Winter Quarter 1997

January 7:
Topic: Oligogenic mapping with MCMC methods
Discussion leader: Simon Heath


January 14:

Topic:
Botstein D, White RL, Skolnick M, Davis RW, "Construction of a genetic Linkage map in man using restriction fragment length polymorphisms", Am J Hum Genet 32:314-331, 1980.

Kan YW, Dozy AM, "Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation", PNAS 75(11):5631-5, 1978.

Discussion Leaders: Ellen Goode, Eric Anderson

January 21:

Topic:
Jeffreys, Wilson, and Thein, "Hypervariable 'minisatellite' regions in Human DNA", Nature 314:67-73, 1985.

Nakamura et al., "VNTR Markers for Human Gene Mapping", Science 235:1616-1622, 1987.

Discussion Leaders: Sharon Guy and Beatrix Jones

January 28:

Topic:
PCR
Mullis, "The unusual origin of the polymerase chain reaction", Scientific American 56-65, April 1990.

Saiki et al., "Enzymatic Amplification of beta-globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia", Science 230:1350-1354, 1985.

Microsatellite markers
Weber and May, "Abundant Class of Human DNA Polymorphisms which can be Typed using the Polymerase Chain Reaction", Am J Hum Genet 44:388-396, 1989

Discussion Leaders: Ellen Wijsman

February 4:

Topic:
Chee et al., "Accessing Genetic Information with High-Density DNA Arrays", Science 274:610, Oct. 26, 1996.

Hacia et al., Detection of Heterozygous Mutations in BRCA1 using High Density Oligonucleotide Arrays and Two-Colour Fluorescence Analysis", Nature Genetics 14:441, December 1996

Discussion Leaders: Nicky Chapman


February 11:

Topic: Genomic Mismatch Scanning
Nelson, S. F. et al, Genomic Mismatch Scanning: A New Approach to Genetic Linkage Mapping. Nature Genetics 4:11-18, 1993.

Brown P., Genome Scanning Methods, Current Opinion in Genetics and Development, 4:366-373, 1994.

Feingold, E. (1993) Markov Processes for Modeling and Analyzing a New Genetic Mapping Method. J. Appl. Prob. 30, 766-779.

Thomas, A. et al (1994) Genomic Mismatch Scanning in Pedigrees. IMA Journal of Mathematics Applied in Medicine and Biology, 11, 1-16.

Discussion Leaders: Jinko Graham and Sharon Guy

February 18:

Topic: Trait Markers for Alcoholism

Discussion Leaders: Warwick Daw

February 25:

Topic: RAPDs
WILLIAMS et al.,"DNA polymorphisms amplified by arbitrary primers are useful as genetic markers.", Nucleic Acids Research 18:6531-6535, 1990.

Discussion Leaders: Elizabeth Thompson

March 4:

Topic: Possible Issues in using new Mol. Bio. Techniques

Discussion Leaders: Ellen Wijsman

March 11:

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