TUESDAY, FEBRUARY 3, 8:30 AM
Session I
RAD51 --- Josh Veatch
Henry-Mowatt, J., Jackson, D., Masson, J. Y., Johnson, P.
A., Clements, P. M., Benson, F. E., Thompson, L. H., Takeda, S., West, S. C.,
and Caldecott, K. W. (2003). XRCC3 and Rad51 modulate replication fork
progression on damaged vertebrate chromosomes. Mol Cell 11, 1109-1117.
RAD52/54 --Roland Walter
Essers, J., Houtsmuller, A. B., van Veelen, L., Paulusma,
C., Nigg, A. L., Pastink, A., Vermeulen, W., Hoeijmakers, J. H., and Kanaar, R.
(2002). Nuclear dynamics of RAD52 group homologous recombination proteins in
response to DNA damage. Embo J 21,
2030-2037.
BRCA1 --- Qiangwei
Xia
Dong, Y., Hakimi, M. A., Chen, X., Kumaraswamy, E., Cooch,
N. S., Godwin, A. K., and Shiekhattar, R. (2003). Regulation of BRCC, a
holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit
and its role in DNA repair. Mol Cell 12,
1087-1099.
BRCA2 --- Meredith Mathis
Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M.,
Blundell, T. L., and Venkitaraman, A. R. (2002). Insights into DNA
recombination from the structure of a RAD51-BRCA2 complex. Nature 420, 287-293.
FANC---Shinji
Kasahara
Levitus, M., Rooimans, M. A., Steltenpool, J., Cool, N. F.,
Oostra, A. B., Mathew, C. G., Hoatlin, M. E., Waisfisz, Q., Arwert, F., De
Winter, J. P., and Joenje, H. (2003). Heterogeneity in Fanconi anemia: evidence
for two new genetic subtypes. Blood.
FANC D --- Jenn Pang
Houghtaling, S., Timmers, C., Noll, M., Finegold, M. J.,
Jones, S. N., Meyn, M. S., and Grompe, M. (2003). Epithelial cancer in Fanconi
anemia complementation group D2 (Fancd2) knockout mice. Genes Dev 17, 2021-2035.
XRCC1 --- Carol Holman
Whitehouse, C. J., Taylor, R. M., Thistlethwaite, A.,
Zhang, H., Karimi-Busheri, F., Lasko, D. D., Weinfeld, M., and Caldecott, K. W.
(2001). XRCC1 stimulates human polynucleotide kinase activity at damaged DNA
termini and accelerates DNA single-strand break repair. Cell 104, 107-117.
THURSDAY, FEBRUARY 5, 8:30 AM
Session II
MUS81/EME1 --- Nicolle Hamilton
Abraham, J., Lemmers, B., Hande, M. P., Moynahan, M. E.,
Chahwan, C., Ciccia, A., Essers, J., Hanada, K., Chahwan, R., Khaw, A. K.,
et al. (2003). Eme1 is involved in DNA
damage processing and maintenance of genomic stability in mammalian cells. Embo
J 22, 6137-6147.
WRN --- Joe Rogers
Baynton, K., Otterlei, M., Bjoras, M., von Kobbe, C., Bohr,
V. A., and Seeberg, E. (2003). WRN interacts physically and functionally with
the recombination mediator protein RAD52. J Biol Chem 278, 36476-36486.
BLM --- Steve
Reynolds
Wu, L., and Hickson, I. D. (2003). The Bloom's syndrome
helicase suppresses crossing over during homologous recombination. Nature
426, 870-874.
Ku/DNA-PK/Artemis --- Dawn Harris
Karanjawala, Z. E., Adachi,
N., Irvine, R. A., Oh, E. K., Shibata, D., Schwarz, K., Hsieh, C. L., and
Lieber, M. R. (2002). The embryonic lethality in DNA ligase IV-deficient mice
is rescued by deletion of Ku: implications for unifying the heterogeneous
phenotypes of NHEJ mutants. DNA Repair (Amst) 1, 1017-1026.
DNA LIGASE 4 --- Ryan Roper
Frank, K. M., Sharpless, N. E., Gao, Y., Sekiguchi, J. M.,
Ferguson, D. O., Zhu, C., Manis, J. P., Horner, J., DePinho, R. A., and Alt, F.
W. (2000). DNA ligase IV deficiency in mice leads to defective neurogenesis and
embryonic lethality via the p53 pathway. Mol Cell 5, 993-1002.
RAG1/2 --- Colin Havenar-Daughton
Messier, T. L., O'Neill, J. P., Hou, S. M., Nicklas, J. A.,
and Finette, B. A. (2003). In vivo transposition mediated by V(D)J recombinase
in human T lymphocytes. Embo J 22,
1381-1388.
H2AX --- Valerie Morris
Celeste A et al.
