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Lecture
Material and Notes
Week 10, Lecture 27:
Models of Energy Balance
Paolo Vicini
Lecture theme and outline:
fitting a model to data to investigate aspects of energy balance.
- definition of equations
for energy balance
- quantitative expression in
terms of equations
- integration of supply and
demand: what are the signals?
- Intrinsic mass action
and feed back processes
- Extrinsic activation,
direct and allosteric
- adequacy of assumptions:
substrate for glycolysis and oxidative phosphorylation adequate oxygen
adequate removal of products, esp. H+
- principles of fitting
techniques: (weighted) least squares, maximum a posteriori
- model adequacy and tests
for model parsimony: how many components and how many parameters?
Guidelines?
- parameter estimates
reliability and confidence testing
Suggested
reading:
- Vicini P, Kushmerick MJ.
Cellular
energetics analysis by a mathematical model of energy balance:
estimation of parameters in human skeletal muscle. Am J Physiol Cell
Physiol. 2000 Jul;279(1):C213-24.
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