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Autumn
Quarter, 2000 - MWF 11:30-12:20, T-635
Discussion
Section, Selected Tuesdays, 1:30-2:20, T-733
Course
Directors:
Dr.
Curt Omiecinski, Professor, Room R207, Phone 543-1700
email:
cjo@u.washington.edu
Dr.
Zhengui Xia, Assistant Professor, Room HSB-F561C, Phone 616-9433
email:
zxia@u.washington.edu
TA:
Jennifer Finley, email:
jennfin@u.washington.edu
Course
Overview: In this class, students will explore the mechanisms
and fate of chemical interaction with biological systems. With the
information gathered from this class, students will derive an enhanced
appreciation for how foreign chemicals, including pharmaceuticals
and environmental agents, interact with cellular pathways to effect
toxicological insult. Guest lecturers are a valuable asset to the
course and will assist to provide coverage of subject areas within
their respective areas of expertise.
The
514 class is the first quarter of a 3 quarter course series. None
of the individual classes are intended as stand-alone courses. Together,
the 3 quarter sequence integrates core subject areas pertaining
to environmental and occupational toxicology. The second quarter
(ENVH 515) of the continuing class sequence focuses primarily on
organ system toxicology, while the emphasis of the third
quarter (ENVH 516) is on specific classes of toxicological
agents.
ENVH
514 is organized with modules pertaining to:
- Dose-response
theory;
- Concepts
of risk assessment;
- Absorption
& distribution of toxicants;
- Signal
transduction pathways;
- Biochemical
& molecular mechanisms of toxicity;
- Genetic
toxicology;
- Metabolism/biotransformation;
- Cell
Death & Apoptosis;
- Gene
induction;
- Carcinogenesis;
- Toxicokinetics;
and
- Genetic
Polymorphism.
Intended
Student Audience: The ENVH 514/515/516 course sequence serves
as the core of the toxicology program for Toxicology graduate students
in the Department of Environmental Health. Graduate students from
other allied biomedical science departments, e.g., Epidemiology,
Medicinal Chemistry, Chemistry, Molecular & Cellular Biology,
also participate in the course on a regular basis. Prerequisites
for this class include a year of undergraduate general biology,
two quarters of organic chemistry, and two quarters of graduate
level biochemistry, the second quarter of which may be taken concurrently.
Previous background or concurrent registration in mammalian physiology
is strongly recommended.
Required
Reading: The text for ENVH 514 is: Casarett and Doull's Toxicology:
the Basic Science of Poisons, Fifth Edition, and is available at
the Health Sciences Branch of the University Bookstore. The same
text also is used in the 515 and 516 sections of this course.
Additional
handout materials will be provided for most classes and are required
reading.
Discussion
Groups: At several points in the quarter, a discussion section
will meet on Tuesday, from 1:30-2:20 PM, in T-733. Ms. Jennifer
Finley will direct the discussion groups with assistance
from Drs. Omiecinski, Xia and guest lecturers. These sessions will
provide an opportunity for review of course materials prior to exams
and other extended discussion of course subject matter.
Grading:
The final grade for this class will be compiled from 2 in-class
exams and 2 take-home exams.
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