(2003) H2AX Haploinsufficiency modifies genomic stability and tumor
susceptibility. Cell 114: 371-383.
FRIDAY, FEBRUARY 6, 2:30 PM
Session III
AID --- Eric Merkley
Chaudhuri, J., Tian, M.,
Khuong, C., Chua, K., Pinaud, E., and Alt, F. W. (2003). Transcription-targeted
DNA deamination by the AID antibody diversification enzyme. Nature 422, 726-730.
APOBECS --- Greg Brennan
Mangeat, B., Turelli, P.,
Caron, G., Friedli, M., Perrin, L., and Trono, D. (2003). Broad antiretroviral
defence by human APOBEC3G through lethal editing of nascent reverse
transcripts. Nature 424, 99-103.
Pol eta --- Dan Gestaut
Zheng, H., Wang, X., Warren,
A. J., Legerski, R. J., Nairn, R. S., Hamilton, J. W., and Li, L. (2003).
Nucleotide excision repair- and polymerase eta-mediated error-prone removal of
mitomycin C interstrand cross-links. Mol Cell Biol 23, 754-761.
Pol iota --- Cynthia Glover
Faili, A., Aoufouchi, S., Flatter,
E., Gueranger, Q., Reynaud, C. A., and Weill, J. C. (2002). Induction of
somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase
iota. Nature 419, 944-947.
RAD51 Paralogues ---
Michelle Shimogawa
Liu, N., Schild, D., Thelen,
M. P., and Thompson, L. H. (2002). Involvement of Rad51C in two distinct
protein complexes of Rad51 paralogs in human cells. Nucleic Acids Res 30, 1009-1015.
RAD51C/XRCC3
Liu et al., 2004 ---
Laura Sycuro
Liu, Y., Masson, J. Y.,
Shah, R., O'Regan, P., and West, S. C. (2004). RAD51C is required for Holliday
junction processing in mammalian cells. Science 303, 243-246.
FRIDAY, FEBRUARY 6, 4:00 PM
Session IV
TFIIH --- Angela Shaulov
Dubaele, S., Proietti De Santis, L., Bienstock, R. J.,
Keriel, A., Stefanini, M., Van Houten, B., and Egly, J. M. (2003). Basal
transcription defect discriminates between xeroderma pigmentosum and
trichothiodystrophy in XPD patients. Mol Cell 11, 1635-1646.
CSB --- Vivian Hawkins
Osterod, M., Larsen, E., Le Page, F., Hengstler, J. G., Van
Der Horst, G. T., Boiteux, S., Klungland, A., and Epe, B. (2002). A global DNA
repair mechanism involving the Cockayne syndrome B (CSB) gene product can
prevent the in vivo accumulation of endogenous oxidative DNA base damage.
Oncogene 21, 8232-8239.
XPD --- Johanna Eddy
de Boer, J., Andressoo, J. O., de Wit, J., Huijmans, J.,
Beems, R. B., van Steeg, H., Weeda, G., van der Horst, G. T., van Leeuwen, W.,
Themmen, A. P., et al. (2002).
Premature aging in mice deficient in DNA repair and transcription. Science
296, 1276-1279.
ERCC1/XPF --- Deidre L. Golej
Niedernhofer, L. J.,
Essers, J., Weeda, G., Beverloo, B., de Wit, J., Muijtjens, M., Odijk, H.,
Hoeijmakers, J. H., and Kanaar, R. (2001). The structure-specific endonuclease
Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.
Embo J 20, 6540-6549.
Ubiquitin, Sumo --- Di Kim
Meetei, A. R., de Winter, J. P., Medhurst, A. L., Wallisch,
M., Waisfisz, Q., van de Vrugt, H. J., Oostra, A. B., Yan, Z., Ling, C.,
Bishop, C. E., et al. (2003a). A novel
ubiquitin ligase is deficient in Fanconi anemia. Nat Genet 35, 165-170.
ATM --- Eric Herbig
Bakkenist, C. J., and Kastan, M. B. (2003). DNA damage
activates ATM through intermolecular autophosphorylation and dimer dissociation.
Nature 421, 499-506.
ATR --- Terri
Sundsvold
Costanzo, V., Shechter, D., Lupardus, P. J., Cimprich, K.
A., Gottesman, M., and Gautier, J. (2003). An ATR- and Cdc7-dependent DNA
damage checkpoint that inhibits initiation of DNA replication. Mol Cell 11, 203-213.
P53 ---Ashok Bandaranayake
Zhu, C., Mills, K. D., Ferguson, D. O., Lee, C., Manis, J.,
Fleming, J., Gao, Y., Morton, C. C., and Alt, F. W. (2002). Unrepaired DNA
breaks in p53-deficient cells lead to oncogenic gene amplification subsequent
to translocations. Cell 109, 811-821.
HAPPY HOUR, 5:30 -----