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Click here for PDF copy of syllabus

WEEK 1:   Introduction

WEEK 2:   Dynamic instability of microtubules & the GTP cap hypothesis  (Leigh Ann, Andrew F, Andy P)

WEEK 3:  Discovery of spindle motors  (Megan W, Prerana R, Tessie Ng)

WEEK 4:  Two differing views -- polymer driven vs. ‘muscle-like' mitosis  (Josh B, David W, Andrew F)

WEEK 5:  ‘Flux' -- where are tubulin subunits being added and removed?  (Megan W, Josh B, Sarah D)

WEEK 6:  Assembly is eerily robust – more ways than one to build a spindle  (Michelle S, Sarah D, David W)

WEEK 7:  Kinetochore movements – ‘directional instability', tensiometer model  (Megan W, Michelle S, Sarah D)

WEEK 8:  More micromanipulation – balance of forces in the spindle  (Kathleen R, Jason S, David W)

WEEK 9:  The spindle checkpoint -- attachment, tension, and error correction  (Michelle S, Josh B, Andy P)

WEEK 10:  Ultrastructure of the kinetochore-microtubule interface  (Dan G, Andrew F, Andy P)

PBIO 558, Spring 2007
Concepts and Mechanisms in Mitosis

Instructor: Linda Wordeman, Chip Asbury

Office: Chip, H-424a (moving soon to J-215/J-217)
Telephone: Linda, 543-4135; Chip, 543-7808

Meeting Times and Locations

Mon 9:30 - 11:30 AM, room T474A

Brief course description

In this 10-week (2 credit) mini-course, we will examine how the mitotic spindle organizes and separates duplicated chromosomes during cell division.  The course begins with a brief overview of spindle components and key mechanistic concepts.  Students then choose specific areas for discussion, focusing on recent and/or classic papers from the primary literature.

The main purpose of the course is to review our current understanding of the mechanisms underlying chromosome organization and movement during cell division.  The secondary goal is to provide experience for the students in reading, evaluating, and presenting published results from the literature.  Most of the course will involve presentations and discussion by the students.

March 21 2007, 2:26 PM

Some students interested in taking the class have a time conflict.  On the first day, we will discuss the possibility of meeting ~1 hr later than our scheduled time.  If this is agreeable to everyone, we may change the official meeting time (which could also involve a room change).

Mitosis cartoons
Mitosis cartoons
Real spindles
Real spindles