Conj 532 – Signal Transduction: From the cell membrane to the nucleus

Room: Foege S060 - MWF 12:30 -1:20 PM  - Mon Oct 29 - Dec 10, 2007

 

#

Day

Date

Tentative Schedule of Lecture Topics

Lecturer

 

1

M

Oct 29

Introduction to 2 messenger signal transduction systems -

  - The cAMP signal transduction system

 

D. Storm

 

2

W

Oct 31

General principles of G protein coupling

 

J. Beavo

 

3

F

Nov 2

Proteolysis and signal transduction:

WNT –1 signaling

R Moon

 

4

M

Nov 5

Proteolysis and signal transduction:

Hedgehog and Notch signaling pathways.

R Moon

5

W

Nov 7

Introduction to tyrosine receptor kinase cascades:

  - Map kinase cascades

J. Beavo

 

6

F

Nov 9

Tyrosine Receptor Kinase pathways (continued)

   GEFs & GAFs and cAMP

J. Beavo

 

 

M

Nov 12

Veterans Day Holiday

 

 

7

W

Nov 14

Insulin, IGF-1, IRS signaling

 

J. Beavo

 

8

F

Nov 16

Introduction to Cytokine/Jak/Stat signaling pathways

J. Beavo

 

9

M

Nov 19

Cytokine/Jak/Stat signaling pathways (continued)

Intro to Nitric Oxide signaling

J Beavo

 

10

W

Nov 21

Nitric oxide/CO/cGMP signaling pathways (continued)

  -  Mechanism of action of Viagra

Turning off the signals

J. Beavo

 

 

 

F

Nov 23

Holiday - Thanksgiving Break

 

11

M

Nov 26

Introduction to NfKb pathway

D. Storm

 

12

W

Nov 28

The Molecular Basis of Memory Formation

 

D. Storm

13

F

Nov 30

 

The Molecular Basis of Chemosensation

D. Storm

14

M

Dec 3

A Current Approach for Dissecting Signaling Pathways

R Moon

 

15

W

Dec 5

Signaling pathways in developmental biology

 

R. Moon

 

F

Dec 7

No Class

 

 

 

Mon

Dec 10

In Class Final Exam – 12:30 PM S060 Foege Auditorium.

 

 


Course Administration: The course will be administrated by Drs. Joe Beavo (F406), Dan Storm (J681F) and staff in the Department of Pharmacology in the Health Sciences Bldg.  Any comments or questions about the course can be directed to Drs. Beavo or Storm.

 

Textbooks: There will be no required textbook for the course although you may find Cooper's "The Cell" or Lodish's "Molecular Cell Biology" or Pollard's "Cell Biology" helpful if you do not have a good background in signal transduction.  We expect the students to have a basic understanding of biochemistry and cell biology as one would get in a typical 400 level undergraduate course on the subject.  Each week a series of several research papers and/or reviews will be assigned.  Students are expected to read these manuscripts BEFORE class.

 

Handouts:  Handouts containing abbreviated versions of parts of the material to be covered will be given out for most lectures and be available on the Web site.  Often these will contain outline copies of most of the more complex figures used in lecture particularly if they are not included in the assigned reading papers.  Where possible, pdf reprints of relevant papers will also be provided at the course Web site  (http://courses.washington.edu/conj532/).

 

Discussion sessions: Every few lectures the instructor will include as part of their lecture a discussion of a new and/or somewhat controversial series of papers in the area being covered.  The students will be given the papers in the week before the lecture and also a series of questions related to them.  They will be expected to hand in answers to these study questions at the BEGINNING of the discussion lecture.  The answers are to be typed and no longer than 1 page (double spaced, 12 pt font, 0.7 inch margins).  These written answers will be used as the basis for 50% of the final grade in the course.  Part of the class time will be devoted to discussion of possible answers to the questions.  Note, often times more than one correct answer is possible. 

 

Exams:  There will be one major exam, the final.  This exam will be in the form of short answer essay questions.  Because of the essay format, it is unlikely that final grades will be available immediately but will be posted on the web as soon as possible.

 

Grades:  Grades will be based on the cumulative results of the discussion questions and on the final exam.  The final will count for 50% of the grade and the cumulative written analysis for 50%.

 

Faculty:

 

Dr. Joe Beavo                            Dr. Daniel Storm                       Dr. Randall T. Moon

F404A, 543-4006                     J681F, 543-7028                       K-536C, 543-1722

beavo@u.washington.edu      dstorm@u.washington.edu     rtmoon@u.washington.edu