Fall Quarter 1997

Sept 30:

Introduction

Kruglyak, :The Use of a Genetic Map of Biallelic Markers in Linkage Analysis", Nature Genetics 17:21-24, 1997.
Discussion Leader: Katrina Goddard

Is it diallelic or biallelic?

Disequilibrium Mapping via Coalescent Models of Gene Ancestry
Discussion Leader: Jinko Graham

Optimal Marker Characteristics for Genome Screens Using Linkage Disequilibrium Tests
Discussion Leader: Nicky Chapman

The proceedings of the 12/95 meeting in Oxford on Genetics Mapping of Disease genes (Chapter 10), Academic Press, I.H. Pawlowitzki and J.H. Ewards eds.
(Ask Elizabeth for reprints if you are interested)

When is linkage analysis "nonparametric"?
In mapping complex traits, linkage analysis methods that incorporate a specific model for the trait have often been unsuccessful, since the trait model assumptions obscur the linkage information. However, so-called "non-parametric" methods of linkage detection have also often been unsuccessful, perhaps because they lack power. To map complex traits successfully we need methods that have power, but which are not sensitive to trait model assumptions? Can we achieve a successful balance between power and robustness? How? What sampling designs?
Discussion Leader: Elizabeth Thompson

Heath S., "Markov Chain Monte Carlo Segregation and Linkage Analysis for Oligogenic Models", Am. J. Hum. Gen. 61:748-760, 1997.
Multipoint Oligogenic Analysis of Age of Onset Data with Applications to Large Alzheimer Disease Pedigrees.
Discussion Leader: Warwick Daw

University Holiday. No Class.

Joint Linkage and Segregation Analysis: an MCMC Multipoint Approach
Discussion Leader: Greg Snow

Models of Meiotic Exchange and Observed Patterns of Recombination

Lamb, Feingold, and Sherman, "Estimating Meiotic Exchange Patterns From Recombination Data: An Application to Humans" Genetics 146: 1011-1017 1997

Discussion Leader: Jochen Kumm

ML-estimation of population parameters in geographically structured populations
For some crude overview people could peek into the documentation for the 2-population case (program MIGRATE on http://evolution.genetics.washington.edu/lamarc.html ).
Discussion Leader: Peter Beerli

These pages are Copyright © 1994, 1995, 1996 by University of Washington, including all images and photographs (of more than 20,000 pixels in size) unless otherwise noted.