Course is offered every quarter.

Course Coordinators:

The course coordinator changes every quarter.

Time:

4:00-5:00 PM Mondays

Room:

H-074

Course Description

Discussion of pertinent articles from current literature. Credit/no-credit only.

Spring 2019 Schedule

Coordinator: Mike Guttman

The theme for this quarter will be: Tutorials and Research Practicals

Date Topic Supplemental Information
Apr 8 Making figures, illustrator examples Making Effective Scientific Figures
Apr 15 Publication insights & quick tutorial on PyMOL Publication Notes
PyMOL Basics
Apr 22 3D printers & material compatibility Material Combatibility
3D Printers
Apr 29 Modern approaches to cloning and DNA sequencing Cloning Overview
May 6 Linux and DOS basics Operating Systems
MSDOS
May 13 Model selection and fitting
Excel Example		 Model Selection and Fitting
Data Fitting Using Excel
May 20 Rotation talks (20 min each)  
May 27 No meeting (Memorial day)  
Jun 3 Practical aspects and best practices with light spectroscopy  

Winter 2019 Schedule

Coordinator: Libin Xu

The theme for this quarter will be: Focus on grant writing.
Presenter should write a short proposal and present it (white board preferred, powerpoint and/or handouts allowed). Three students serve as primary peer reviewers, but all will have a chance to provide feedback in class.

Please send PDF versions of your papers to Sarah on the Wednesday before MNM.

Date Presenter Paper
(Click title to download PDF)		 Supplemental Information
Jan 7 No Meeting    
Jan 14 Libin Xu NIH Grant Writing and Peer Review Peer Review Form
Jan 21 No Meeting MLK Holiday  
Jan 28 Ben Maldonato (Totah) Maldonato Proposal on Canvas site  
Feb 4 Mark Benhaim (Lee) Benhaim Proposal on Canvas site  
Feb 11 John Kowalski (Rettie) Kowalski Proposal on Canvas site  
Feb 18 No Meeting President's Day Holiday  
Feb 25 Amy Li (Xu) Li Proposal on Canvas site  
Mar 4 Eddie Hodge (Lee) Hodge Proposal on Canvas site  
Mar 11 Mike Watson (Guttman) Watson Proposal will be posted on Canvas site  

Autumn 2018 Schedule

Coordinator: Rheem Totah

Please send PDF versions of your papers to Sarah on the Wednesday before MNM.

Date Student Moderator Faculty Moderator Paper
(Click title to download PDF)		 Supplemental Information
Oct 1 No Meeting      
Oct 8 Christi Cho Totah Posttranslational regulation of CYP2J2 by nitric oxide  
Oct 15 Hayli Larsen Totah Clinical Measurement of von Willebrand Factor by Fluorescence Correlation Spectroscopy  
Oct 22 Quynh Do Totah Peroxyl Radical Clocks Discussion Questions
Oct 29

Taylor Murphree

Totah A Description of the Glass Electrode and its use in Measuring Hydrogen Ion Concentration. and A formula for correlating pKa values determined in D2O and H2O.  
Nov 5 Tianwei Shen Totah Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids  
Nov 12 No Meeting   Veteran's Day Holiday  
Nov 19 Clint Vorauer Totah Generation, Characterization, and Epitope Mapping of Neutralizing and Protective Monoclonal Antibodies against Staphylococcal Enterotoxin B-induced Lethal Shock  
Nov 26 Dylan Ross Totah Large-Scale Prediction of Collision Cross-Section Values for Metabolites in Ion Mobility-Mass Spectrometry and LipidCCS: Prediction of Collision Cross-Section Values for Lipids with High Precision to Support Ion Mobility-Mass Spectrometry-Based Lipidomics  
Dec 3 Lorela Paço Totah Dissociation Constants of Cytochrome P450 2C9/Cytochrome P450 Reductase Complexes in a Lipid Bilayer Membrane Depend on NADPH: A Single-Protein Tracking Study  

Spring 2018 Schedule

Coordinator: Bill Atkins

Please send PDF versions of your papers to Sarah on the Wednesday before MNM.

