The topic this quarter is "classic population genetics". I have chosen a selection of papers published between 1964 to 2002. All these papers have been highly impactful, and have each been cited over 1000 times. I have added a very short description below each listed paper.

See the course website https://canvas.uw.edu/courses/1396064 for more details including the Tuesday zoom links. If you don’t have access to the course website, please contact Sharon Browning (mailto:sguy@uw.edu).

Week 1 (October 6)

Lewontin, R.C., 1964. The interaction of selection and linkage. I. General considerations; heterotic models. Genetics, 49(1), p.49. 

Linkage disequilibrium as a function of selection and recombination rates. Introduces D’.

Week 2 (October 13)

Kimura, M. and Crow, J.F., 1964. The number of alleles that can be maintained in a finite population. Genetics, 49(4), p.725. 

The infinite alleles model, effective size, and equilibrium levels of heterozygosity.

Week 3 (October 20)

Ewens, W.J., 1972. The sampling theory of selectively neutral alleles. Theoretical population biology, 3(1), pp.87-112. 

Ewens sampling formula: Provides a distribution for the counts of alleles seen in a sample, and a formula for estimating the scaled mutation rate.

Week 4 (October 27)

Lewontin, R.C. and Krakauer, J., 1973. Distribution of gene frequency as a test of the theory of the selective neutrality of polymorphisms. Genetics, 74(1), pp.175-195. 

F_ST: Test for selection by using degree of population differentiation at a locus.

Optional: See Beaumont 2005 for a review. 

Week 5 (November 3)

Weir, B.S. and Cockerham, C.C., 1984. Estimating F-statistics for the analysis of population structure. Evolution, pp.1358-1370. 

Provides a solid statistical grounding for estimating F_ST.

Week 6 (November 10)

Smith, J.M. and Haigh, J., 1974. The hitch-hiking effect of a favourable gene. Genetics Research, 23(1), pp.23-35. 

Genetic hitch-hiking due to selection at a linked locus.

Week 7 (November 17)

Kingman, J.F., 1982. On the genealogy of large populations. Journal of applied probability, pp.27-43. 

Kingman’s coalescent.

Week 8 (November 24)

Tajima, F., 1989. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics, 123(3), pp.585-595.

Tajima’s D. Test for selection using the spectrum of allele frequencies at a locus.

Week 9 (December 1)

McDonald, J.H. and Kreitman, M., 1991. Adaptive protein evolution at the Adh locus in Drosophila. Nature, 351(6328), pp.652-654. 

McDonald-Kreitman test: Test for selection using ratio of non-synonymous to synonymous substitutions (dN/dS).

Week 10 (December 8)

Sabeti, P.C., et al., 2002. Detecting recent positive selection in the human genome from haplotype structure. Nature, 419(6909), pp.832-837. 

Extended haplotype homozygosity (EHH): Test for selection by looking for an excess of long shared haplotypes at a locus.