General Course Information

Goal | Expectations | Grading | Assignments | Texts | Overall Schedule | Citing Resources | Readings | Speakers

Welcome Class of 2011!

Course Goal

It is the hope of the instructors that by the end of this course, you will have grasped some of the building blocks necessary to ensure that your patients receive the right dose of any given drug. To ensure the right dose, you will need to:
  • locate treatments of choice
    (Drug Information Resources component;section leads: Dr. Birchfield, Ms. Jankowski),
  • determine usual drug efficacy and toxicity (read primary literature and understand the methods by which the data were obtained)
    (Research Methods component; section lead: Dr. Sullivan), and
  • calculate patient-specific doses
    (Pharmacy Calculations component; section lead: Dr. O'Sullivan)
Course Expectations
The instructors of this course expect you to:
  • Attend all drug information and research methods lectures and complete all assignments on time in order to maximize your learning in this class.
  • Locate and read all required readings. A list of these readings can be found below in the section titled "Journal articles you will read for this class." You are welcome to begin locating them prior to the start of class.
  • Read all required material prior to the class session in which that material will be discussed and come to class with any lecture materials printed or electronically available.
  • Demonstrate technical writing skills consistent with the ability of students obtaining a doctoral degree.
  • Do all of your own writing. Plagiarism is a form of academic dishonesty and grounds for dismissal. You will cite resources you use in your writing, but you are expected to not plagiarize the work of others. There is available an excellent outline of academic dishonesty that you should read before you start writing for this class.
  • Be comfortable with use of the following computer technology:
    • regularly reading email and responding when appropriate
    • pulling attachments off of email
    • accessing and printing documents from the web
    • accessing and printing Adobe Acrobat files (Free Download)

Grading

Calculations quizzes
10%
Calculation exam A
10%
Calculation exam B
10%
Drug information resource assignments and in-class quizzes
15%
Drug information paper, including rough drafts
25%
Examination (research methods material only)
30%

 

Assignment Links

  • You will write a drug information paper, which will assess your learning of the drug information sources and research methods portion of this class. The first step in writing your paper will be to come up with a question to answer. A good drug information paper question will ask about some aspect of a specific drug or drug class used for a specific condition. In your drug information question, you need to specify the drug or drug class, and the medical condition for which it is to be used. An example of a reasonable drug information paper question is, "How effective is cranberry juice for preventing urinary tract infections?" You will be doing two drug information resource assignments to help you prepare for writing this paper as well as become more familiar with tertiary and secondary drug information resources (for which your knowledge will be assessed in-class using the TurningPoint Response Cards..
  • You will be taking calculations quizzes and exams to test your understanding of how to perform pharmacy calculations.
  • Your understanding of the material in the research methods part of this course will be tested during the final examination.

Texts

Required texts (all available at the University Book Store south campus branch and via Amazon.com or BarnesandNoble.com):

  • Malone PM, Kier KL, Stanovich JE. Drug information: a guide for pharmacists. 3rd ed. New York (NY): McGraw Hill Medical Division, 2006.
  • O'Sullivan TA. Understanding pharmacy calculations. Washington DC: American Pharmaceutical Association, 2002. ISBN: 1-58212-033-1.
  • Hulley SB, Cummings SR, Browner WS, Grady D, Hearst N, Newman TB. Designing clinical research: an epidemiologic approach. 3rd ed. Philadelphia: Lippincott, Williams, & Wilkins, 2006.

    Required device (available at the University Book Store)

  • TurningPoint ResponseCardRF. Thomson. Available at the University Bookstore South Campus and Main Branches. You will need to register the card ID with Cher Espina-Nguyen in the student services office.

Other reading:

Course Schedule

The class will meet on M, W, and F from 11:30-12:20 in room T-747. On 9/28, 10/1, and 10/3, 1/3 the class will meet in T-747, 1/3 in or near the PCLC, and 1/3 in the Health Sciences Library (HSL) computer classroom.

Week Mondays
Wednesdays Fridays
1

9/26/07
Introduction to locating health information resources

Drs. O'Sullivan, Birchfield

Introduction to HSL services
Ms. Jankowski

Reading: DI text p 29-37, 39-59.

 

9/28/07
Electronic tertiary resources
Ms. Jankowski: HSL, Classroom C

Print tertiary resources
Dr. Birchfield, T-488

Reading: DI text p 61-101

Pharmacy calculations: Lesson 2.
Bring your calculator to class.

