Biostat 580B - Statistical Genetics Seminar

Instructor: Ellen Wijsman
Instructor: Elizabeth Thompson

1 credit

Winter Quarter 2000
Seminar: Tuesday 4:00-5:00 F-600 Biostatistics conference room

Winter 2001 SCHEDULE

Jan. 2:

NO MEETING

Jan. 9:

Erin Conlon will talk about a project on array data that she worked on while she was attending the functional genomics course at UCLA during fall quarter.

A related article which you should try to read is: Bittner et al (2000) Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406:536-540.

Jan. 16:

Lindsey Dubb and Elisabeth Rosenthal:
Kong A and Cox NJ (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61:1179-1188.

Jan 23:

Paul Scheet and Solly Sieberts:
Cox NJ et al. (1999) Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nature Genetics 21:213-215.

Jan 30:

Anne-Louise Leutenegger and Nicky Chapman:
Horikawa Y et al. (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nature Genetics 26:163-175.

Feb 6:

Michael Li & Kristian Lynch:
McPeek MS and Strahs A (1999) Assessment of linkage disequlibrium by the decay of haplotype sharing with application to fine-scale genetic mapping. Am J Hum Genet 65:858-875. You can retrieve a copy of this paper from the web at: http://www.journals.uchicago.edu/AJHG/journal/issues/v65n3/981087/981087.html

and you can find a list of errata and typos at: http://galton.uchicago.edu/~mcpeek/research/DHS.errata.and.typos

Feb 13:

Ellen Wijsman: will give the talk she will be presenting at the Gordon conference on quantitative biology.

Feb 20:

Amy Anderson & Bill Stewart:

Ben-Dor A et al. (2000) Universal DNA Tag Systems: A Combinatorial Design Scheme. J Comput Biol 7 (3-4): 503-519.

Here's a brief description: There has been a recent suggestion that life might be better if, instead of using DNA arrays custom designed for an experiment, there were Universal DNA Arrays that could be used. The use of a universal DNA chip has two advantages: first, such chips could be made cheaply (mass produced), and second, hybridizations that are delicate (high chance of cross hybridization) would be made in solution where conditions can be more easily made to be unfavorable for cross hybridization.

This paper explains how one might design such a Universal Array.

Feb 27:

Eric Anderson and Saonli Basu: (papers are in folders)
Navidi, W and N. Arnheim (1999) Combining data from polymerase chain reaction DNA typing experiments: applications to sperm typing data. JASA 94:726-733.

Leeflang et al (1995) Single sperm analysis of the trinucleotide repeats in the Huntington's disease gene: quantification of the mutation frequency spectrum. Human Molecular Genetics 4(9):1519--1526.

Mar 6:

Do Peterson and Hao Liu

HJ Cordell, GC Wedig, KB Jacobs and RC Elston. Multilocus linkage tests based on affected relative pairs. Am J Hum Genet 66(4):1273-1286 (2000)

For Links to other seminars of interest this quarter at the UW
click here.
Feb 5: Chris Triggs, whom we welcome back to the Stat Dept and the StatGen seminar for the next six months, will be giving the Stat Dept seminar on Feb 5, 2001.

For any potential StatGen postdocs (US citizens or green-card holders only):
The Genome Training Grant, which now contains a designated Statistical Genetics component, is advertising for potential postdocs. Anyone interested, please see one of the GTG Statistical Genetics faculty. Feel free to pass on this message. (Unfortunately the GTG does not have a web page (yet).)

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