Coordinator: Sharon Browning sguy@uw.edu
Sept 30: Introductions and organizational meeting
Oct 7: Joshua Akey, Li Jin and Momiao Xiong. Haplotypes vs single marker linkage disequilibrium tests: what do we gain? European Journal of Human Genetics (2001) 9, 291-300. http://www.nature.com/ejhg/journal/v9/n4/pdf/5200619a.pdf
Presenters: Alice, Kelsey, (Ellen)
Oct 14: Jung-Ying Tzeng, B. Devlin, Larry Wasserman and Kathryn Roeder. On the Identification of Disease Mutations by the Analysis of Haplotype Similarity and Goodness of Fit. Am. J. Hum. Genet. 72:891–902, 2003. http://www.sciencedirect.com/science/article/pii/S0002929707606119#
Presenters: Brenton, Bowen, Jesse, (Sharon)
Oct 21: (ASHG – Sharon will be absent) JM Chapman, JD Cooper, JA Todd, DG Clayton. Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered 2003;56:18–31 http://www.karger.com/Article/Pdf/73729
Presenters: Yatong, Yicheng, Fiona, (Tim)
Oct 28: ASHG reports
Presenters: All those who attended the ASHG conference
Nov 4: Sharon R. Browning. Multilocus Association Mapping Using Variable-Length Markov Chains. Am. J. Hum. Genet. 2006;78:903–913. http://www.sciencedirect.com/science/article/pii/S0002929707639135
Presenters: Aaron, Alden, Lisa, (Liz)
Nov 11: Veterens Day, no class
Nov 18: Qian S Zhang, Brian L Browning and Sharon R Browning. Genome-wide haplotypic testing in a Finnish cohort identifies a novel association with low-density lipoprotein cholesterol. European Journal of Human Genetics, in press. http://www.nature.com/ejhg/journal/vaop/ncurrent/full/ejhg2014105a.html
Presenters: Qian, Xiaowen, Brenda (Sharon)
Nov 25: J Marchini and B Howie. Genotype imputation for genome-wide association studies. Nature Reviews Genetics 2010 11:499-511. http://www.nature.com/nrg/journal/v11/n7/pdf/nrg2796.pdf Pay particular attention to the section on “Association testing using imputed data”.
Presenters: Joey, Caitlin, Jeremy, Nan (Tim)
Dec 2: Melanie Bahlo from the Walter and Eliza Hall Institute of Medical Research in Melbourne will be speaking.
Omitted: CJ Willer et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nature Genetics 2008. http://www.nature.com/ng/journal/v40/n2/pdf/ng.76.pdf
Omitted: The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature 2012. http://www.nature.com/nature/journal/v491/n7422/full/nature11632.html Pay particular attention to the section on “Uses of 1000 Genomes Project data in medical genetics”