POSSIBLE NEW TOPICS

• Foundation papers in statistical genetics
  
• Different study designs: practical details, constraints etc.
  
• A (real-life) case-study, e.g. from segregation to association
  
• Hap-map project, haplotype blocking, tagging SNPs. One possibility: Dana C. Crawford, Christopher S. Carlson, Mark J. Rieder, Dana P. Carrington, Qian Yi, Joshua D. Smith, Michael A. Eberle, Leonid Kruglyak, and Deborah A. Nickerson (2004) Haplotype Diversity across 100 Candidate Genes for Inflammation, Lipid Metabolism, and Blood Pressure Regulation in Two Populations. Am J Hum Genet 74:610-622
  
• Ascertainment
  
• Incorporating known biology into statistics. One possibility: Mark A. Beaumont, Bruce Rannala (2004) The Bayesian revolution in genetics. Nat Rev Genet 5:251-261.
  
• Models for human disease (what has been used, what makes a good model, what are the current issues, what is a bad/inadequate model). One possibility: Rat Genome Sequencing Project Consortium (2004) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428:493-521
  
• Unusual models of transmission and what tests can detect them, e.g. mitochondrial inheritance, X-chromosome. Possibilities: Shete S, Amos CI (2002) Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting. Am J Hum Genet 70(3):751-7 or Shete S, Zhou X, Amos CI (2003) Genomic imprinting and linkage test for quantitative-trait Loci in extended pedigrees. Am J Hum Genet 73(4):933-8
  
• History of statistical genetics brief synopsis highlights