Conjoint 538, Genetic Instability and Cancer

 

Useful Review Articles

 

Repair and Genetics of Cancer

Demant, P. (2003). Cancer susceptibility in the mouse: genetics, biology and implications for human cancer. Nat Rev Genet 4, 721-734.

Hussain, S. P., Hofseth, L. J., and Harris, C. C. (2003). Radical causes of cancer. Nat Rev Cancer 3, 276-285.

Heyer, J., Yang, K., Lipkin, M., Edelmann, W., and Kucherlapati, R. (1999). Mouse models for colorectal cancer. Oncogene 18, 5325-5333.

Hoeijmakers, J. H. (2001). Genome maintenance mechanisms for preventing cancer. Nature 411.

Mitchell, J. R., Hoeijmakers, J. H., and Niedernhofer, L. J. (2003). Divide and conquer: nucleotide excision repair battles cancer and ageing. Curr Opin Cell Biol 15, 232-240.

Wood, R. D., Mitchell, M., Sgouros, J., and Lindahl, T. (2001). Human DNA repair genes. Science 291, 1284-1289.

 

Repair Genes and Pathways

D'Andrea, A. D., and Grompe, M. (2003). The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 3, 23-34.

Kolodner, R. D., Putnam, C. D., and Myung, K. (2002). Maintenance of genome stability in Saccharomyces cerevisiae. Science 297, 552-557.

 

DNA Damage Repair

Riedl, T., Hanaoka, F., and Egly, J. M. (2003). The comings and goings of nucleotide excision repair factors on damaged DNA. Embo J 22, 5293-5303.

Mills, K. D., Ferguson, D. O., and Alt, F. W. (2003). The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev 194, 77-95.

Sarasin, A. (2003). An overview of the mechanisms of mutagenesis and carcinogenesis. Mutat Res 544, 99-106.

 

Mismatch repair

Schofield, M. J., and Hsieh, P. (2003). DNA mismatch repair: molecular mechanisms and biological function. Annu Rev Microbiol 57, 579-608 (not on the web yet, as of 1/5/04).

 

Repair, Replication and Polymerases

Goodman, M. F. (2002). Error-prone repair DNA polymerases in prokaryotes and eukaryotes. Annu Rev Biochem 71, 17-50.

McGlynn, P., and Lloyd, R. G. (2002b). Replicating past lesions in DNA. Mol Cell 10, 700-701.

 

Cancer

Lynch, H. T., Smyrk, T., and Lynch, J.(1997). An update of HNPCC (Lynch syndrome). Cancer Genet Cytogenet 93, 84-99.