Dr. O'Sullivan, T-747

2

10/1/07
Electronic tertiary resources
Ms. Jankowski: HSL, Classroom B

Print tertiary resources
Dr. Birchfield, T-488
Reading: DI text: p 61-101

Pharmacy calculations: Lesson 2.
Bring your calculator to class.

Dr. O'Sullivan,
T-747

10/3/07
Electronic tertiary resources
Ms. Jankowski: HSL, Classroom B

Print tertiary resources
Dr. Birchfield, T-488
Reading: DI text p 61-101

Pharmacy calculations: Lesson 2.
Bring your calculator to class.

Dr. O'Sullivan,
T-747

10/5/07
Technical writing.
Dr. Birchfield

Reading: DI text p 375-389

finish calculations quiz #1 by today

3

10/8/07
Tertiary information resources for PDAs
Mr. Westergard

 

 


10/10/07
Secondary resources
Ms. Jankowski
Tertiary resources assignment due

10/12/07
Pharmacy calculations: Lesson 3.
Bring your calculator to class.
Dr. O'Sullivan

finish calculations quiz #2 by today

4

10/15/07
Using PubMed effectively
Leilani St Anna

Rough draft of DI paper introduction due.

10/17/07
An introduction to the principles of evidence-based medicine
Dr. Sullivan

Readings required; see below

.


10/19/07
Pharmacy calculations: Lesson 4.
Bring your calculator to class
Dr. O'Sullivan

finish calculations quiz #3 by today


5

10/22/07
Finding information using commercial search engines
Dr. Birchfield

Reading: DI text p 103-138

Secondary resources assignment due

10/24/07
Summarizing a study

Dr. O'Sullivan

Click here for a copy of the slides

please pull, print, and bring the HOPE study (print the pdf version)

10/26/07
TPN calculations
Dr. O'Sullivan

finish calculations quiz #4 by today


6

10/29/07
Calculations Exam A
(covers material from lessons 1-4)

Paragraph of study for DI paper due

10/31/07
Calculations Exam B: TPN Calculations Exam

Career Day today - make sure you stop by the South Campus Center and network!

11/2/07
The drug, device, biologic, and nutraceuticals development process and the FDA
Dr. Hazlet

Readings required; see below

7

11/5/07
Introduction to research methods
Dr. Sullivan

Readings required; see below

11/7/07
Clinical pharmacokinetic studies
Dr. Shen

Readings required; see below

11/9/07
Clinical pharmacokinetic studies II
Dr. Thummel

Readings required; see below

8

11/12/07
 HOLIDAY


11/14/07
Observational studies
Dr. Boudreau

Readings required; see below

11/16/07
Post-marketing surveillance
Dr. Gardner

Readings required; see below

9

11/19/07
Experimental studies
Dr. Blough

Readings required; see below

Drug Information Paper Due

11/21/07
Interpreting results of RCTs and observational studies
Dr. Johnson

Readings required; see below

11/23/07
HOLIDAY

10

11/26/07
Economic evaluations
Dr. Garrison
For color pdf handout of this lecture, click here

Readings required; see below

11/28/07
Use of clinical evidence and indirect comparisons
color slides (12 pages)
B/W slides (8 pages)
slides w/notes (16 pages)
Mr. Watkins

11/30/07
Privacy and informed consent
Dr. Devine
color slides

Readings required; see below.

11

12/3/07
Meta-analysis
Dr. Veenstra

Readings required; see below.


12/5/07
Qualitative research and service learning
Dr. Dawson


12/7/07 
Research Methods Examination 
  • This class does not have a scheduled final exam.

Format for References and Citations

  • Information about citing methods and reference format has been consolidated into a single page.
  • When citing electronic sources, please be sure to turn off Microsoft Word's hotlink auto-format function if you find that it turns your pasted web addresses into hotlinks (i.e., turns them blue and underlines them).

Readings for this class

To familiarize you with various types of medical literature, you will be asked to read several medical journal articles, as well as readings from the required textbook "Designing Clinical Research." All readings are listed below, along with the dates you will need to have completed these readings. For most articles you will need to go to the electronic journals web page for the library. You will find it easiest to print the Adobe Acrobat (PDF) version. All readings are available through PubMed as PDF or computer readable files. Search via author names, or for the JAMA articles, by issue.

Reading list

For lecture, read: in Designing Clinical Research: and read the folllowing:
11/2/07
The drug, device, biologic, and nutraceuticals development process and the FDA
Dr. Hazlet

Drug information: a guide for pharmacists. Chapter 18: Investigational drugs.

