Eric Seibel, Ph.D.
Department of Mechanical Engineering (Human Interface Technology Lab)
"Mechanics of Automated 3D Microscopy for Early Cancer Detection"


ABSTRACT

An optical projection tomography microscope has been developed which can be thought of an
optical CT-scanner of cells and bare nuclei within a microfluidics chamber.  The mechanics
involved are cell biomechanics during automated cell preparation, the fluid mechanics of cells
within small capillaries that are constantly rotated, and the opto-mechanics of imaging across
360 degrees with sub-micron error.  The challenge is to make this current prototype system a
high-throughput instrument for lung cancer screening.