T747 - MWF - 12:30 PM
– 1:30 PM - Nov 2 - Dec 9, 2011
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Lecture # |
Day |
Date |
Tentative Schedule of Lecture Topics |
Lecturer
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1 |
W |
Nov 2 |
Introduction to course |
J. Beavo |
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2 |
F |
Nov 4 |
Basic elements of signal
transduction systems - |
J Scott |
|
3 |
M |
Nov 7 |
Protein-protein coupling and G protein coupling |
J Scott |
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4 |
W |
Nov 9 |
cAMP pathway and compartmentalized signaling |
J Scott |
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|
F |
Nov 11 |
Veterans Day Holiday – Nov 11
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|
5 |
M |
Nov 14 |
Nitric oxide/CO/cGMP
signaling pathways |
J. Beavo |
|
6 |
W |
Nov 16 |
Insulin, IGF-1, IRS signaling |
J Beavo |
|
7 |
F |
Nov 18 |
Introduction to Cytokine/Jak/Stat signaling pathways |
J. Beavo |
|
8 |
M |
Nov 21 |
Cross talk between cAMP and MAPK signaling |
D. Storm |
|
9 |
W |
Nov 23 |
Molecular and Cellular
Basis of Memory Formation I |
D. Storm |
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|
F |
Nov 25 |
Thanksgiving
Break - Nov 24-25 |
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|
10 |
M |
Nov 28 |
Molecular and Cellular
Basis of Memory Formation II |
D. Storm |
|
11 |
W |
Nov 30 |
Chemosensory mechanisms |
D. Storm |
|
12 |
F |
Dec 2 |
Proteolysis and signal
transduction: Hedgehog
and Notch signaling pathways |
R Moon |
|
13 |
M |
Dec 5 |
Proteolysis and signal
transduction:
WNT –1 signaling |
R Moon |
|
14 |
W |
Dec 7 |
Signaling pathways in
developmental biology |
R. Moon |
|
15 |
F |
Dec 9 |
Macromolecular signaling
assemblies |
J. Scott |
|
|
W? |
Dec 14? |
In Class
Final Exam – Scheduled to be Dec 12 @ 12:30 PM This should be firm now as
of Nov 2. |
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Course Administration: The course will
be administrated by Drs. Joe Beavo (F404), Dan Storm (J681F) and staff in the
Department of Pharmacology in the Health Sciences Bldg. Any comments or questions about the
course can be directed to Drs. Beavo or Storm. There will also be lectures by
Drs. John Scott and Randy Moon.
Textbooks: There will be no required textbook for the course
although you may find any recent Molecular Cell Biology or Cell Biology text helpful if
you do not have a good background in signal transduction. We expect the students to have a basic
understanding of biochemistry and cell biology as one would get in a typical
400 level undergraduate course on the subject. Each week a series of several research
papers and/or reviews will be assigned.
Students are expected to read these manuscripts BEFORE class.
Handouts: Handouts
containing abbreviated versions of parts of the material to be covered will be
given out for most lectures and be available on the Web site. Often these will contain outline copies
of most of the more complex figures used in lecture particularly if they are
not included in the assigned reading papers. Where possible, pdf
reprints of relevant papers will also be provided at the course Web site (http://courses.washington.edu/conj532/).
Discussion sessions: Every few lectures the instructor will include as
part of their lecture a discussion of a new and/or somewhat controversial
series of papers in the area being covered. The students will be given the papers in
the week before the lecture and also a series of questions related to
them. They will be expected to hand
in answers to these study questions at the BEGINNING of the discussion
lecture. The answers are to be typed
and no longer than 1 page (double spaced, 12 pt font, 0.7 inch margins). These written answers will be used as
the basis for 50% of the final grade in the course. When possible part of the class time
will be devoted to discussion of possible answers to the questions. Note, often times more than one correct
answer is possible.
Exams: There will be
one major exam, the final. This
exam will be in the form of short answer essay questions. The exam will be held in the lecture
hall during the finals week.
Because of the essay format, it is unlikely that final grades will be
available immediately but will be posted on the web as soon as possible.
Grades: Grades will be
based on the cumulative results of the discussion questions and on the final
exam. The final will count for 50%
of the grade and the cumulative written analysis for 50%.
Faculty:
Dr. Joe Beavo Dr.
Daniel Storm
F404A, 543-4006 J681F,
543-7028
beavo@u.washington.edu dstorm@u.washington.edu
Dr. Randall T. Moon Dr.
John Scott
SLU Campus, Rm S524 HSB
K-336B
206- 543-1722 206-616-3340
rtmoon@u.washington.edu
scottjdw@u.washington.edu