| Author | Date | design | yrs | N | BMD | Fxs | Markers | Comments |
| Ramsey-Golman | 99 | retro | 4 since tx | 49 | . | 0.102 | . | data from questionnaire, all symptomatic |
| Vedi | 99 | pros,bx | 0.3 | 21 | . | . | . | increased BFR, MPm 4 to 12%, other changes not sign. |
| Hussaini | 99 | pros | 2 | 56 | dec then inc again | . | . | . |
| Crosbie | 99 | pros | 2 | 12 | only gave T scores (age 48-65) -1.9, dropped to -2.2 then increased again in spine, hip kept losing | . | ocal decred first couple months, then increased. dpy incr | low 25D |
| Reeves | 98 | pros | 0.75 | 13 | . | 0/13 | . | those with spine BMD<.84 given pamidronate Rx pre-tx and post tx |
| Floreani | 98 | pros | 1 | 26 | spine -1.4% at 3 mo, then return to pre tx | . | ocalcin increased after 6 mo, PTH increased progressively | . |
| Ninkovic | 98a | pros | 0.3 | 37 | no change LS, hip .85 to .83 | 35% pre-tx, 27% had new fx, more likely in those with prevalent fx | . | . |
| Leidig-Bruckner | 97a | obs | 3.3 | 130 | . | 1st yr 14%, 2nd 21%, 3rd 31% | . | . |
| Martinez | 97a | xs | 5 p tx | 68 | spine z-1 | . | . | after steroid withdrawal BMD went up to Z=-.4 |
| Giannini | 97a | xs | 1 p tx | 39 | low T scores | . | . | . |
| Eberwein | 97a | pros trial | 2 | 109 | . | 20% with cyclosproine and 12% with FK506 | . | . |
| Monegal | 97 | xs | pre-tx | 58 | low | . | low 25D, low osteocalcin, low test | pts referred for tx |
| Losowsky | 96 | review | . | . | . | . | . | . |
| Riemens | 96 | pros | 1 | 53 | spine -6%;hip -7%, most loss during frst 3 mo at spine, continual at hip | 0.25 | PTH inc,ocal dec | all got 1-alpha and cyclical eti |
| Abdelhaki | 95 | pros | 1 | 9 | decreased p tx | . | ocalcin increased p tx | . |
| Valero | 95 | xs and random, not control | 1 | 120, 40 in trial | spine +6.4% calcitonin, +8.2% eti | . | Ocal high | those with z<-2 random to calcitonin or eti, others lost 3.4%/yr |
| Neuhaus | 95 | obs | 2 | 150 | from 6 mo post tx, LS +5%, hip +2% in untreated, higher in treated | 13% untreated, 0 treated; f/u after first 6 mo | . | treated with various drugs, fluoride, calcitonin |
| Navasa | 94 | xs | . | 91 | . | 0.24 | . | . |
| Hawkins | 94 | xs | 1.5 since tx | 82 | some had OP | no atraumatic fxs | osteocalcin high | . |
| Meys | 94 | pros | 1 | 16 long | 3.5% decrease p tx | 29% (8% in pre-tx group) | . | spine 6 mo -2.7, 12 mo -4.2 |
| Crippin | 94 | retro | . | 203 PBC | low | . | . | those who got estrogen had improvement in BMD without worsening cirrhosis |
| Hay | 93 | review | . | . | . | . | . | . |
| Hodgson | 93 | xs bxs | . | 12 | . | . | . | PBC: dec wall thickness, increase turnover variably, |
| Lindor | 93 | review | . | . | . | . | . | . |
| Rabinovitz | 92 | pros | 0.1 | 30 | . | . | vit D decreased p tx, no change ocalcin after 1 mo | . |
| Arnold | 92 | pros | 1.5 mean | 48 | z score spine -.59 to -.91 | 0.31 | . | convert to % using z = 11%: 3.9, 5.9, 3.5 after 6,12,24 mo |
| Eastell | 91 | xs&obs | . | 210 | PBC 7% lower than age-matched, lost 2%/yr. in 20 pts p tx, decrease at 3 mo, same at 1 yr, 5% above at 2 yr at spine | 13/20 | . | one AVN |
| Hanley | 91 | db-bl | . | 12 | . | . | . | study of cyclosporin in PBC lower PTH, higher osteocalcin |
| McDonald | 91 | pros bxs | 1 | 35 | low; QCT dec 24% in 3 mo, then stable | 1 wrist | . | bone formation lower in men, same in women as in controls pre-tx; 3 got AVN |
| Guanabens | 90 | xs bxs | . | 20 | . | . | . | bxs in pts with PBC show low bone formation, not fullblown OM |
| Watson | 90 | xs | . | 11 | . | . | ocalcin increased with cyclosporin Rx or with tx | all with PBC |