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Bioen 599 F, Autumn 2000 Bioengineering Principles of Physiology |
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Lecture Material and Notes Week 5, Lecture 13: New
methods and insights into muscle contraction Lecture theme and outline: What are the most fundamental predictions of the view of the molecular basis of muscle contraction presented so far? Predictions to consider: Filament lengths should remain constant during contraction; cross-bridge structure appropriate to allow for cross-bridge cycling; cross-bridges should be confirmed to rotate; stochastic behavior of bridges should be reflected in mechanics; tension should be proportional to overlap of thick/thin filaments; cross-bridge action should lead to a stable sarcomere; one ATP anticipated per cross-bridge cycle. Evidence bearing on these issues will be presented, along with the kinds of techniques that engineers have devised to gather such evidence. Reading: Pollack, 1990 book, Chapters 1-4 |
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Contact the instructor at: ghp@u.washington.edu
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