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Critically Appraised Topics: THERAPY (February 08) In a 47 year old woman with migraine headaches occurring at least 4 times per month and who was initially placed on venlafaxine for depression, would switching to amitriptyline offer any advantage in decreasing the frequency and severity of migraine headaches? (January 08) In a 45-year-old Caucasian man with a 20-PY history of smoking, what is the benefit of varenicline (Chantix) vs. buproprion for smoking cessation after one year? (November 07) In a 60 y.o. patient with chronic low back pain, do topical lidocaine patches such as Lidoderm decrease pain scores and/or improve functional status? (September 07) In a 50 year old male with LBP of 12 weeks duration what is the benefit of physical therapy versus no physical therapy (allowing for pain relief with NSAIDS and activity as tolerated) on improved functionality (return to work versus scores of physical performance?) and pain? (February 07) In a 60 yo woman with T-score of -3.0 but no other risk factors for fracture, what is the benefit of bisphosphonate therapy for prevention of hip fractures? (January 07) In a 45 yo man w/ urinary hesitancy, what is the efficacy of doxazosin (vs no treatment) in the relief of urinary symptoms?
(October
06)
In
a 60 you man w/ osteoarthritis, what is the benefit of nabumetone versus
other NSAIDs in relief of pain?
(August 06) In a 64 year old woman with genital herpes, does chronic suppressive therapy will valacyclovir decrease the rate of transmission? (July 06) 47 year old male 1 month s/p IMI presents with clinically with symptoms of anxiety and depression, does treatment prevent recurrence of acute coronary syndrome? (May 06) In a Type 2 diabetic requiring insulin therapy, does the addition of oral hypoglycemic agents improve glycemic control? (March 06) In a 55 yo male with gram negative bacteremia, what is the benefit of double covering vs. single coverage on mortality (or hospital days)? (January 06) In a 45 year old woman with first time major depressive episode and wary of taking medication, does combination of medication and psychotherapy reduce the duration of treatment with medication or otherwise improve response to therapy (less depressive symptoms)? (November 05) In a 51 year-old African-American woman with HCV, increased AST and ALT, but without cirrhosis, what's the benefit of interferon vs. placebo in preventing progression to cirrhosis? In patients with chronic back pain on narcotics, will antidepressant therapy improve pain control? (August 05)
In patients with ascites due to chronic liver disease, what is the benefit of primary prophylaxis with weekly ciprofloxacin in reducing the risk of SBP? (July 05)
In a 77 year old man with hypertension and presumed hypertensive nephropathy (creatinine 1.7) does the use of ace inhibitor to control high blood pressure rather than other medications delay further decline in renal function? (May 05)
In adult patients with tense ascites undergoing large volume paracentesis, does the concomitant administration of albumin improve morbidity and mortality over placebo?
Do oral antibiotics improve time to recovery in patients with soft tissue abscesses treated with incision and drainage? (March 05)
In a 50 year-old woman with an indwelling central venous catheter for chemotherapy does the use of low dose coumadin prevent complication from line related thrombosis? (February 05)
In adult patients with severe sepsis, what is the effect of activated protein C (drotrecogin alfa) in reducing mortality? (January 05)
In patients with diabetes requiring insulin, does the addition of metformin improve outcomes (endpoint : death, non-fatal MI, CVA, revascularization, etc.)?
Update this search in PubMed* (November 04)
In bacterial vaginosis, is metronidazole PV as effective as metronidazole PO at reducing duration of symptoms?
Update this search in PubMed*
Is there a notable difference in risk of the disulfiram type reaction?
Update this search in PubMed* (October 04)
Does therapy with aspirin reduce cardiovascular events in asymptomatic women compared with placebo?
Update this search in PubMed* (September 04)
In patients with diabetes and painful peripheral neuropathy, does treatment with gabapentin reduce pain?
Update this search in PubMed* (August 04)
In elderly patients (age 65 or greater) with major depression, which class of antidepressants are most effective at relieving symptoms of depression?
Update this search in PubMed*
In HIV positive patients with recurrent genital herpes, does chronic suppressive therapy with oral valacyclovir decrease frequency and duration of recurrences compared with placebo?
Update this search in PubMed*(July 04)
In Type II diabetics without amputation (primary prevention), does the use of a screening program and foot care specialist reduce the risk of amputation?
Update this search in PubMed*
*This embedded search was created by Sherry Dodson, Clinical Medical Librarian at the UW Health Sciences Libraries. The link will take you directly to current and relevant citations in PubMed which automatically update as new studies are published and indexed. If you would like to see the search terms used, click on the Details tab in PubMed. The search strategy can be seen at the bottom under User Query.
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