Uconj 532 - Signal Transduction:
From the cell membrane to the nucleus


Announcements

Schedule

Faculty and TAs

Grading Policies

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Announcements: Class starts on Mon, Oct 29 at 12:30 PM, in Room S-060, Foege Auditorium

Welcome to the Course web page for Uconj 532 - Signal Transduction (2007): From the cell membrane to the nucleus  -  Fall Quarter 2007

Course Administration: The course will be administrated by Drs. Joe Beavo (F404), Dan Storm (J681F) and staff in the Department of Pharmacology in the Health Sciences Bldg. Any comments or questions about the course can be directed to Drs. Beavo or Storm.

Lectures: 12:30 - 1:20 P.M., Room S-060, Foege Auditorium
Monday, Wednesday, and Friday, Oct 29 - Dec 5, 2007

FINAL EXAM Monday Dec 10 at 12:30 PM, S-060, 2 hours available


Week of Dec 3, 2007 - Moon - Monday Lecture by Travis Biechele and Ben Major Nature siRNA Movie Link
http://www.nature.com/focus/rnai/animations/index.html


  • Moon - Ben's Slides (pdf)
  • Moon - Travis' Slides (pdf)

    Week of Nov 26, 2007 - Storm - Please read the first 3 papers BEFORE class on 26th

  • Storm - NFkBReview (pdf)
  • Storm - Cude Paper (pdf)
  • Storm - LubinSweatt Paper (pdf)
  • Storm - Shinmzu Paper (pdf)
  • Storm - Sindreu Paper (pdf)
  • Storm - Storm NFKB slides (pdf)
  • Storm - Storm NFKB Notes (pdf)
  • Storm - Storm NFKB Notes (pdf)
  • Storm - Storm NFKB Notes (pdf)
  • Storm - Storm NFKB Notes (doc)
  • Storm - Storm Memory Slides (pdf)
  • Storm - Buck Paper (pdf)
  • Storm - Storm Olfaction Notes (doc)
  • Storm - Storm Olfaction Slides (pdf)

    Week of Nov 19, 2007 - Beavo, NO_cGMP & Rapid Signaling:

  • Beavo - Takemoto Cirs Res 05 (pdf)
  • Beavo - Slides from NO cGMP lecture (pdf)
  • Beavo - cGKReview - Transgenic Animals (pdf)
  • Beavo - Rapid Signaling Slides (pdf)
  • Beavo - ZaccoloCircRes06 (pdf)
  • Beavo - LohseFRETRev07 (pdf)
  • Beavo - BRETRev07 (pdf)
  • Week of Nov 12, 2007 - Beavo, Insulin & Cytokines:

  • Beavo - Morris White Review (shorter of 2 reviews) (pdf)
  • Beavo - Biddinger Kahn Review (longer but better) (pdf)
  • Beavo - Pessin Paper (pdf)
  • Beavo - Insulin Slides (pdf)
  • Beavo - JAK_STAT Minireview (pdf)
  • Beavo - Flier SOCS Paper (pdf)
  • Beavo - Cytokine Slides (pdf)
  • Beavo - BeavoTakeHomeQ3 (doc, Due Nov 28)
  • Week of Nov 5, 2007 - Moon, Beavo:

  • Moon - Lecture 2 (pdf)
  • Moon - Lecture 2 (ppt)
  • Moon - Hedgehog Review
  • Moon - Question - (Due Dec 5)
  • Beavo - Reading Assignment - Article 1
  • Beavo - Reading Assignment - Article 2
  • Beavo - Reading Assignment - Article 3 - Recent Holz Review
  • Beavo - Lecture 11/7/07 - Slides
  • Beavo - Lecture 11/9/07 - Slides
  • Beavo - Question 1 - (Due Nov 14)
  • Week of Oct 29, 2007 - Storm, Beavo, Moon:

  • Storm - Article 1 - Calmodulin
  • Storm - Article 2 - Acyclases
  • Storm - Article 3 - G protein Disease
  • Storm - Article 4 - General Review
  • Storm - Lecture 1 - Slides
  • Storm - Question 1 - Due Fridays
  • AKAP Rev05
  • AKAP Rev07
  • Moon - Lecture 1a (pdf)
  • Moon - Lecture 1a (ppt)
  • Moon - Lecture 1b
  • Moon - Interavtive Movie
  • Question 1 will be posted shortly and due Monday Nov 5, Note it is OK to discuss ideas about answers with your classmates; however, we want you to write your own answers ultimately using your own ideas and words. Direct plagarism is highly discouraged. Each answer is worth 25 points. There likely will be 4 questions total during this mini quarter. The answers to these questions will count for 50% of your grade so take them seriously. However, answers longer than 1 page may be given a lower score. ------------------------

    Textbooks:

    Textbooks: There will be no required textbook for the course although you may find Cooper's "The Cell" or Lodish's "Molecular Cell Biology" or Pollard's "Cell Biology" helpful if you do not have a good background in signal transduction. We expect the students to have a basic understanding of biochemistry and cell biology as one would get in a typical 400 level undergraduate course on the subject. Each week a series of several research papers and/or reviews will be assigned. Students are expected to read these manuscripts BEFORE class.

    Handouts:

    Handouts: Handouts containing abbreviated versions of parts of the material to be covered will be given out for most lectures and be available on the Web site. Often these will contain outline copies of the slides used in lecture particularly if they are not included in the assigned reading papers. Where possible, pdf reprints of relevant papers will also be provided at the course Web site ( http://courses.washington.edu/conj532/ ).

    Discussion sessions:

    Discussion sessions: Every few lectures the instructor will include as part of their lecture a discussion of a new and/or somewhat controversial series of papers in the area being covered. The students will be given the papers during the week before the lecture and also a series of questions related to them.  They will be expected to hand in answers to these study questions at the BEGINNING of the discussion lecture. The answers are to be typed and no longer than 1 page (double spaced, 12 pt font, 0.7 inch margins). These written answers will be used as the basis for 50% of the final grade in the course. Part of the class time will be devoted to discussion of possible answers to the questions. Note, often times more than one correct answer is possible.

    Exams: Exams: There will be one major exam, the final. This exam will be in the form of short answer essay questions. The exam will be held MONDAY Dec 10 at 12:30M in our normal classroom. Because of the essay format, it is unlikely that final grades will be available immediately. This exam time may change so keep tuned!

    Grades: Grades will be based on the cumulative results of the discussion questions and on the final exam. The final will count for 50% of the grade and the cumulative written analysis for 50%.

    Faculty:

    Dr. Joe Beavo F404A, 543-4006 beavo@u.washington.edu

    Dr. Daniel Storm - J681F, 543-7028 dstorm@u.washington.edu

    Dr. Randall T. Moon - K-356C, 543-1722 - rtmoon@u.washington.edu

    Secretary:  Pat Kong F406


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