Conj 532 - Signal Transduction:
From the cell membrane to the nucleus
Announcements Schedule Faculty and TAs Grading Policies Grades |
Announcements: 2011 Class starts on Wednesday, Nov 2 at 12:30 PM, in Room T-747
Welcome to the Course web page for Conj 532 - Signal Transduction (2011): From the cell membrane to the nucleus - Fall Quarter 2011
Course Administration: The course will be administrated by Drs. Joe Beavo (F404), Dan Storm (J681F) and staff in the Department of Pharmacology in the Health Sciences Bldg. Any comments or questions about the course can be directed to Drs. Beavo or Storm. Instructors also include Dr John Scott, and Dr Randy Moon.
Lectures: 12:30 - 1:20 P.M., Room T-747
Monday, Wednesday, and Friday, Nov 2 - Dec 12, 2011
FINAL EXAM: Now moved up to December 12th at 12:30 PM , T-747, (Good news, we finally got this earlier date as many of you requested).
See the schedule for more details.
Look up your grade (active after 1st homework assignment) online.
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After accessing this web site, please follow the instructions given by the instructor.
The assignments below are for the 2011 course offering.
They are given in reverse order of presentation for your ease of retrieval.
Your reading assignments will be posted a day or two before the lectures.
Scott - Lecture 15, December 9, 2011
Scott - Heck Paper
Scott - Robinson Paper
Scott - Baumeister Paper
Scott - Scott Lecture Notes
Note, handouts for these 3 lectures by Dr Moon will NOT be provided. You may want to download the PDF slides ahead of time or just take notes during the lecture.
Moon - Lecture 14, December 7, 2011
Moon - Moon Lecture 3 Slides
Moon - Lecture 13, December 5, 2011
Moon - Moon Lecture 2 Slides
Moon - Moon Take Home Question (Due Dec 12 at final exam)
Moon - Lecture 12, December 2, 2011
Moon - Nusse Review Paper
Moon - RNAi TakeHome Background Paper
Moon - Moon Lecture 1 Slides
Storm - Lecture 11, November 30, 2011
Storm - Savic Paper
Storm - Wang Paper
Storm - Phermones_Lecture Slides
Storm - Storm Olfaction Notes
Storm - Lecture 10, November 28, 2011
Storm - Mahan Paper
Storm - Shan Paper
Storm - Memory2_Lecture Slides
Storm - Storm Take Home Question (Due Dec 2)
Storm - Lecture 9, November 23, 2011
Storm - Wang Paper
Storm - Sindreu Paper
Storm - Memory_Lecture Notes
Storm - Memory_Lecture Slides
Storm - Lecture 8, November 21, 2011
Storm - Stork Review
Storm - Lecture Notes
Storm - MAPK1_Lecture Slides
Beavo - Lecture 7, November 18, 2011
Beavo - Mohr Review
Beavo - Richard Review
Beavo - Inflamasome Review
Beavo - Cytokine_Lecture Slides
Beavo - Lecture 6, November 16, 2011
Beavo - Kalupahana Review
Beavo - Gao Article
Beavo - White Review*
Beavo - Insulin_Lecture Slides
Beavo - Lecture 5, November 14, 2011
Beavo - Kass Review
Beavo - Lukowski Article
Beavo - Zhang Article
Beavo - Beavo Weekly Question (Due Monday Nov 21)
Beavo - NO_Lecture Slides
Scott - Lecture 4, November 9, 2011
Scott - Article 4-1
Scott - Article 4-2
Scott - Article 4-3
Scott - Article 4-4
Scott - Article 4-5
Scott - Lecture 4 Notes
Scott - Lecture 3, November 7, 2011
Scott - Article 3-1
Scott - Article 3-2
Scott - Article 3-3
Scott - Lecture 3 Notes
Scott - Lecture 2, November 4, 2011
Scott - Lecture 2 Notes
Scott - Article 1
Scott - Article 2
The following articles/pages may be helpful to you in answering this weeks question.
Scott - Article 3
Scott - Article 4
Scott - Article 5
Scott - Article 6
Scott - Article 7
Beavo - Lecture 1, November 2, 2011 (please read at least one of reviews below)
Beavo - PDF Lecture 1 Notes
Beavo - Luttrell Review Article, a rather comprehensive review of a "new" mechanism of 7TM signaling
Beavo - Lefkowitz Review, a shorter but more pharmacologically focused very recent review by leader in field
Please note, your grade will be 50% determined by a final exam and 50% determined by answers to a weekly question you will be asked to submit. These questions will be based partly on lecture material and partly on papers that you will be asked to read. It is OK to discuss ideas about questions with your classmates; however, we want you to write your own answers ultimately using your own ideas and words. Direct plagarism is highly discouraged. Each answer is worth 25 points. There likely will be 4 questions total during this mini quarter. As mentioned, the answers to these questions will count for 50% of your grade so take them seriously. Zeros for eve a single question do not average well! However, concise answers are encouraged and those longer than 1 page may be given a lower score.
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Textbooks:
There will be no required textbook for the course although you may find Cooper's "The Cell" or Lodish's "Molecular Cell Biology" or Pollard's "Cell Biology" helpful if you do not have a good background in signal transduction. We expect the students to have a basic understanding of biochemistry and cell biology as one would get in a typical 400 level undergraduate course on the subject. Each week a series of several research papers and/or reviews will be assigned. Students are expected to read these manuscripts BEFORE class.
Handouts:
Handouts containing abbreviated versions of parts of the material to be covered will be given out for most lectures and be available on the Web site. Often these will contain outline copies of the slides used in lecture particularly if they are not included in the assigned reading papers. Where possible, pdf reprints of relevant papers will also be provided at the course Web site ( http://courses.washington.edu/conj532/ ).
Discussion sessions:
Every few lectures the instructor will include as part of their lecture a discussion of a new and/or somewhat controversial series of papers in the area being covered. The students will be given the papers during the week before the lecture and also a series of questions related to them. They will be expected to hand in answers to these study questions at the BEGINNING of the discussion lecture. The answers are to be typed and no longer than 1 page (double spaced, 12 pt font, 0.7 inch margins). These written answers will be used as the basis for 50% of the final grade in the course. Part of the class time will be devoted to discussion of possible answers to the questions. Note, often times more than one correct answer is possible.
Exams:
There will be one major exam, the final. This exam will be in the form of short answer essay questions. The exam this year be held Dec 12 at 12:30 PM (right now scheduled for T-747) during the finals week. Because of the essay format, it is unlikely that final grades will be available immediately. This exam time may change so keep tuned!
Grades:
Grades will be based on the cumulative results of the discussion questions and on the final exam. The final will count for 50% of the grade and the cumulative written analysis for 50%.
Faculty:
Dr. Joe Beavo - F404A, 543-4006 beavo@uw.edu
Dr. Daniel Storm - J681F, 543-7028 dstorm@uw.edu
Dr. Randall T. Moon - 815 Mercer St, S524, 543-1722 rtmoon@uw.edu
Dr. John Scott - K-336B, 616-3340 scottjdw@uw.edu
Secretary: Pat Lew - F406
Links:
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