Handouts

Summary and schedule

Discussion papers (presenter):

October 2 (Asbury), Cimini 2004 Curr Biol.pdf

October 9 (Santana), Yeromin 2006 Nature.pdf [optional background reading, Parekh 2005 Physiol Rev.pdf]

October 16 (Williams), Ross 2006 Nat Cell Biol.pdf

October 23 (Myung), Cui 2004 J Neuro.pdf

October 30 (Cafaro), Jia 2006 Nat Neuro.pdf

November 6 (Azevedo), Luik 2006 J Cell Biol.pdf

November 13 (Myung),

November 20 (Williams),

November 27 (Azevedo), Morita 2004 Curr Biol.pdf

December 4 (Cafaro), Xue 2005 Circulation.pdf

Other suggested papers and topics

PBIO 558, Spring 2007
Concepts and Mechanisms in Mitosis

Instructor: Chip Asbury, Linda Wordeman
Email: casbury@u.washington.edu; worde@u.washington.edu

Office: Chip, H-424a (moving soon to J-215/J-217)
Telephone: Chip, 543-7808; Linda, 543-4135

Meeting Times and Locations
(Insert section information here.)

Course description

Goals:  Our primary goal is to hone our skills in critical thinking and group scientific discussion.  Our secondary goal is to learn about new developments in two specific areas of molecular biophysics (topics this year are excitation-contraction coupling and molecular motors / mitosis ).

Evaluation:  Final grades will be given on the basis of student participation (quantity and quality of questions, comments, and/or suggestions) in weekly discussions and their presentations.

Summary of activities:  One or two students will be chosen to lead each session.  Session leaders will select a paper for discussion and obtain instructor approval for this selection at least one week prior to the actual discussion.  The selected paper will then be distributed by posting on the course website.  All participants are expected to read the paper beforehand and to come prepared for discussion and critical evaluation of the work (see Summary and schedule, "How critical should participants be...?").  Session leaders will prepare a powerpoint presentation (1) summarizing the major conclusion of their chosen paper, (2) briefly explaining why it is significant, and (3) displaying the primary evidence that supposedly supports the conclusion (see tips in Summary and schedule).  During class, the session leaders will lead an informal group discussion of the paper.  The primary goal of this discussion is to facilitate evaluation of the work, with particular emphasis on whether the data support the claims made by the authors.  Presenters are expected to choose papers that, in their opinion, represent solid scientific work.  However, it is quite possible that other discussants will not come to the same conclusion.  It is more important to have a critical discussion than to come to a consensus.


Announcements
October 26 2006, 3:49 PM
Apologies

I'll try to be better about posting PDF files as soon as I get them.  Thanks everyone for distributing the files even when I forget!    -Chip


September 19 2006, 1:05 PM
Our first meeting

Chip will be the presenter for our first meeting on October 2 (paper to be chosen).  He will attempt to provide a model for all others to follow!


Images
EC coupling
EC coupling
Molecular Motors
Molecular Motors
Jiff (PBIO 525 mascot)
Jiff (PBIO 525 mascot)