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Bioen 599 F, Autumn 2000 Bioengineering Principles of Physiology

Lecture Material and Notes

Week 3, Lecture 9: Processes that generate chemical potential energy
Martin Kushmerick

Lecture theme and outline: · Absolute requirement for steady state function is continuous generation of ATP. · Chemical capacitance in nerves and muscles in the form of PCr and creatine kinase; analogy with electrical capacitance as storage of energy; output of current (chemical flux) is a dissipation that reduces potential. · Metabolic systems; catabolism of carbohydrate and fats produce ATP. · Oxidative processes dominate mammalian systems; nature of oxioreduction - a bit more chemistry. · Mitochondrial oxidative phosphorylation. · Glycolylsis. · Storage forms for metabolism: glycogen and triglyceride inside cells. · Transient ability to function as a closed system. · Therefore, open systems are needed for longer term steady state function.

Readings:

See Lecture 8.

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 Last Updated:
10/06/00

Contact the instructor at: kushmeri@u.washington.edu