The theme for this quarter will be: Papers that changed the way you think about your project other than methodology.

Date Student Moderator Faculty Moderator Paper
(Click title to download PDF)		 Supplemental Information
Apr 9 Li Atkins Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis  
Apr 16 Hodge Atkins The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans  
Apr 23 Watson Atkins Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen Supplemental Info
Apr 30 Paco Atkins Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs  
May 7 Murphree/Shen Atkins   rotation talks
May 14 Do/Cho Atkins   rotation talks
May 21 Vorauer/Larsen Atkins   rotation talks
May 28 No Meeting   Memorial Day Holiday  

Winter 2018 Schedule

Coordinator: Abhinav Nath

The theme for this quarter will be:
Papers that overnturned a pre-existing paradigm in their field.

Date Student Moderator Faculty Moderator(s) Paper
(Click title to download PDF)		 Supplemental Information
Jan 8 No Meeting      
Jan 15 No Meeting   MLK Holiday  
Jan 22 Evangelista Nath Efficient Hypoxic Activation of the Anticancer Agent AQ4N by CYP2S1 and CYP2W1  
Jan 29 Ross Nath Structural basis of Smoothened regulation by its extracellular domains  
Feb 5 Aliwarga Nath Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis  
Feb 12 Baughman Nath Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease  
Feb 19 No Meeting   President's Day Holiday  
Feb 26 Redhair Nath Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics;  
Mar 5 Williams Nath Antibody-Dependent Enhancement of Dengue Virus Infection in Primary Human Macrophages; Balancing Higher Fusion against Antiviral Responses  

Autumn 2017 Schedule

Coordinator: Kent Kunze

The theme for this quarter will be:
Reproducibility and Science and Scientific Literature

Date Student Moderator Faculty Moderator(s) Paper
(Click title to download PDF)		 Supplemental Information
Oct 2 No Meeting      
Oct 9 No Meeting      
Oct 16 Kowalski Kunze Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy  
Oct 23 Benhaim Kunze Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer  
Oct 30 Maldonato Kunze Cancer sniffer dogs: how can we translate this peculiarity in laboratory medicine? Results of a pilot study on gastrointestinal cancers  
Nov 6 Pelletier Kunze Comparative assessment of bioanalytical method validationguidelines for pharmaceutical industry Supplemental Articles
Nov 13 Isoherranen Kunze
  • Science journal editors’ views on publication ethics: results of an international survey
  • How Many Scientists Fabricate and Falsify Research? A Systematic Review and Meta-Analysis of Survey Data
    		•  NIH notice about choosing journals
    Nov 20 TBD      
    Nov 27 Goulet Kunze A global benchmark study using affinity-based biosensors  
    Dec 4 Baggett Kunze Screening in a spirit-haunted world  

    Spring 2017 Schedule

    Coordinator: Mike Guttman

    The theme for this quarter will be: CRISPR & PCSK9 Inhibitors

    Please continue to follow all of the guidelines below. Papers must be made available online by the Thursday before MNM so send PDF versions of your papers to Sarah on Wednesdays.

    Follow these guidelines for your presentation, no exceptions:


    Date Student Moderator Faculty

    Paper
    (Click title to download PDF)

    		 Supplemental Information
    Mar 27     No Meeting  
    Apr
    3    		 Rob Libin & Mike Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition CAR T Cells - Supplemental
    Apr 10 Mark Rheem & Libin Multi-input CRISPR/Cas genetic circuits that interface host regulatory networks  
    Apr 17 James Kent & Abhi Engineering Complex Synthetic Transciptional Programs with CRISPR RNA Scaffolds  
    Apr 24 Lorela Kent & Rheem Nucleic acid detection with CRISPR-Cas13a/C2c2 Supplemental Materials
    May 1 Michelle Abhi & Kelly Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor  
    May 8 Dylan Mike & Bill In vivo genome editing using Staphylococcus aureusCas9  
    May 15 Amy and Mike   Rotation Talks  
    May 22 Eddie   Rotation Talks  
    May 29     No Meeting - Memorial Day  

    Winter 2017 Schedule

    Coordinators: Eri Nakatani-Webster (Kelly Lee)

    The theme for this quarter will be: “What can structure tell us and what can’t it tell us about biological and enzymatic function?”

