Melanocytes week 14

Melanocytes begin to make pigment

DOPA-positive melanocytes are present in non-Caucasian epidermis but are few in number. Melanocytes appear about two weeks later in Caucasian epidermis. Initiation of melanocyte function proceeds in a cephalocaudal direction.

DOPA-positive melanocyte

The DOPA reaction signifies the presence of the complete metabolic pathway to melanin synthesis. This reaction occurs in the signature structural granule of the melanocyte.