Neural Engineering (BIOEN 499C) homepage
When: Fall 2007, MWF 3:30-4:20 P.M.
Where: Bagley 331A (see map) or Foege Bldg. (depending on lecturer).
Handouts: provided as PDFs in this website at least one class day before the lectures.
Assignments: online quizzes/essays given at the end of each section or sub-section.
Grading: assignments and class participation (+/- 0.1 points).
Pre-requisites: None specifically.
Textbook: (not mandatory, but it's a good one for ~50% of the material) "Neural Engineering" by Bin He (ed.), Kluwer Academic / Plenum Press. There is one copy reserved for the course at the Engineering Library. If "neuron" and "ion channel" do not mean anything to you, start with Brainfacts, a quick introduction to the nervous system.
Important note for disabled individuals: If you would like to request academic accommodations due to a disability, please contact Disabled Student Services, 448 Schmitz, (206) 543-8924 (V/TTY). If you have a letter from Disabled Student Services indicating you have a disability that requires academic accommodations, please present the letter to me so we can discuss the accommodations you might need for the class.
Broad description: This course introduces students to the broad field of neural engineering. The course is approximately divided in three sections: 1) Technologies for monitoring neural activity in vivo (whole brain, from human to small animals) and in vitro (from slices to dissociated cells); discussion of challenges associated with device portability, accessibility of stimulation site, and stimulation scale; wireless EEG, fMRI, microfabricated electrode arrays (MEAs), patch clamp electrophysiological recordings, patch clamp chips, calcium imaging; 2) Technologies for stimulation of neurons in vivo (cortical microelectrodes) and in vitro (patch clamp, iontophoresis, uncaging, microfluidics); 3) Devices for replacing or simulating neural function: implantable electrodes, brain-computer interfaces, cochlear implatns, artificial retina, artificial nose, computer simulations of neuronal networks.
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SEPTEMBER
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Monday
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Wednesday
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Friday
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| 26 -- First day: Course basics; Syllabus | 28 -- Flash Introduction to the Nervous System: Anatomy; The Neuron; Electrical Excitability. See slides and "BrainFacts" | |
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OCTOBER
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Monday
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Wednesday
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Friday
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| 1 -- SECTION 1. Monitoring neural activity: Microfabrication fundamentals; microsystems for implantation; biocompatibility. See slides. | 3 -- SECTION 1. Monitoring neural activity: Implantable microelectrodes for small-animal recordings (Guest lecturer: Prof. Karl Bohringer, EE). See slides and Bohringer lab's website. | 5 -- SECTION 1. Monitoring neural activity: Wireless communication devices for neural recording and stimulation (Guest lecturer: Prof. Brian Otis, EE). See slides and Otis lab's website. |
| 8 -- SECTION 1. Monitoring neural activity: Visit to the Bohringer lab; visit to the Otis lab. | 10 -- SECTION 1. Monitoring neural activity: EEG; (Guest lecturer: Dr. John Oakley, Neurology); visit to Dr. Oakley's lab; EEG of a volunteer doing cognitive tasks. See slides. | 12 -- SECTION 1. Monitoring neural activity: Brain imaging. See slides. |
| 15 -- SECTION 1. Monitoring neural activity: Brain imaging. See slides. | 17 -- SECTION 1. Monitoring neural activity (slices and cell culture): Microelectrode arrays, patch clamp technique See slides and movie. | 19 -- SECTION 1. Monitoring neural activity (slices and cell culture): Calcium imaging to monitor ion channel activity. (Guest lecturer: Prof. Fernando Santana, Phys&Biophys.); See slides and movie. |
| 22-- SECTION 2. Stimulating neural cells (in vivo): In Vivo: Implantable electrodes; fundamentals; implantation procedures; a clinical case (UWTV video). See slides. | 24 -- SECTION 2. Stimulating neurons: Cochlear Implants (Guest lecturer: Dr. Jay Rubinstein, BioE). See slides. | 26 -- SECTION 2. Stimulating neural cells (in vitro): Uncaging, iontophoresis, puffing; role of diffusion. See slides and movie. |
| 29 -- SECTION 2. Stimulating neural cells (in vitro): A case study: perfusion systems for olfaction studies. See slides. | 31-- SECTION 2. Stimulating neural cells (in vitro): Microfluidic biochemical stimulation; neuromimetic microdevices. See slides. | |
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NOVEMBER
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Monday
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Wednesday
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Friday
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| 2 -- SECTION 2. Stimulating neural cells (in vitro): manipulation of individual synaptic vesicles (Guest lecturer: Prof. Dan Chiu, Chemistry Dept.) | ||
| 5 -- SECTION 2. Stimulating neural cells (in vitro): Visit to the Folch lab: neuronal cultures in microfluidic gradient, neuromimetic devices | 7 -- SECTION 3. Replacing/Restoring neural function: Radiation therapy. See slides. | 9 -- SECTION 3. Replacing/Restoring neural function: Ultrasound for healing nerves, drug delivery and pain treatment (Guest lecturer: Prof. Pierre Mourad, Dept. of Neurological Surgery). See slides. |
| 12 -- NO CLASS (VETERAN'S DAY) | 14 -- SECTION 3. Replacing/Restoring neural function: Visit to the Daniel lab (Biology Dept.): real-time control of moths | 16 -- SECTION 3. Replacing/Restoring neural function: Neural Prostheses for locomotion and hand grasp (Guest lecturer: Prof. Howard Chizeck, EE dept.). See slides. |
| 19 -- SECTION 3. Replacing/Restoring neural function: Neurorobotics (Guest lecturer: Prof. Yoky Matsuoka, Comp. Sci. Dept.). See slides. | 21 -- Final Project assignment. See slides. | 23 -- NO CLASS (Thanksgiving) |
| 26 -- SECTION 3. Replacing/Restoring neural function: Computational Modeling of Single Neurons (Guest lecturer: Prof. Adrienne Fairhall, Phys&Biophys.). See slides. | 28 -- SECTION 3. Replacing/Restoring neural function: Computational Modeling of Neuronal Networks (Guest lecturer: Prof. Adrienne Fairhall, Phys&Biophys.). See slides. | 30 -- SECTION 3. Replacing/Restoring neural function: Brain-Computer Interfaces (Guest lecturer: Prof. Eb Fetz, Phys&Biophys.). See slides. |
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DECEMBER
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Monday
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Wednesday
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Friday
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| 3 -- SECTION 3. Replacing/Restoring neural function: Brain-Computer Interfaces (Guest lecturer: Prof. Jeff Ojemann and Dr. Kai Joshua Miller, Neurological Surgery). See slides. | 5 -- SECTION 3. Replacing/Restoring neural function: Artificial Retina. See slides. | 7 -- Last day: Summary; student evaluations |
| 12 -- "EXAM" = Final project discussion (2:30 pm-4:20 pm), must attend! | ||