    Please continue to follow all of the guidelines below. Papers must be made available online by the Thursday before MNM so send PDF versions of your papers to Sarah on Wednesdays, but they do not need to be submitted to Eri for review first.

    Follow these guidelines for your presentation, no exceptions:

    Additionally, Ben and Ryan have volunteered to present a 1-2 page writing sample to be workshopped. The samples will be available under Supplemental Information, along with a feedback form to be completed by the readers. Please be prepared to hand it in on the day of the workshop.


    Date Student Moderator Faculty

    Paper
    (Click title to download PDF)

    		 Supplemental Information
    Jan 2     No Meeting  
    Jan 9 Dennis Mike, Libin Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential Supplemental Information
    Jan 16     MLK Day – No Meeting  
    Jan 23 John Abhi, Rheem Mechanism of Inactivation of Neuronaal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetemidamido)pentanoic Acid  
    Jan 30 Ben Rheem Ben's Workshop (feedback form)  
    Feb 6 David Libin, Mike Remarkably Fast Coupled Folding and Binding of the Intriniscally Disordered Transactivation Domain of CMyb to CBP KIX Supplemental Information
    Feb 13 Eric Kelly, Kent Structures of Human Steroidogenic Cytochrome P450 17A1 with Substrates  
    Feb 20     Presidents Day – No Meeting  
    Feb 27 Rob Kelly, Abhi TBA  
    Mar 6 Ryan Kent Ryan's Workshop (feedback form) Writing Sample

    Autumn 2016 Schedule

    Coordinator: Eri Nakatani-Webster (Allan Rettie)

    This quarter, select a paper that nicely showcases the technique of your choosing. It can be one you are already familiar with, or something you have been interested in learning more about. Please come prepared to thoroughly explain this technique to your peers.

    We will be returning to the newer MNM format. Please e-mail papers to Sarah Lenti to be posted to the website after they are approved.

    Follow the guidelines below for your presentation, no exceptions:

    Feel free to contact Eri Nakatani-Webster with any questions or concerns.

    Date Student Moderator Faculty Moderator(s) Paper
    (Click title to download PDF)    		 Supplemental Information
    Oct 3     No Meeting  
    Oct 10 Mark Benhaim Rheem, Mike Folding of a Large Protein at High Structural Resolution  
    Oct 17 James Williams Abhi, Mike Native structure of a retroviral envelope protein and its conformational change upon interaction with the target cell  
    Oct 24 Kelly Hines (Postdoc) Libin Research Presentation: HILIC-IM-MS Reveals Altered Bacterial Lipidome in Antimicrobial Resistance  
    Oct 31 Lorela  Paço Kelly, Kent Visualizing the kinetic power stroke that drives proton-coupled zinc(II) transport Supplemental Information
    Nov 7 Mavis Li Rheem, Libin The uncoupled ATPase activity of the ABC transporter BtuC2D2 leads to a hysteretic conformational change, conformational memory, and improved activity  
    Nov 14 Eri Nakatani-Webster (Postdoc) Abhi Building mechanistic models from kinetic data: adventures in amyloid formation  
    Nov 21 Michelle Redhair Allan, Kelly Revisiting the Metabolism of Ketoconazole Using Accurate Mass  
    Nov 28     No Meeting - Thanksgiving  
    Dec 5 Dylan Ross Allan, Kent Travelling-wave ion mobility mass spectrometry and negative ion fragmentation of hybrid and complex N-glycans  

