Biostat 580B - Statistical Genetics Seminar
1 credit
Spring Quarter 1999
Seminar: Tuesday 4:00-5:00 F-600 Biostatistics conference room
Reminder: Everyone should read the papers (make a copy from the copy left in
the stat mailbox, or the purple biostat 580B homework folder under the biostat
mailboxes). Discussion leaders are only expected to spend 15-20 minutes
presenting the assigned papers. If you don't understand everything, focus on
what you can, and try to think about what is important about the papers, and
what open questions you are left with.
Remember the important questions:
Why? What? Why? How? Why? What next? and WHY?
Spring Schedule
March 30:
Lindsey Dubb (originally scheduled for Feb 23).
Roderic D. M. Page, Michael A. Charleston (1997), From Gene to
Organismal Phylogeny: Reconciled Trees and the Gene Tree/Species Tree
Problem, Molecular Phylogenetics and Evolution 7(2) pp231-240.
Also in the stat and biostat boxes is a Trends in Ecology and Evolution
paper. The article has a box which
covers (some of) the terminology:
Page, Roderic D.M., and Michael A. Charleston (1998), Trees within
trees: phylogeny and Historical associations, Trends in Ecology and
Evolution ("TREE") vol 13(9) pp 356-359.
April 6: Jochen Kumm
Kruglyak-L. and Lander-E-S.
Faster multipoint linkage analysis using Fourier transforms.
JOURNAL OF COMPUTATIONAL BIOLOGY 1998. 5(1) P 1-7.
We also set the schedule for the rest of the quarter at this 3/30 mtng:
we are going to learn some quantitative genetics!!
April 13;
Laura Schorenberg and Nicky Chapman
Basics of genetic components of variance, additive and dominance effects.
For example: Chapters 7,8 of Falconer (old edition)
April 20: France Gagnon and Jochen Kumm
Heritabilities and correlations between relatives
For example: Chapters 9,10 of Falconer (old edition)
April 27: Do Peterson
"Maximum Likelihood Mapping of Quantitative trait Loci Using Full-Sib
Families," Knott and Haley. Genetics 132:1211-1222 (Dec, 1992).
May 4: Ellen Goode
Quantitative traits in sib pairs
Haseman JK, Elston RC (1972)
The investigation of linkage between a quantitative trait and
a marker locus.
Behav. Genet. 2:3-19.
Wilson AF et al. (1988)
LInkage of a gene regulating dopamine-beta-hydroxylase activity
and the ABO blood group locus.
Am J Hum Genet 42:160-166.
May 11: Warwick Daw
Partitioning variance for an oligogenic quantitative trait.
Warwick will discuss a recent real-data application, analyzing variance
due to genetic effects on age-of-onset in Alzheimer's disease, with
covariates.
May 18: Lindsey Dubb
Mitchell-Olds, Thomas, and J.J. Rutledge. 1986.
Quantitative Genetics in Natural Populations: A Review of the Theory.
The American Naturalist V127(3) pp. 379-402.
A second paper is also from Mitchell-Olds.
It's available
online
from computers at the UW.
May 25: Eric Anderson
Lande, Russell
The minimum number of genes contributing to quantitative trait variation
between and within populations.
Genetics, 99: 541-553.
June 1: Barbara McKnight
Cannon TD, Kaprio J, Lonnqvist J, Huttunen M, Koskenvuo M (1998) The
genetic epidemiology of Schizophrenia in a Finnish twin cohort: A
population-based modeling study. Arch Gen Psychiatry 55 pp67-74.
Also chapter 7, (pp200-232) from Fundamentals of Genetic
Epidemiology, Khoury MJ, Beaty TH and Cohen BH., Oxford 1993.
http://www.biostat.washington.edu/biostat/classes/biostat580B
Last updated: Mar. 29, 1999
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