Biostat 580B - Statistical Genetics Seminar

Instructor: Ellen Wijsman
Instructor: Elizabeth Thompson

1 credit

Spring Quarter 2002
Seminar: Tuesday 4:00-5:00, in F643 HSB (biostatistics conference room)

Remember the important questions:

Why? What? Why? How? Why? What next? and WHY?

(Why is this question important? What did they do? Why did they choose this approach? How did they do it? Why did they choose these methods? What should come next? Why is this paper important? )

Reminder: Everyone should read the papers for weeks in which we read a journal article. If the paper is available electronically, we will provide the reference, and you may download your own copy from the healthlinks web site, or through the UW e-journals page.
If the paper is not available electronically, the discussion leaders should make 2 copies, and should put one copy in each of the stat mailbox and the biostat 580B homework folder, preferably a week ahead of time. The stat mailbox is in the mail room in statistics; the biostat 580B homework folder is in the top left drawer underneath the biostat mailboxes in a folder to the far left as you face the mailboxes. Others should then make their copies from one of these two copies.

Discussion leaders are only expected to spend 20-30 minutes (jointly) presenting the assigned paper(s). If you don't understand everything, focus on what you can, and try to think about what is important about the papers, and what open questions you are left with.
MAKE SURE YOU LEAVE ADEQUATE TIME FOR DISCUSSION.

• list of suggested topics collected Oct. 2, 2001
• list of papers considered in Spring 2001
• list of suggested topics collected Sept. 26, 2000

Spring 2002 SCHEDULE

April 2: Paul Scheet and Peter Mork

• Lon R. Cardon & John I. Bell (2001)
  ASSOCIATION STUDY DESIGNS FOR COMPLEX DISEASES
  Nature Reviews Genetics 2, 91-99

April 9: Saonli Basu and Bill Stewart

• Terwilliger et al., Human Hered (1998), 48: 138-154

April 16: Elizabeth Thompson

• Topic: EMGM, GAW and IGES -- 30 years of Statistical Genetics
  There will also be time to set the schedule for the last 6 weeks: unless there are other suggestions we will continue with the two themes of complex traits and linkage disequilibrium (separately or together),

April 23: Anne-Louise Leutenegger

• Topic: Anne-Louise will talk on the topic of her recently submitted MLS paper

April 30: Xuesong Yu, Michael Li

• Mark Abney, Carole Ober and Mary Sara McPeek (2002)
  Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites.
  AJHG, 70: 920-934

May 7: Solly Sieberts, Grace Ge

• Jinming Li, Stephanie L. Sherman, Neil Lamb, and Hongyu Zhao (2001)
  Multipoint Genetic Mapping with Trisomy Data
  Am. J. Hum. Genet., 69:1255-1265
  

May 14: Dongmei Yu

• T.H.E. Meuwissen and M.E. Goddard (2000)
  Fine mapping of quantitative trait loci using linkage disequilibria with closely linked marker loci. Genetics 155:421-430.
  (This was Dongmei's STAT551 project paper, which she could not present last quarter. Is there anyone not yet signed up who would like to join Dongmei and present either some background or some follow-up for this paper?)

May 21: Amy Anderson, Lixuan Qin

• Majewski H., Hao L. and J. Ott (2001)
  The Ising Model in Physics and Statistical Genetics.
  Am J Hum Genet 69:853-862

May 28: Elisabeth Rosenthal, Joe Rothstein

• Jonathan K. Pritchard (2001)
  Are Rare Variants Responsible for Susceptibility to Complex Diseases?
  Am. J. Hum. Genet., 69:124-137

June 4: Zheng Zhang, Lance Jolley (Probable paper choice)

• Wright A, Carothers A, Pirastu M (1999)
  Population choice in mapping genes for complex diseases
  Nat Genet 1999 Dec; 23(4) 397-404

Other suggested papers

• PM McKeigue (1997) Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations. Am J Hum Genet 60: 188-196.
• PM McKeigue (1998) Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture. Am J Hum Genet 63(1):241-251
  We did do this one in Winter 2000 -- however there has been quite a lot of turnover in StatGen since then -- and those who remember it can assist the discussion.
• A.P. Morris, J.~C. Whittaker and D.~J. Balding (2002): suggested by Michael
  Fine-scale mapping of disease loci via shattered coalescent modeling of genealogies.
  AJHG, 70: 686-707.
• Regression Models for Linkage Heterogeneity Applied to Familial Prostate Cancer Daniel J. Schaid, Shannon K. McDonnell, and Stephen N. Thibodeau Am. J. Hum. Genet., 68:1189-1196, 2001
• A Confidence-Set Approach for Finding Tightly Linked Genomic Regions Shili Lin, James A. Rogers, and Jason C. Hsu Am. J. Hum. Genet., 68:1219-1228, 2001
• Problems in the Definition, Interpretation, and Evaluation of Genetic Heterogeneity Alice S. Whittemore and Jerry Halpern Am. J. Hum. Genet., 68:457-465, 2001

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