    Spring 2016 Schedule

    Coordinator: Wendel Nelson

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Mar 28 No MNM    
    Apr 4 Ryan Seguin Bioactivation of 5F and GW and Deactivation by CYP2S1 Supporting Information
    Apr 11 Wynton McClary Identification of the Residue in Human CYP3A4 That is Covalently Modified by Bergamottin and the Reactive Intermediate That Contributes to the Grapefruit Juice Effect  
    Apr 18 Eric Evangelista Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associtated DNA adducts using UPLC-MS/MS methods  
    Apr 25 Dennis Goulet A New Mechanism of Action for the Anticancer Drug Mitomycin Mechanism-Based Inhibition of Thioredoxin Recutase Supporting Information
    May 2 David Baggett Role of cytochrome P450-mediated metabolism and identification of novel thiol-conjugated metabolites in mice with phenytoin-induced liver injury  
    May 9 Lorela Paco Presentation re rotation in Atkins lab.  
    May 16 Dylan Ross Presentation re first-year lab rotations.  
    May 23 No MNM    
    May 30 No MNM HOLIDAY  

    Winter 2016 Schedule

    Coordinator: Libin Xu

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Jan 4 No MNM    
    Jan 11 General discussion on MNM and NIH Grant Review Process NCURA OER Grant Process-At-A-Glance Supplemental information
    Jan 18 No MNM, MLK day    
    Jan 25 James Williams Relating Virus fusion kinetics to stoichiometry of neutralizing antibodies Attending faculty:
    Nath, Atkins
    Feb 1 Mavis Li Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ Attending faculty:
    Rettie, Kunze
    Feb 8 Hannah Baughman Sites of Tau Important for Aggregation Populate β-Structure and Bind to Microtubules and Polyanions Attending faculty:
    Atkins, Lee
    Feb 15 No MNM, Presidents' Day    
    Feb 22 Eleanor Vane Simultaneous Single-Molecule Fluorescence and Conductivity Studies Reveal Distinct Classes of Aβ Specieson Lipid Bilayers Attending faculty:
    Lee, Totah
    Feb 29 Theresa Aliwarga Cytochrome P450 system proteins reside in different regions of the endoplasmic reticulum Attending faculty:
    Kunze, Nath
    Mar 7 Josi Herron Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds Attending faculty:
    Totah, Rettie

    Autumn 2015 Schedule

    Coordinator: Eri Nakatani-Webster (Rheem Totah)

    This quarter, we ask that you present a paper that is central to your research, and one you refer back to often -- perhaps a critical study that helped form the basis of your project, or one that is focused around a technique or system that is of great importance to your work. The idea is to play to your own strengths -- choosing a paper you are familiar with will help ensure it is a quality publication, while giving the new students a chance to acquaint themselves with everyone's projects and areas of expertise.

    We encourage you to present newer papers, but if you can make a good case for one that is over 20 years old, we are open to discuss it. Please refrain from presenting review articles and publications coming from your own lab.

    We will be trying a radically different, PowerPoint-free format for Monday Night Meeting this quarter. Rather than a presentation, please prepare a number of talking points you'd like to discuss with the group. More details will come during the October 5 discussion.

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Oct 5 Discussion Discussion: The importance of stupidity in scientific research  
    Oct 12 Rob Pelletier
    (Totah, Rettie)    		 Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450  
    Oct 19 Eric Evangelista
    (Kunze, Xu)    		 Electrophysiological Properties of Cardiomyocytes Isolated from CYP2J2 Transgenic Mice  
    Oct 26 Dennis Goulet
    (Nath, Lee)    		 Mechanism of Immunoglobulin G4 Fab-arm Exchange Supporting Information
    Nov 2 Ben Maldonato
    (Xu, Rettie)    		 Hepatic Microsomal Thiol Methyltransferase Is Involved in Stereoselective Methylation of Pharmacologically Active Metabolite of Prasugrel  
    Nov 9 Michelle Redhair
    (Kunze, Xu)    		 The kinetic mechanism for cytochrome P450 metabolism of Type II binding compounds: Evidence supporting direct reduction  
    Nov 16 John Kowalski
    (Atkins, Totah)    		 Metabolism of Furans in Vitro: Ipomeanine and 4-Ipomeanol  
    Nov 23 NO MNM    
    Nov 30 Mark Benhaim
    (Nath, Totah)    		 Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin  
    Dec 7 David Baggett
    (Atkins, Lee)    		 Identification of small-molecule binding pockets in the soluble monomeric form of the AΒ42 peptide  

