Lecture 1 Reading

Most relevant

Huang, M. E., Rio, A. G., Nicolas, A., and Kolodner, R. D. (2003). A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100, 11529-11534.

Strand, M., Prolla, T. A., Liskay, R. M., and Petes, T. D. (1993). Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365, 274-276.

Fishel, R., Lescoe, M. K., Rao, M. R., Copeland, N. G., Jenkins, N. A., Garber, J., Kane, M., and Kolodner, R. (1993). The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75, 1027-1038.

Also interesting

Dunham, M. J., Badrane, H., Ferea, T., Adams, J., Brown, P. O., Rosenzweig, F., and Botstein, D. (2002). Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 99, 16144-16149.

Useful reviews

**Peltomaki, P. (2001). DNA mismatch repair and cancer. Mutat Res 488, 77-85.

Heyer, J., Yang, K., Lipkin, M., Edelmann, W., and Kucherlapati, R. (1999). Mouse models for colorectal cancer. Oncogene 18, 5325-5333.

Kolodner, R. D., Putnam, C. D., and Myung, K. (2002). Maintenance of genome stability in Saccharomyces cerevisiae. Science 297, 552-557.

Lynch, H. T., Smyrk, T., and Lynch, J. (1997). An update of HNPCC (Lynch syndrome). Cancer Genet Cytogenet 93, 84-99.