Room: Foege S060 - MWF
12:30 -1:20 PM - Mon Oct 29 - Dec
10, 2007
|
# |
Day |
Date |
Tentative Schedule of Lecture Topics |
Lecturer |
|
1 |
M |
Oct 29 |
Introduction to 2 messenger
signal transduction systems - - The
cAMP signal transduction system |
D. Storm |
|
2 |
W |
Oct 31 |
General principles of G protein coupling |
J. Beavo |
|
3 |
F |
Nov 2 |
Proteolysis and signal
transduction: WNT –1 signaling |
R Moon |
|
4 |
M |
Nov 5 |
Proteolysis and signal
transduction: Hedgehog and Notch
signaling pathways. |
R Moon |
|
5 |
W |
Nov 7 |
Introduction to tyrosine receptor kinase cascades: - Map
kinase cascades |
J. Beavo |
|
6 |
F |
Nov 9 |
Tyrosine Receptor Kinase pathways (continued) GEFs & GAFs and cAMP |
J. Beavo |
|
|
M |
Nov 12 |
Veterans Day Holiday |
|
|
7 |
W |
Nov 14 |
Insulin, IGF-1, IRS
signaling |
J. Beavo |
|
8 |
F |
Nov 16 |
Introduction to Cytokine/Jak/Stat
signaling pathways |
J. Beavo |
|
9 |
M |
Nov 19 |
Cytokine/Jak/Stat signaling pathways (continued) Intro to Nitric Oxide signaling |
J Beavo |
|
10 |
W |
Nov 21 |
Nitric oxide/CO/cGMP signaling pathways (continued) - Mechanism of action of Viagra Turning off the signals |
J. Beavo |
|
|
F |
Nov 23 |
Holiday - Thanksgiving Break |
|
|
11 |
M |
Nov 26 |
Introduction to NfKb pathway |
D. Storm |
|
12 |
W |
Nov 28 |
The Molecular
Basis of Memory Formation |
D. Storm |
|
13 |
F |
Nov 30 |
The Molecular Basis of Chemosensation |
D. Storm |
|
14 |
M |
Dec 3 |
A Current Approach for Dissecting Signaling Pathways |
R Moon |
|
15 |
W |
Dec 5 |
Signaling pathways in
developmental biology |
R. Moon |
|
|
F |
Dec 7 |
No Class |
|
|
|
Mon |
Dec 10 |
In Class Final Exam – 12:30 PM S060 Foege
Auditorium. |
|
Course Administration: The course will be administrated by Drs. Joe Beavo
(F406), Dan Storm (J681F) and staff in the Department of Pharmacology in the
Health Sciences Bldg. Any comments
or questions about the course can be directed to Drs. Beavo or Storm.
Textbooks: There will be no required textbook for the course although
you may find Cooper's "The Cell" or Lodish's "Molecular Cell
Biology" or Pollard's "Cell Biology" helpful if you do not have
a good background in signal transduction.
We expect the students to have a basic understanding of biochemistry and
cell biology as one would get in a typical 400 level undergraduate course on
the subject. Each week a series of
several research papers and/or reviews will be assigned. Students are expected to read these
manuscripts BEFORE class.
Handouts: Handouts
containing abbreviated versions of parts of the material to be covered will be
given out for most lectures and be available on the Web site. Often these will contain outline copies
of most of the more complex figures used in lecture particularly if they are
not included in the assigned reading papers. Where possible, pdf reprints of relevant papers will also be
provided at the course Web site (http://courses.washington.edu/conj532/).
Discussion sessions: Every few lectures the instructor will include as
part of their lecture a discussion of a new and/or somewhat controversial
series of papers in the area being covered. The students will be given the papers in the week before the
lecture and also a series of questions related to them. They will be expected to hand in
answers to these study questions at the BEGINNING of the discussion
lecture. The answers are to be
typed and no longer than 1 page (double spaced, 12 pt font, 0.7 inch
margins). These written answers
will be used as the basis for 50% of the final grade in the course. Part of the class time will be devoted
to discussion of possible answers to the questions. Note, often times more than one correct answer is
possible.
Exams: There will be
one major exam, the final. This
exam will be in the form of short answer essay questions. Because of the essay format, it is
unlikely that final grades will be available immediately but will be posted on
the web as soon as possible.
Grades: Grades will be
based on the cumulative results of the discussion questions and on the final
exam. The final will count for 50%
of the grade and the cumulative written analysis for 50%.
Faculty:
Dr. Joe Beavo Dr.
Daniel Storm Dr. Randall T. Moon
F404A, 543-4006 J681F,
543-7028 K-536C, 543-1722
beavo@u.washington.edu dstorm@u.washington.edu rtmoon@u.washington.edu