     

    Spring 2015 Schedule

    Coordinator: Kent Kunze

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Apr 13 Ryan Seguin Carbon Radicals in the Metablism of Alkyl Hydrazines  
    Apr 20 James Williams Virus Capsid Expansion Driven by the Capture of Mobile Surface Loops  
    Apr 27 Wynton McClary Metabolic Switching in Cytochrome P-450cam: Deuterium Isotope Effects on Regiospecificity and the Monooxygenase/Oxidase Ratio  
    May 4 Hannah Baughman
    David Baggett    		 The Conformational Ensembles of α-Synuclein and Tau: Combining Single-Molecule FRET and Simulations Supplemental information
    May 11 Ben Maldonato    
    May 18 Mark Behnaim    
    May 25 HOLIDAY NO MNM  
    Jun 1 John Kowalski  TBD  

    Winter 2015 Schedule

    Coordinator: Abhinav Nath

    Guidelines for choosing a paper: Your paper should describe at least one conceptual or technical breakthrough. You should be prepared to discuss exactly what elevates your choice over a routine paper in the field. We're looking for good papers that challenge us and teach us something new, rather than for run-of-the-mill papers that may be easier to tear down. They don't necessarily have to be recent - if you have a classic paper that you'd like to share, bring it on.

    I suggest taking the time to explain how any non-routine techniques or assays work. A common theme in many of the survey responses is that unfamiliarity with techniques is an obstacle to appreciating papers that are out of one's comfort zone.

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Jan 5   NO MNM  
    Jan 12 All Open discussion about the peer review process Slides and useful links
    Jan 19 HOLIDAY NO MNM  
    Jan 26 Natalie Garcia Amphipols Outperform Dodecylmaltoside Micelles in Stabilizing Membrane Protein Structure in the Gas Phase  
    Feb 2 Lucas Monkkonen The Orbitrap: a new mass spectrometer  
    Feb 9 David Baggett A new antibiotic kills pathogens without detectable resistance Supplemental information
    Feb 16 HOLIDAY NO MNM  
    Feb 23 Eric Evangelista A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents Supplemental information
    Mar 2 Dennis Goulet Generation of bispecific lgG antibodies by structure-based design of an orthogonal Fab interface Supplemental information
    Mar 9 Amanda Johnson AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges  

    Autumn 2014 Schedule

    Coordinator: Carlos Catalano

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Oct 6 Theresa Aliwarga Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury  
    Oct 13 Long Gui Structure of the TRPV1 ion channel determined by electron cryo-microscopy Supplemental information
    Oct 20 Mavis Li Biacore analysis with stabilized GPCRs  
    Oct 27 Michelle Redhair (1) Active site proton delivery and the lyase activity of human CYP17A1; (2) Mechanism of the Third Oxidative Step in the Conversion of Androgens to Estrogens by Cytochrome P450 19A1 Steroid Aromatase  
    Nov 3 James Williams Kinetic Analysis of Lauric Acid Hydroxylation by Human Cytochrome P450 4A11  
    Nov 10 Rob Pelletier Reduction of Sulfamethoxazole Hydroxylamine (SMX-HA) by the Mitochondrial Amidoxime Reducing Component (mARC)  
    Nov 17 NO MNM NO MNM  
    Nov 24 Ryan Seguin Enzymatic and Cryoreduction EPR Studies of the Hydroxylation of Methylated Nω-Hydroxy-L-arginine Analogues by Nitric Oxide Synthase from Geobacillus stearothermophilus  
    Dec 1 Wynton McClary Investigations of Heme Ligation and Ligand Switching in Cytochromes P450 and P420  

