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Neural Engineering (BIOEN 498C) homepage

When: Fall 2011, WF 3:30-4:50 P.M.

Where: More Hall Rm 220 except visits to UW Neural Engineering labs.

Handouts: provided as PDFs in this website at least one class day before the lectures.

Assignments: online essays given at the end of each section or sub-section.

Grading: assignments (75% of grade), midterm (25% of grade), and class participation (+ 0.1 points over 4).

Pre-requisites: None specifically.

Textbook: (not mandatory, but it's a good one for ~30% of the material) "Neural Engineering" by Bin He (ed.), Kluwer Academic / Plenum Press. There is one copy at the Engineering Library. If "neuron" and "ion channel" do not mean anything to you, this course might be a little difficult for you - but you are welcome to take it! I recommend starting with Brainfacts, a quick introduction to the nervous system, and moving on to more general textbooks such as "Principles of Neural Science" by Kandel/Schwartz/Jessell (Fourth ed.).

Important note for disabled individuals: If you would like to request academic accommodations due to a disability, please contact Disabled Student Services, 448 Schmitz, (206) 543-8924 (V/TTY). If you have a letter from Disabled Student Services indicating you have a disability that requires academic accommodations, please present the letter to me so we can discuss the accommodations you might need for the class.

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Broad description: This course introduces students to the broad field of Neural Engineering. The course is approximately divided in four sections: 1) Technologies for monitoring neural activity in vivo (whole brain, from human to small animals) and in vitro (from slices to dissociated cells); discussion of challenges associated with device portability, accessibility of stimulation site, and stimulation scale; wireless EEG, fMRI, microfabricated electrode arrays (MEAs), patch clamp electrophysiological recordings; 2) Devices for replacing or restoring neural function: implantable electrodes, brain-computer interfaces (BCI), cochlear implants, artificial retina, artificial nose; 3) Devices for in-vitro neuroscience: neuronal micropatterns, microfluidic systems, iontophoresis, patch clamp chips; 4) Computational and imaging approaches: The BrainBow project, the UW Human Brain project.

Tentative Calendar (check later, it may change!):

SEPTEMBER
Tuesday (lab)	Wednesday	Friday
	28 -- First day: Course basics; Syllabus; Flash Introduction to the Nervous System: Anatomy; The Neuron; See slides in PDF (or in PPT) and "BrainFacts"	30 -- Flash Introduction to the Nervous System (cont.): Electrical Excitability; Microelectrode arrays, patch clamp technique. See slides in PDF (or in PPT) and "BrainFacts"

OCTOBER
Homeworks	Wednesday	Friday

Homework1.PDF	5 -- SECTION 1. Monitoring neural activity: Neural stimulation (general principles); implantable microelectrodes. See slides in PDF or in PPT.	7 -- SECTION 1. Monitoring neural activity: Wireless communication devices for neural recording and stimulation (Visit to Prof. Brian Otis lab, EE). See slides in PDF or in PPT and Otis lab's website.
	12 -- SECTION 1. Monitoring neural activity: EEG. Visit to Dr. John Oakley's lab (Neurology); EEG of a volunteer doing cognitive tasks. See slides in PDF or in PPT.	14 -- SECTION 1. Monitoring neural activity. Brain imaging; fMRI. See slides in PDF or in PPT.
Homework2.PDF	19 -- SECTION 1. Monitoring neural activity. Brain-Computer Interfaces in monkeys. See slides in PDF (only supplement in PPT).	21 -- SECTION 1. Monitoring neural activity: Implantable Brain-Computer Interfaces; the UTAH array. See slides in PDF or in PPT.
	26-- SECTION 1. Monitoring neural activity: Implantable Brain-Computer Interfaces; ECoG. See slides in PDF or in PPT.	28 -- SECTION 1. Monitoring neural activity: Wearable brain-Computer Interfaces. See slides in PDF or in PPT.

NOVEMBER
Tuesday (lab)	Wednesday	Friday
	2 -- SECTION 2. Replacing/Restoring/Enhancing neural function. Cochlear Implants. (Guest lecturer: Dr. Jay Rubinstein, BioE). See slides. A clinical case (UWTV video).	4 -- SECTION 2. Replacing/Restoring/Enhancing neural function. Ocular prostheses. See slides.
Homework3.PDF	9 -- MIDTERM	11 -- NO CLASS
	16 -- SECTION 2. Replacing/Restoring/Enhancing neural function. Radiation therapy. See slides.	18 -- SECTION 2. Replacing/Restoring/Enhancing neural function. Ultrasound for healing nerves, drug delivery and pain treatment (Guest lecturer: Prof. Pierre Mourad, Dept. of Neurological Surgery). See slides.
	23 -- SECTION 2. Replacing/Restoring/Enhancing neural function. (Visit to Prof. Tom Daniel lab, UW Biology).	25 -- NO CLASS (Thanksgiving)
	30 -- SECTION 2. Replacing/Restoring/Enhancing neural function.

DECEMBER
Tuesday (lab)	Wednesday	Friday
		2-- SECTION 2. Replacing/Restoring/Enhancing neural function. Neural Prostheses for locomotion and hand grasp. (Guest lecturer: Prof. Howard Chizeck, EE dept.). See slides.
	7-- SECTION 3. In-vitro systems for molecular/cellular neuroscience. State-of-the art of neuronal cell culture technology; See slides.	9-- SECTION 3. In-vitro systems for molecular/cellular neuroscience. Slices on a chip; patch clamp chips; iontophoresis See slides.

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