Eric Seibel, Ph.D.
Department of Mechanical Engineering (Human Interface
"Mechanics of Automated 3D Microscopy for Early Cancer Detection"
An optical projection tomography microscope has been developed
which can be thought of an
optical CT-scanner of cells and bare nuclei within a microfluidics
chamber. The mechanics
involved are cell biomechanics during automated cell preparation, the
fluid mechanics of cells
within small capillaries that are constantly rotated, and the
opto-mechanics of imaging across
360 degrees with sub-micron error. The challenge is to make this
current prototype system a
high-throughput instrument for lung cancer screening.