    Spring 2014 Schedule

    Coordinator: William Atkins

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Apr 7 NO MNM NO MNM  
    Apr 14 Grant Barker 1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9  
    Apr 21 Amanda Johnson Menadione (Vitamin K3) is a Catabolic Product of Oral Phylloquinone (Vitamin K1) in the Intestine and a Circulating Precursor of Tissue Menaquinone-4 (Vitamin K2) in Rats  
    Apr 28 Natalie Garcia pH-Controlled Two-Step Uncoating of Influenza Virus Supplemental Information
    May 5 Lucas Monkkonen Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading Supplemental Information
    May 12 Dennis Goulet    
    May 19 David Baggett    
    June 2 Eric Evangelista    

    Autumn 2013 Schedule

    Coordinator: Allan Rettie

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Oct 7 Eri Nakatani-Webster Palmitoylation regulates raft affinity for the majority of integral raft proteins Supporting Information
    Oct 14 Grant Barker Interactions between CYP2E1 and CYP2B4: Effects on Affinity for NADPH-Cytochrome P450 Reductase and Substrate Metabolism  
    Oct 21 Nick Au Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces  
    Oct 28 Natalie Garcia Fast Photochemical Oxidation of Proteins and Mass Spectrometry Follow Submillisecond Protein Folding at the Amino-Acid Level Supporting Information
    Nov 4 Theresa Aliwarga Maternal and Fetal Epoxyeicosatrienoic Acids in Normotensive and Preeclamptic Pregnancies Supplemental Material
    Nov 11 HOLIDAY NO MNM  
    Nov 18 Long Gui Vinylogous chain branching catalysed by a dedicated polyketide synthase module  
    Nov 25 Mavis Li Human P-glycoprotein Contains a Greasy Ball-and-Socket Joint at the Second Transmission Interface  
    Dec 2 NO MNM NO MNM  

     

    Spring 2013 Schedule

    Coordinator: Wendel Nelson

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Apr 15 Amanda Johnson Formation, Reactivity, and Antiplatelet Activity of Mixed Disulfide Conjugates of Clopidogrel Supplemental Information
    Apr 22 Wynton McClary Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients Supplemental Information
    Apr 29 Ryan Seguin Quinone-Induced Activation of Keap1/Nrf2 Signaling by Aspirin Prodrugs Masquerading as Nitric Oxide Supplemental Information
    May 6 Shannon Kruse Selective Estrogen Receptor Modulator (SERM) Lasofoxifene Forms Reactive Quinones Simmilar to Estradiol  
    May 13 Aaron Teitelbaum Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation  
    May 20 NO MNM NO MNM  
    May 27 HOLIDAY NO MNM  
    Jun 3 Rotation Talks NOTE: Begins at 3:30 p.m.  

    Winter 2013 Schedule

    Coordinator: Rheem Totah

    Date Speaker Paper (Click title to download PDF) Supplemental Information
    Jan 14 Long Gui A broad-spectrum antiviral targeting entry of enveloped viruses  
    Jan 21 HOLIDAY NO MNM  
    Jan 28 Grant Barker CYP2D6-CYP2C9 Protein-Protein Interactions and Isoform-Selective Effects on Substrate Binding and Catalysis  
    Feb 4 Nick Au Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone  
    Feb 11 Jean Dinh Minor Activities and Transition State Properties of the Human Steroid Hydroxylases Cytochromes P450c17 and P450c21, from Reactions Observed with Deuterium-Labeled Substrates  
    Feb 18 HOLIDAY NO MNM  
    Feb 25 Mavis Li Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans  
    Mar 4 Theresa Aliwarga Cytochrome P450 Subfamily 2J Polypeptide 2 Expression and Circulating Epoxyeicosatrienoic Metabolites in Preeclampsia  
    Mar 11 Lucas Monkkonen Molecular Model of a Soluble Guanylyl Cyclase Fragment Determined by Small-Angle x-ray Scattering and Chemical Cross-Linking  

     

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