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Bioen 599 F, Autumn 2000 Bioengineering Principles of Physiology |
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Lecture Material and Notes Week 3, Lecture 8: Processes
that use chemical potential energy Lecture theme and outline: · General principle of coupling chemical energy: energonic processes driven by coupling to exergonic ones. · Molecular motors utilize chemical energy in the form of ATP. · ATP is the universal energy motif in cells, the universal coinage of the cellular realm. · Nature of large free energy available from ATP; some chemistry and thermodynamics · Actomyosin ATPase. · Ion pumping ATPase, especially Ca++ and Na+. · Housekeeping processes (DNA synthesis and RNA transcription, protein translation, protein degradation, signaling and information transfer i.e. cellular computation) are all a much smaller requirement for energy quantitatively. · Energy storage is limited; most cells have only a few minutes worth of immediately available energy. · Consequences of running out of energy: without energy they stop. Reading: 1. Alberts Textbook Chapter 2 focusing on pages 60 - 88; and Chapter 3 pages 95 to 98 on energy overview. 2. Meyer, R. A., and J. M. Foley. Cellular Processes Integrating the Metabolic Response to Exercise. In: Handbook of Physiology., edited by L. B. Rowell and J. T. Shepherd, New York: Oxford University Press, 1996, p. 841-869. 3. Kushmerick, M. J. Energetics of muscle contraction. In: Handbook of Physiology, Skeletal Muscle, edited by L. Peachey, R. Adrian and S. R. Geiger. Bethesda, MD: American Physiological Society, 1983, p. 189-236. 4. Alberts textbook chapter 14, pages 653 - 684 (omit details from 676-80) |
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Contact the instructor at: kushmeri@u.washington.edu
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