Biostat 580B - Statistical Genetics Seminar

Jan 11: Ellen Wijsman

• The Number of Trait Loci in Late-Onset Alzheimer Disease.
  E. Warwick Daw, Haydeh Payami, Ellen J. Nemens, David Nochlin, Thomas D. Bird, Gerard D. Schellenberg, and Ellen M. Wijsman.
  American Journal of Human Genetics, 66: 196--204. (January 2000)
• Evidence for a Novel Late-Onset Alzheimer Disease Locus on Chromosome 19p13.2.
  Ellen M. Wijsman, E. Warwick Daw, Change-En Yu, Haydeh Payami, Ellen J. Steinbart, David Nochlin, Erin M. Conlon, Thomas D. Bird, and Gerard D. Schellenberg Wijsman et al.
  American Journal of Human Genetics, 75: 398--409. (July 2004)

Jan 18: Audrey Fu and Liping Tong

• Model choice in Gene Mapping
  M.J.Silanpaa and J. Corander
  Trends in Genetics 18: 301-307 (June 2002)

Jan 25: Garrett Hellenthal and Yoonha Choi
The topic is censored data/phenotypes. The paper is:

• Li HZ
  An additive genetic gamma frailty model for linkage analysis of diseases with variable age of onset using nuclear families
  LIFETIME DATA ANALYSIS 8 (4): 315-334 DEC 2002

Feb 1: Haoyuan Zhu and I-Yu Chiu
The topic is penetrance, in context of complex traits. We have both a general paper, and an example from a few pages of a more complex example:

• E, M Wijsman. What is Penentrance?
• Sebastian Zollner and Jonathan K Pritchard
  Coalescent-based association mapping and fine mapping of complex trait loci
  Genetics 2004, October 16: doi: 10.1534/genetics.104.031799.
  Note: the example of Pp. 13-17 ONLY

Feb 8: Grace Ge and Paul Scheet
The topic is models for longitudinal data. The first paper following is the methodology paper underlying two of the longitudinal data analyses of the Framingham data in GAW13 (by some of the same authors): these GAW13 refs are also given FYI.

• Scurrah, K.J., Palmer, L.J., Burton P.R. 2000 Variance components analysis for pedigree-based censored survival data using generalized linear mixed models (GLMMs) and Gibbs sampling in BUGS. Genet Epidemiol, 19:127-148.
• Scurrah, K. J., Tobin, M. D., Burton, P. R. 2003 Longitudinal variance components models for systolic blood pressure, fitted using Gibbs sampling. BMC Genetics 4(Suppl 1):S25.
• Palmer, L.J., Scurrah, K.J., Tobin, M., Patel, S.R., Celedon, J.C., Burton, P.R., Weiss, S.T. 2003 Genome-wide linkage analysis of longitudinal phenotypes using s2A random effects (SSARs) fitted by Gibbs sampling. BMC Genetics 4(Suppl 1): S12

See this page from Charlie re what methacholine is and does

See these pages from Charlie, clarifying the methodlogical issues

Feb 15: Joe Rothstein and Julian Wolfson
Topic: Major gene covariates:

• D. CURTIS, B. V. NORTH, P. C. SHAM, 2001
  A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease
  Annals of Human Genetics 65 (5) 473--

Add codes for next quarter: please contact Katie Kerr (katiek@u)-- soon, not quite yet, I think!

Feb 22: Arindam RoyChoudhury and Saonli Basu
Topic: Missing phenotypes and covariates.
Here is one brief overview paper:

• Chao Xing, F R Schumacher, D V Conti and John S Witte, 2003
  Comparison of missing data approaches in linkage analysis
  BMC Genetics 4 (Suppl 1): S44 (Genetic Analysis Workshop 13)

• Roderick J.A. Little, Donald B. Rubin (2002)
  Statistical analysis with missing data
  Wiley, New York.

Mar 1: Rob Igo : research talk.

Mar 8: Angel Wan : research talk.