Neural Engineering (BIOEN 498C) homepage


When: Fall 2009, WF 3:30-4:50 P.M. 

Where: HST T473 except visits to UW Neural Engineering labs.

Handouts: provided as PDFs in this website at least one class day before the lectures.

Assignments: online quizzes/essays given at the end of each section or sub-section.

Grading: three assignments (0-4 points; weights: 0.25, 0.5 and 1) and class participation (+ 0.1 points).

Pre-requisites: None specifically.

Textbook: (not mandatory, but it's a good one for ~30% of the material) "Neural Engineering" by Bin He (ed.), Kluwer Academic / Plenum Press. There is one copy at the Engineering Library. If "neuron" and "ion channel" do not mean anything to you, this course might be a little difficult for you - but you are welcome to take it! I recommend starting with Brainfacts, a quick introduction to the nervous system, and moving on to more general textbooks such as "Principles of Neural Science" by Kandel/Schwartz/Jessell (Fourth ed.).


Important note for disabled individuals: If you would like to request academic accommodations due to a disability, please contact Disabled Student Services, 448 Schmitz, (206) 543-8924 (V/TTY). If you have a letter from Disabled Student Services indicating you have a disability that requires academic accommodations, please present the letter to me so we can discuss the accommodations you might need for the class.


Broad description: This course introduces students to the broad field of Neural Engineering. The course is approximately divided in four sections: 1) Technologies for monitoring neural activity in vivo (whole brain, from human to small animals) and in vitro (from slices to dissociated cells); discussion of challenges associated with device portability, accessibility of stimulation site, and stimulation scale; wireless EEG, fMRI, microfabricated electrode arrays (MEAs), patch clamp electrophysiological recordings; 2) Devices for replacing or restoring neural function: implantable electrodes, brain-computer interfaces (BCI), cochlear implants, artificial retina, artificial nose; 3) Devices for in-vitro neuroscience: neuronal micropatterns, microfluidic systems, iontophoresis, patch clamp chips;  4) Computational and imaging approaches: The BrainBow project, the UW Human Brain project.

Tentative Calendar (check later, it may change!):

SEPTEMBER

Tuesday (lab)

Wednesday

Friday

 

30 -- First day: Course basics; Syllabus; Flash Introduction to the Nervous System: Anatomy; The Neuron; See slides in PDF (or in PPT) and "BrainFacts"

 

OCTOBER

Tuesday (lab)

Wednesday

Friday

 

2 -- Flash Introduction to the Nervous System (cont.): Electrical Excitability; Microelectrode arrays, patch clamp technique. See slides in PDF (or in PPT) and "BrainFacts"

 

7 -- SECTION 1. Monitoring neural activity: Neural stimulation (general principles); implantable microelectrodes. See slides in PDF or in PPT.

9 -- SECTION 1. Monitoring neural activity: Wireless communication devices for neural recording and stimulation (Visit to Prof. Brian Otis lab, EE). See slides in PDF or in PPT and Otis lab's website.

 13 -- Neuron-on-a-chip LAB (tentative)

 

14 -- SECTION 1. Monitoring neural activity: EEG. Visit to Dr. John Oakley's lab (Neurology); EEG of a volunteer doing cognitive tasks. See slides in PDF or in PPT.

16 -- SECTION 1. Monitoring neural activity. Brain imaging; fMRI. See slides in PDF or in PPT.

 20 -- Neuron-on-a-chip LAB

21 -- SECTION 1. Monitoring neural activity. Brain-Computer Interfaces in monkeys. See slides in PDF (only supplement in PPT).

23 -- SECTION 1. Monitoring neural activity: Implantable Brain-Computer Interfaces; the UTAH array. See slides in PDF or in PPT.

27 -- Neuron-on-a-chip LAB

28-- SECTION 1. Monitoring neural activity: Implantable Brain-Computer Interfaces; ECoG. See slides in PDF or in PPT.

30 -- SECTION 1. Monitoring neural activity: Wearable brain-Computer Interfaces. See slides in PDF or in PPT.

 

NOVEMBER

Tuesday (lab)

Wednesday

Friday

4 -- SECTION 2. Replacing/Restoring neural function. Cochlear Implants. See slides.

6 -- SECTION 2. Replacing/Restoring neural function. Retinal prosthesis. See slides.

11 -- NO CLASS (Veterans' Day)

13 -- SECTION 2. Replacing/Restoring neural function. Ultrasound for healing nerves, drug delivery and pain treatment (Guest lecturer: Prof. Pierre Mourad, Dept. of Neurological Surgery). See slides.

18-- SECTION 2. Replacing/Restoring neural function. Neural Prostheses for locomotion and hand grasp (Guest lecturer: Prof. Howard Chizeck, EE dept.). See slides.

21 -- -- SECTION 2. Replacing/Restoring neural function. Neurorobotics. See slides.

24 -- Replacing/Restoring neural function. Cochlear Implants LAB (Guest lecturer: Dr. Jay Rubinstein, BioE). See slides. A clinical case (UWTV video).

25 --SECTION 2. Replacing/Restoring neural function. Radiation therapy. See slides.

27 -- NO CLASS (Thanksgiving)

 

DECEMBER

Tuesday (lab)

Wednesday

Friday

2-- SECTION 3. In-vitro systems for molecular/cellular neuroscience. State-of-the art of neuronal cell culture technology; See slides.

4 -- SECTION 3. In-vitro systems for molecular/cellular neuroscience. Slices on a chip; patch clamp chips; iontophoresis. See slides.  Class Summary.

9 -- SECTION 4. Imaging and computational approaches. The Brain Atlas; BrainBow Project. See slides.

11 -- SECTION 4. Imaging and computational approaches. The UW Human BrainProject. See slides.