Review of papers about heart transplantation

Author Date Design yrs N BMD Fxs Markers Comments
Ramsey-Goldman 99 retro 4.5 since tx 61 . 14.7% symptomatic . data from questionnaire
Glendenning 99 xs 2.5 since TX 32 Z-score hip -.79, spine -2.39 7 (22%) vert fx, only 2 sympt. increased, correlated with BMD bxs variable
Boncimino 99 pros 0.25 60 fem -4.3%; spine -4.7% . ocal decreased, no change PTH , deoxypyr inc, 125D dec Mg significantly assoicated with bone loss (inversely!)
Guo 98 xs median 1 since tx 50 z score -.6 spine, -.5 fem . increased BAP, ocal, PTH, decr 125D, test all men, apparently not on vit D Rx
Dopff 98 long 0-2 since tx 57 . . hi PTH, hi CTX&ocalcin .
Shane 97 pros 3 70 1st year spine -7.3%, hip -10.5% . decre test, ocal, incr pyr most loss during 1st year; ocal nadir @1mo, then rose again
Garcia-Delgado 97 RCT 1.5 40 baseline z -.99 to -1.65; 25vitD +4.9%, calcitonin -1.2%, etidronate -.2% 4 in calcitonin, 3 in eti gp PTH no change in any group, ocal up in all gps calcitonin 100u/d; vitD32K/wk, all got Calcium, not blind; BMD showed decrease at 6 mo then increased again
Leidig-Bruckner 97a obs 3.7 105 . 1st year 21%, 2nd 27%, 3rd 33% . .
Shane 97a obs . . . . . some pts lose despite antiresorptive Rx, esp at hip
Sambrook 97a db-bl 2 66 . . . lung or heart; Rx calcitriol or calcium; 8 got hypercalcemia. Calcitriol -2%, calcium -5.8% at hip
Henderson 97a RCT 0.5 41 . . . lung or heart; Rx calcitriol or eti; spine -3.7% in treated groups comp to historical control of -7%. By 12 mo -7%, control -9%.
Shane 97a . . . . . . treatment with eti.
VanCleemput 96 RCT 2 48 eti: spine-10%, hip -7; calcitriol spine -7, hip -5.6 4 symptomatic . eti vs calcitriol; lost bone hip and spine; 2nd year spine gained 1-2%, hip kept losing -3 to 7%
Thiebaue 96 pros 1 48 hip -8.5%, spine - 3.4% . PTH, osteocal up .
Negri 96 xs 3 sinc tx 24 z spine -.9, hip -1.2, similar men&women 29% vert, don't mention sx osteocal up, PTH up more fxs with low fem BMD
Shane 96 pros 1 47 . 36% of pts; most of spine, all but 2 symptomatic . most fx in first 6 months
Rozenberg 95 xs 3 since tx 98 z spine -1.3, hip -.7 men, -1.2 women previous study 5% symptomatic vert . .
Olivari 95 . . . . . . stopped steroids in a group (? if randomized) and they had better BMD than those still on steroids
Sambrook 94 pros 1 25 spine -8.8% . ocal down immediately, then up by one year; Test down, resorption markers up .
Berguer 94 pros 1 47 spine -6%, hip -5.5% in 6 mo, spine more stable next 6 mo . . excluded 5 pts with low BMD who got bisphos
Sambrook 94 . . . . . . same study reported in each journal
Lee 94 xs 2 p tx 31 spine z 0, hip z-.89 8/31 (26%) don't mention sx ocal up, nl test, nl vit D AVN hip in 2 pts
Shane 93 xs 2.5 p tx 40 spine -1.38 women, -.59 men; hip -1.41,-.77 0.35 hi PTH, high osteocalcin .
Meys 98 mixed 2 123 spine z=-.97 by 2 yrs p tx . . pts with low BMD given fluoride which increased BMD
Muchmore 92 pros up to 3 76 QCT dec ~25% 6 mo, then stable x 2 yrs 1/76 followed for over a year . some treated with calcitonin or hormones
Rich 92 xs 3 p tx 16 . 44% of pts clinical . .