Suggested readings:
·
Chapter
1.1. Evolution: At the Core of Molecular Change and Chapter
1.2. The Molecules of Life - Molecular
and Cell Biology 4th ed., Lodish et al.,ed. 1999
·
Chapter
1 - Bioinformatics and the Internet - Bioinformatics: A Practical Guide to the
Analysis of Genes and Proteins 2nd Edition, Baxevanis AD and Ouellette BF ed.
(2001)
·
The
Molecular Biology Database Collection: an online compilation of relevant
database resources, Galperin, M. (2009), Nucleic Acids Research, Vol.
34, Database issue D1
·
About
the National Center for Biotechnology Information - http://www.ncbi.nih.gov/About/index.html
Suggested readings:
·
Chapter 9- Structure of Genes and Chromosomes
in Molecular
and Cell Biology 4th ed., Lodish et al.,ed. 1999 New York: W H Freeman
& Co
·
Chapter 8.1- Mutations: Types and Causes
in Molecular
and Cell Biology 4th ed., Lodish et al.,ed. 1999 New York: W H Freeman
& Co
Suggested
readings:
Monday
Chapter 11 - Predictive Methods
using Protein Sequences
- (pp 257-258, 269-274) Bioinformatics: A Practical Guide to the Analysis of
Genes and Proteins 2nd Edition, Baxevanis AD and Ouellette BF ed. (2001)
Molecular
and Cell Biology 4th ed., Lodish et al., ed. 1999 New York: W H Freeman
& Co
Chapter 3. Protein Structure and Function,
3.1.
Hierarchical Structure of Proteins ,
Chapter 17. Protein Sorting: Organelle Biogenesis and Protein
Secretion
17.6.
Post-Translational Modifications and Quality Control in the Rough ER
17.7.
Protein Glycosylation in the ER and Golgi Complex
17.8.
Golgi and Post-Golgi Protein Sorting and Proteolytic Processing
Background References (Suggested reading on protein sorting
motifs)
Molecular
and Cell Biology 4th ed., Lodish et al., ed. 1999
Chapter 17. Protein Sorting: Organelle Biogenesis and Protein
Secretion
17
Protein Sorting: Organelle Biogenesis and Protein Secretion,
17.1.
Synthesis and Targeting of Mitochondrial and and Chloroplast Proteins,
17.2.
Synthesis and Targeting of Peroxisomal Proteins,
17.4.
Translocation of Secretory Proteins across the ER Membrane,
17.5.
Insertion of Membrane Proteins into the ER Membrane
Suggested readings:
Background
references:
·
Frequently
Asked Questions (FAQs) concerning BLAST (NCBI)
·
Glossary
of terms used in sequence alignment and BLAST searching
·
Altschul,
S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990).Basic local
alignment search tool. J.Mol.Biol.
215, 403-410.
Suggested readings:
Background
references:
·
Prosite
Database of Protein Families and Domains, Hulo et al., Nucleic Acids
Research, 2006, Vol 34, Database Issue, D227-230
·
Pfam: Clans, Webtools and Services, Finn et al., Nucleic
Acids Research, 2006, Vol. 34, Database issue D247-51
·
Protein family classification based on searching a
database of blocks. Henikoff, S., and Henikoff, J. G.
(1994). Genomics.
19, 97-107.
·
Increased coverage of protein families with the
blocks database servers.
J.G. Henikoff, E.A. Greene, S. Pietrokovski & S. Henikoff, Nucl. Acids Res.
28:228-230 (2000).
·
Blocks+: A non-redundant database of
protein alignment blocks derived from multiple compilations, S. Henikoff, J.G. Henikoff &
S. Pietrokovski, (1999), Bioinformatics
15(6):471-479.
·
Altschul
SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation
of protein database search programs. Nucleic Acids
Res 25, 3389-3402.
Suggested readings:
Background
references:
·
Complementary
DNA sequencing: expressed sequence tags and human genome project. Adams
et al (1991) Science
1991 Jun 21;252(5013):1651-6
Suggested readings:
Suggested readings:
Suggested readings:
Background
references:
Suggested readings:
Revised 3/21/09 (TR)