Check out the FDA web site: <http://www.fda.gov> and the Centers for Biologic or Drug Evaluation and Review.

11/5/07
Introduction to research methods
Dr. Sullivan
Chapter 1, 2  
11/7/07
Clinical pharmacokinetic studies
Dr. Shen

Gibaldi M, Levy G. Pharmacokinetics in clinical practice 1: concepts, JAMA 1976;235(17):1864-7

Gibaldi M, Levy G. Pharmacokinetics in clinical practice 2: applications, JAMA 1976;235(18):1987-92

These readings have been placed in a single file.

11/9/07
Clinical pharmacokinetics II
Dr. Thummel
  Majumdar AK, McCrea JB, Panebianco DL, Hesney M, et al. Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe. Clin Pharmacol Ther 2003; 74(2):150-156.
11/14/07
Observational studies
Dr. Boudreau
Chapters 7, 8, 9
 
11/16/07
Post-marketing surveillance
Dr. Gardner
 

Drug information: a guide for pharmacists. Chapter 7, p 237

Mosholder AD, Parner CA. Postmarketing surveillance of suicidal adverse evernts with pediatric use of antidepressants. J Child Adolesc Psychopharmacol 2006;16:33-6.

11/19/07
Experimental studies
Dr. Blough

Chapter 5, 6, 10
 
11/21/07
Interpreting results of RCTs and observational studies
Dr. Johnson

Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effect. BMJ 1995;310:452-454.

11/26/07
Economic evaluations
Dr. Garrison
 

Drug information: a guide for pharmacists. Chapter 8

Mark DB, Hlatky MA, Califf RM, Naylor CD, Lee KL, Armstrong PW, Barbash G, White H, Simoons ML, Nelson CL, Clapp-Channing N, Knight JD, Harrell FE, Simes J, Topol EJ. Cost effectiveness of thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute myocardial infarction. N Engl J Med 1995;332:1418-24.

11/28/07
Use of clinical evidence and indirect comparisons
Mr. Watkins
 

 

11/30/07
Privacy and informed consent
Dr. Devine
Chapter 14

Please read over the University of Washington Human Subjects Division, Frequently Asked Questions.

12/3/07
Meta-analysis
Dr. Veenstra
 Chapter 13

Morrison A, Wertheimer, AI. Evaluation of studies investigating the effectiveness of pharmacists' clinical services. Am J Health Syst Pharm 2001;58(7):569-77

 

Speakers

Mary Birchfield, PharmD, RM(NRM), MT(ASCP), Clinical Assistant Professor, School of Pharmacy, University of Washington.

David Blough, PhD. Research Associate Professor, Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington.

Denise Boudreau, RPh, PhD. Investigator, Group Health Cooperative Center for Health Studies. Affiliate Assistant Professor, Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington.

Beth Devine, PharmD, MBA. Research Associate Professor, Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington

Jacqueline Gardner, MPH, PhD. Professor, Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington.

Louis Garrison, PhD, Professor, Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington

Thomas K. Hazlet, PharmD, DPH. Associate Professor, Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington.

Terry Jankowski, MLS, AHIP, Head, Information and Education Services, Health Sciences Libraries, Liaison to Schools of Pharmacy, Dentistry, and Rehabilitation Medicine, University of Washington.

Eric Johnson, PhD. Affiliate Assistant Professor, School of Pharmacy, University of Washington

Teresa O'Sullivan, BSPharm, PharmD, BCPS. Lecturer and Director, Experiential Education, School of Pharmacy, University of Washington.

Danny Shen, PhD. Chair, Department of Pharmacy, School of Pharmacy, University of Washington

Leilani St. Anna, MLIS, AHIP, Information Management Librarian, Health Sciences Libraries, Liaison to School of Medicine, Family Medicine, Pediatrics, WWAMI, and UWPN, University of Washington

Sean Sullivan, BSPharm, PhD. Professor, Department of Pharmarcy; Director, Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington.

Ken Thummel, PhD. Professor and Associate Dean for Research, Department of Pharmaceutics, School of Pharmacy, University of Washington.

David L. Veenstra, PharmD, PhD, Affiliate Assistant Professor, Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington.

John Watkins, BSPharm, MPH, BCPS, Pharmacy Manager, Formulary Development, Premera Blud Cross; Affiliate Associate Professor, Department of Pharmaceutics, School of Pharmacy, Universtiy of Washington.

Charles Westergard, BSPharm, MBA. Vice-President of Product Development, HealthProLink, Inc.

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Last updated:4 December 2007