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A. Gregory Bruce - Research
Projects Ongoing and Completed Herpesvirus latency and reactivation in
macaque models of human disease, Co-Investigator: A. Gregory Bruce, Ph.D. Agency: Type: R24-RR023343 Period:
07/01/07-06/30/12 The major goals of this project are to complete the sequence of the RFHV genome, develop antibody reagents and serological assays for macaque RV1 and RV2 rhadinoviruses, and analyze the infection and reactivation of the macaque RV1 and RV2 rhadinoviruses in macaques in vivo. “A macaque model for AIDS-related oral malignancies” , Co-Investigator: A. Gregory Bruce, Ph.D. Agency: National Institute of Dental and Craniofacial Research Type: R21 DE016826; Period: (5/1/06-4/30/08) The major goal of this project is to determine the role of the oral cavity in the life cycle and pathogenesis of RFHV in macaques. “CODEHOP: Unique web-based
technology for gene discovery”, Co-Investigator: A. Gregory Bruce,
Ph.D. Agency: Type: R24 RR021346 Period: (9/01/06-8/30/10) The major goal of this project is to further develop the CODEHOP software, web site and PCR amplification technology. Sub-Project: “Primate Pathogen Identification and Characterization”, Co-Investigator: A. Gregory Bruce, Ph.D. Agency: NIH/NCRR; P51 RR00166 (5/01/02-4/30/12) The major goals of this
colony-health related grant are to identify and characterize new primate
pathogens in primate species maintained at the "Cellular Homologs in a
New Simian Gammaherpesvirus", Co-Investigator: A. Gregory Bruce,
Ph.D. Agency: NIH/NCRR; R01 RR13154
(10/01/97-9/30/08) The major goals of this project are to determine the genomic organization of RFHVMn, identify RFHVMn homologs of growth regulatory genes and cytokines, and determine the prevalence of RFHVMn in RF lesions. Sub-Project: "Oncostatin M expression and activity in gingival cells", Co-Investigator: A. Gregory Bruce, Ph.D. P60 Agency: NIH/NCRR; (4/1/99-3/31/02) The major goals of this project are to identify cell types expressing OSM in vivo, study the effects of bacterial pathogens and proinflammatory modulators on the expression of OSM in gingival epithelial cells in vitro, and study the effects of OSM on the expression of various cellular mRNAs as an autocrine factor in gingival epithelial cells and as a paracrine factor in gingival fibroblast cells in vitro. "Expression of Chemokine and Chemokine Receptor Derivatives as Competitors of HIV Infection" Project Director: A. Gregory Bruce, Ph.D. Bristol-Myers Squibb Pharmaceutical Research Institute "Drug Delivery Systems for Growth Factors and Cytokines" Project Director: A. Gregory Bruce, Ph.D. Bristol-Myers Squibb Pharmaceutical Research Institute "Osteoinduction by Transforming Growth Factor Beta" Project Director: A. Gregory Bruce, Ph.D. Bristol-Myers Squibb Pharmaceutical Research Institute |
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