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Lecture
Material and Notes
Week 8, Lecture 21:
Simulations of Ca++ transport and EC coupling
Paolo Vicini
Lecture theme and
outline: Cellular Ca regulates contraction and is crucial to
understanding cardiac muscle contraction. Variations in this Ca balance
influence both physiological and pharmacological mechanisms that change
cardiac contraction and for pathological states (arrhythmias) · Examples
of recent kinetic models and their role in increasing system understanding
:
- A computer model for Ca2+
release from the sarcoplasmic reticulum (Glukhovsky)
- A detailed model of
excitation-contraction in cardiac muscle (Winslow)
- The Bers-Puglisi computer
simulation model
- A model of Ca2+ handling
by mitochondria in the pancreatic beta-cell obtained by arranging in a
modular fashion proton pumping via respiration and proton uptake, a
proton leak, adenine nucleotide exchange, the Ca2+ uniporter, and
Na+/Ca2+ exchange: model building and evaluation (Keizer)
Suggested reading:
- Chapter 15, 743-752 (Ca2+
as an intracellular signal)
- Winslow RL, Rice J, Jafri
S, Marban E, O'Rourke B. Mechanisms
of altered excitation-contraction coupling in canine tachycardia-induced
heart failure, II: model studies. Circ Res. 1999 Mar
19;84(5):571-86.
- Glukhovsky A, Adam DR,
Amitzur G, Sideman S. Mechanism
of Ca++ release from the sarcoplasmic reticulum: a computer model.
Ann Biomed Eng. 1998 Mar-Apr;26(2):213-29.
- Eduardo Ríos and Michael
D. Stern. Calcium
in Close Quarters: Microdomain Feedback in Excitation-Contraction
Coupling and Other Cell Biological Phenomena. Annu. Rev. Biophys.
Biomol. Struct. 1997. 26:47-82.
- Magnus G, Keizer J.
Minimal model of beta-cell mitochondrial Ca2+ handling. Am J Physiol.
1997 Aug;273(2 Pt 1):C717-33.
Examples of sites on the
Hodgkin-Huxley model:
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