Conj 532 - Signal Transduction:
From the cell membrane to the nucleus
Announcements Schedule Faculty and TAs Grading Policies Grades |
Announcements: 2012 Class starts on Wednesday, Oct 29 at 12:30 PM, in Room T-739
Welcome to the Course web page for Conj532 - Signal Transduction: From the cell membrane to the nucleus - Fall Quarter 2012
Course Administration: The course will be administrated by Drs. Joe Beavo (F404), Dan Storm (J681F) and staff in the Department of Pharmacology in the Health Sciences Bldg. Any comments or questions about the course can be directed to Drs. Beavo or Storm. Instructors also include Dr John Scott, and Dr Randy Moon.
Lectures: 12:30 - 1:20 P.M., Room T-747
Monday, Wednesday, and Friday, Oct 29 - Dec 13, 2012
FINAL EXAM: December 13th at 8:30 AM, T-739
See the online.
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After accessing this web site, please follow the instructions given by the instructor.
The assignments below are for the 2012 course offering.
They are given in reverse order of presentation for your ease of retrieval.
Beavo/Atkins - MedChem/Phcol Joint Class April 2, 2013
BeavoAtkins - cG Mechanism Papers
BeavoAtkins - cG PK Papers
Moon - Lecture 15, December 5, 2012, 2012
Moon - Lecture 15 as keynote
Moon - Lecture 15 as ppt
Moon - Lecture 15 as pdf
Scott - Lecture 14, December 3, 2012
Scott - Lecture 14 notes
Scott - Article 1
Scott - Article 2
Scott - Article 3
Moon - Lecture 13, November 30, 2012
Moon - Moon Take Home Question
Moon - Lecture 13 as keynote
Moon - Lecture 13 as ppt
Moon - Lecture 13 as pdf
Moon - Lecture 12, November 28, 2012
Please take a look at the two posted papers.
Moon - Lecture 12 as keynote
Moon - Lecture 12 as ppt
Moon - Lecture 12 as pdf
Moon - Article 1 - Cell Review
Moon - Article 2 - Structure Review
Beavo - Lecture 11, November 26, 2012
Please look at the short review, and the recent research paper on the same topic.
Beavo - Lecture 11 Notes
Beavo - Article 1
Beavo - Article 2
Storm - Lecture 10, November 21, 2012
Storm - Lecture 10 Slides
Storm - Lecture 10 Notes
Storm - Article 1
Storm - Question
Storm - Question Due November 26th in class, please do not email.
Storm - Lecture 8 and 9, November 16 and 19, 2012
Storm - Lecture 8 and 9 Slides
Storm - Lecture and 9 Notes
Storm - Article 1
Storm - Lecture 7, November 14, 2012
Storm - Lecture 7 Slides
Storm - Lecture 7 Notes
Storm - Article 1
Storm - Article 2
Beavo - Lecture 6, November 9, 2012
There is a short review, and one research paper. You may answer a question regarding these papers in place of the one distributed with the last lecture if you wish. Also due Nov 14.
Beavo - Lecture 6 Notes
Beavo - Article 1 - A short review
Beavo - Article 2
Beavo - Article 3 - Short Review of Insulin and Glucose Transport
Beavo - Lecture 5, November 7, 2012
There is a short review, two research papers, and a paper that gives a slightly alternate view here. Please have a look in enough detail to understand the current controversy.
Beavo - Lecture 5 Notes
Beavo - Article 1 - A short review
Beavo - Article 2
Beavo - Article 3
Scott - Lecture 4, November 5, 2012
Scott - Lecture 4 Notes
Scott - Article 1
Scott - Article 2
Scott - Article 3
Scott - Lecture 3, November 2, 2012
Scott - Lecture 3 Notes
Scott - Article 1
Scott - Article 2
Scott - Article 3
Scott - Article 4
Scott - Lecture 2, October 31, 2012
Scott - Lecture 2 Notes
Scott - Article 1
Scott - Article 2
Scott - Lecture 1, October 29, 2012
Scott - Lecture 1 Notes
Scott - Article 1
Scott - Article 2
QUESTION 1
Scott - Articles for Question 1
Navedo et al. 2010
Hoshi et al. 2010
Gold et al. 2011
Hinke et al. 2011
Please note, your grade will be 50% determined by a final exam and 50% determined by answers to a weekly question you will be asked to submit. These questions will be based partly on lecture material and partly on papers that you will be asked to read. It is OK to discuss ideas about questions with your classmates; however, we want you to write your own answers ultimately using your own ideas and words. Direct plagiarism is highly discouraged. Each answer is worth 25 points. There likely will be 4 questions total during this mini quarter. As mentioned, the answers to these questions will count for 50% of your grade so take them seriously. Zeros for even a single question do not average well for your grade :-) ! However, concise answers are encouraged and those longer than 1 page may be given a lower score.
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Textbooks:
There will be no required textbook for the course although you may find Cooper's "The Cell" or Lodish's "Molecular Cell Biology" or Pollard's "Cell Biology" helpful if you do not have a good background in signal transduction. We expect the students to have a basic understanding of biochemistry and cell biology as one would get in a typical 400 level undergraduate course on the subject. Each week a series of several research papers and/or reviews will be assigned. Students are expected to read these manuscripts BEFORE class.
Handouts:
Handouts containing abbreviated versions of parts of the material to be covered will be given out for most lectures and be available on the Web site. Often these will contain outline copies of the slides used in lecture particularly if they are not included in the assigned reading papers. Where possible, pdf reprints of relevant papers will also be provided at the course Web site ( http://courses.washington.edu/conj532/ ).
Discussion sessions:
Every few lectures the instructor will include as part of their lecture a discussion of a new and/or somewhat controversial series of papers in the area being covered. The students will be given the papers during the week before the lecture and also a series of questions related to them. They will be expected to hand in answers to these study questions at the BEGINNING of the discussion lecture. The answers are to be typed and no longer than 1 page (double spaced, 12 pt font, 0.7 inch margins). These written answers will be used as the basis for 50% of the final grade in the course. Part of the class time will be devoted to discussion of possible answers to the questions. Note, often times more than one correct answer is possible.
Exams:
There will be one major exam, the final. This exam will be in the form of short answer essay questions. The exam this year likely will be held Dec 13 at 8:30 AM (right now scheduled for T-739) during the finals week. Because of the essay format, it is unlikely that final grades will be available immediately. This exam time may change so keep tuned!
Grades:
Grades will be based on the cumulative results of the discussion questions and on the final exam. The final will count for 50% of the grade and the cumulative written analysis for 50%.
Faculty:
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