Hyperpara
Author	Date	Comments
Messa	98	81 pts, those with high PTH a year post tx had hx longer time on HD and higher pre-tx PTH levels; some relationship to VDR genotypes seen
D'Alessandro	89	between '81&'87 tx in 1025 pts, 819 survived, 1.8% had PTX mean time 18 mo post tx; 29% had hypercalcemia, of those 25% persisted longer than 7 yrs
Leunissen	86	2 pts with posttransplant high PTH treated with po pamidronate and improved, PTH also fell
Vezzoli	86	xs study of pts 4 yrs post tx found high iCa in 66%
Cundy	83	pros obs of 100 pts for 2 yrs, 36% developed high calcium, mean onset 148 days, assoc with longer time on dialysis and high PTH
Memmos	82	report their series of PTX
McCarron	80	PTH-calcium curves in tx pts show higher baseline but similar shape, suggeting hyperplasia as mechanism
David	73	reviewed 64 pts who had successful renal tx, 34% hypercalcemia, 86% within the first year, persisited in 8 of them, all with high PTH. Also more pre-tx metastatic calcif.
Alfrey	68	17 pts, hypercalcemia in 9, resolved, bone xrays got better
Aluminum
Briner	95	20 pts, Al 48% to 11% 2 yrs post tx
David-Neto	93	11 pts with Al, all improved, necrosis in 6, bxs showed decreased osteoid and al surface, increased bone formation
Davenport	93	38 pts followed prospectively who didnt need transfusions; aluminum decreased and hemoglobin increased; Hb incrase greater in those not given al antacids.
Betolone	93	20 pts aluminum in bone 63 to 36 mcg/kg; bxs decreased osteoid (but none adynamic in the first place)
Dahl	92	Al decreased in bxs pre and post tx in PTX as well as non-PTX pts. Poor reasoning about relation of Al to PTX!
Nordal	92	pros bxs in 55 pts; 10/55 had hypercalcemia; no AVN on standard xrays, cortical thick. decreased, BV same, BFR increased, Al stain decr
Piraino	88	case report - got better post tx
Nordal	88	suggest Al helps rejection, bad statistics
AVN
Lausten	98	xs study 750 pts, AVN 11.2% in high-dose steroids, average 26 mo p tx, and only 5% in low-dose steroids average 20 mo
Holman	95	J Rheumatol from UW - find
Siddiqui	93	some asymptomatic pts with pos MRI resolve; pros study of 72 pts x2yrs, 10 hips nl scan, abn MRI which resolved in 6, no sx; 13 scan abn, MRI nl, resolved in 8; 3 pts had sx and both studies pos
Fordyce	93	32 pts, 3 had pos MRI but no sx, one later got sx
Churchill	91	29 pts with stage 3 or 4 AVN, mean onset of sx 33 mo post tx, by 3 yrs 60% of hips needed surgery, by 5 yrs 80%
Kopecky	91	104 pts, pros x 24 mo, 10 developed MRI pos, 4 of them developed pain. Xrays pos in the 4 with sx.
Patton	88	444 pts, 16% got AVN sx, related to steroid dose
Landmann	87	AVN in 15/174 pre cyclosporin, 1/96 post
Spencer	83	bone scans showed AVN in 8/42 pts, 7 became symptomatic
Nixon	79	AVN in 14 of 181 within 4 yrs.
Ibels	78	40/184, 21% had symptomatic AVN, 15 of them had surgery
Amyloid
Tan	96	KI article - find
Barden	95	14 pts tx after ?10 yrs HD, articular sx better in 10, still had amyloid deposits and subchondral bone erosions
Jadoul	89	amyloid pain improved post tx, maybe due to steroids, no new cysts for 4 yrs but no regression either