? Why is this the next logical step?)

For lists of suggested topics, click here .

Autumn 2003 SCHEDULE

Sept. 30: All

Organizational meeting. Everyone should bring a topic that they want to learn something about (relevant to statistical genetics). Please bring it written down on a piece of paper - it makes compiling the list so much easier. For previous lists, see links on this web page.
Elizabeth will announce a small competition. Also she has added an overdue update to the diallelic vs biallelic saga.

Oct 7: Ting-Yuan and Grace Ge

VJ Vieland and J Huang (2003) Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair data. Am J Hum Genet 73(2):223-232.

Oct. 14: Caroline Cutting and Bill Stewart on the topic of Map model misspecification:

Leal (2003) "Genetic Maps of Microsatellite and Single-Nucleotide Polymorphism Markers: Are the Distances Accurate" Genetic Epidemiology 24:243-252.

Oct. 21: Arindam Roy Choudhury and Garrett Hellenthal on the topic of Trait model miss-specification:

Clerget-Darpoux et al (1986) "Effects of misspecifying genetic parameters in lod score analysis" Biometrics 42:393-399

Oct. 28: Elisabeth Rosenthal: MCMC analysis of complex traits caused by multiallelic loci.

Nov. 4: Teresa Kim and Helen Kim

Multivariate models in pedigree analysis: Allison et al (1998) "Multiple Phenotype Modeling in Gene-Mapping Studies of Quantitative Traits: Power Advantages." American Journal of Human Genetics 63:1190-1201.

For a comment on negatively correlated multivariate traits, see the comment by Angel here.

Nov. 11: No seminar: Veteran's day

Nov. 18: Yun Ju Sung: "Likelihood inference for mutation accumulation experiments"

Abstract: Mutations, important in evolutionary biology, are studied in mutation accumulation experiments. Statistical inference for these experiments is very difficult because mutations aren't directly observable. We proposed a new Monte Carlo method for likelihood inference in general missing data models. The talk will describe our experience developing computer programs applying our method to these experiments.

Nov. 25: Audrey Fu and Paul Scheet

Multivariate trait models in pedigree analysis (cont). Amos CI, de Andrade M, Zhu DK (2001) Comparison of multivariate tests for genetic linkage. Human Heredity 51:133-144.

Dec. 2: Angel Wan: "Comparison of multivariate linkage approaches using variance components"

Dec. 9: Weiva Sieh and Joe Rothstein

Risch N, Giuffra L. Model misspecification and multipoint linkage analysis. Hum Hered 1992;42:77-92. (Note: this is pre-electronic edition. Make a copy from the paper in the biostat or stat folder).

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