Biostat 580B - Statistical Genetics Seminar

Spring Quarter 2006
Seminar: Tuesday 4:00-5:00, Now back in F643 HSB


March 28 Organizational meeting. Bring, written down on a piece of paper, general topic(s) you would be interested in reading about that are pertinent to the broad field of statistical genetics. If you have any specific articles from the literature to suggest, write those down as well. We will (as usual) pick one or more areas for literature review, for weeks in which we do not have a research presentation, and we will set up the rest of the quarter's schedule.

April 4 Joe Rothstein
Joe will talk about his M.S. thesis work on evaluating Monte Carlo methods for accurate estimation of linkage lod scores.

April 11 Garrett Hellenthal and Grace Ge
Brem & Kruglyak (2005) "The landscape of genetic complexity across 5,700 gene expression traits in yeast"
PNAS 102:1572-1577 and
Schadt, Monks, et al (2003) "Genetics of gene expression surveyed in maize, mouse, and man"
Nature 422:297-301
(Added note: The earlier Brem, Yvert, Clinton and Kruglyak (2002), Science 296: 752-755, may be an easier intro to the yeast expression mapping stuff.)

April 18 Eric Rynes and Paul Scheet
Storey JD, Akey JM, and Kruglyak L. (2005)
Multiple locus linkage analysis of genomewide expression in yeast.
PLoS Biology, 3(8): 1380-1390.

April 25 Yunju Sung: research talk.
Gene-gene interaction in linkage analysis on general pedigrees. component on general pedigrees.

May 2 Amy Anderson and Audrey Fu
Kruglyak L, Daly MJ, Reeve-Daly MP and Lander ES (1996)
Parametric and nonparametric linkage analysis: a unified multipoint approach.
AJHG 58: 1347-1363.
(This paper predates the online AJHG: Audrey will put copies in Stat and Biostat statgen mail-boxes.
There is now a NEW "purple folder" in Biostat.)

Friday, May 5: see related announcements below.

May 9 Yanming Di and Elisabeth Rosenthal
Konstantin Strauch, Rolf Fimmers, Max P. Baur, Thomas F. Wienker (2003)
How to Model a Complex Trait. 2. Analysis with Two Disease Loci
Human Heredity 56: 200-211.

May 16 Josh Sampson and Adele Mitchell
Schmidt S. et al. (2006)
Cigarette Smoking Strongly Modifies the Association of LOC387715 and Age-Related Macular Degeneration.
Am J Hum Genet 78:852-864

May 23 Yoonha Choi and Arindam RoyChoudhury.
Anttila et al. (2006) Trait Components Provide Tools to Dissect the Genetic Susceptibility of Migraine
Am J Hum Genet 79: ????

Here is another interesting paper, that we also considered.
A Novel Framework for Sib Pair Linkage Analysis (Poznik et al. 2006, AJHG) .abstract.htm

Wednesday, May 24: See related announcements below.

May 30 Weiva Sieh: Research talk
Mapping the gene(s) for amyotrophic lateral sclerosis/parkinsonism dementia complex of Guam: challenges and approaches to linkage analysis of a large complex pedigree.

Other related announcements:

May 5: UW Recombination Workshop

May 24: Genome Sciences 5 th. Annual Symposium