It is the hope of
the instructors that by the end of this course, you will have grasped
some of the building blocks necessary to ensure that your patients receive
the right dose of any given drug. To ensure the right dose, you will need
to:
-
-
determine
usual drug efficacy and toxicity (read primary literature and
understand the methods by which the data were obtained)
(Research Methods component; section
lead: Dr. Sullivan),
and
-
calculate
patient-specific doses
(Pharmacy Calculations component; section
lead: Dr. O'Sullivan)
The instructors
of this course expect you to:
-
Attend all drug information and research methods lectures
and complete all assignments on time in order to maximize
your learning in this class.
- Locate and read all
required readings.
A list of these readings can be found below in the section
titled
"Journal articles you will read for this class." You are welcome
to begin locating them prior to the start of class.
-
Read all required material prior to the class session in
which that material will be discussed and come to class with
any lecture materials printed or electronically available.
-
Demonstrate
technical writing skills consistent with the ability of
students obtaining a doctoral degree.
- Do all of your
own writing.
Plagiarism is a form of academic dishonesty and grounds for dismissal.
You will cite resources you use in your writing, but you are
expected
to not
plagiarize
the
work
of others.
There
is available
an excellent
outline
of academic dishonesty that you should read before
you start writing for this class.
-
Be
comfortable with use of the following computer technology:
- regularly reading email and responding when appropriate
-
pulling attachments off of email
-
accessing and printing documents from the web
-
Grading
| Calculations
quizzes |
10%
|
| Calculation
exam A |
10%
|
| Calculation
exam B |
10%
|
| Drug
information resource
assignments and in-class quizzes |
15% |
| Drug
information paper, including rough drafts |
25%
|
|
Examination (research methods material only) |
30%
|
-
You will
write a drug information
paper,
which will assess your learning of the drug information sources
and research methods portion of
this class. The first step in writing your paper will be to come
up with a question to answer. A good drug information paper question
will ask about some aspect of a specific
drug or drug class used for a specific condition. In your
drug information question, you need to specify the
drug or drug class, and the medical condition for
which it is to be used. An example of a reasonable drug information
paper question is, "How effective is cranberry juice for preventing
urinary tract infections?" You
will be doing two
drug information resource assignments to help
you prepare for writing this paper
as well as become more familiar with tertiary and secondary drug
information resources (for which your knowledge will be assessed
in-class using the TurningPoint Response Cards..
-
-
Your
understanding of the material in the research
methods part of this course will be tested
during the final
examination.
Required texts
(all available at the University
Book Store south campus branch and via Amazon.com or BarnesandNoble.com):
Other reading:
Course
Schedule
The
class will meet on M, W, and F from 11:30-12:20 in room T-747. On
9/28, 10/1, and 10/3, 1/3 the class will meet in T-747, 1/3 in or near
the PCLC, and 1/3 in the Health Sciences Library (HSL)
computer classroom.
| Week |
Mondays
|
Wednesdays |
Fridays |
| 1 |
|
9/26/07
Introduction to locating health information resources
Drs. O'Sullivan, Birchfield
Introduction
to HSL services
Ms. Jankowski
Reading: DI
text p 29-37, 39-59.
|
9/28/07
Electronic tertiary resources
Ms. Jankowski:
HSL,
Classroom C
Print tertiary
resources
Dr. Birchfield, T-488
Reading: DI text p 61-101
Pharmacy calculations:
Lesson 2.
Bring your calculator to class.
Dr. O'Sullivan, T-747
|
| 2 |
10/1/07
Electronic tertiary resources
Ms. Jankowski: HSL,
Classroom B
Print tertiary
resources
Dr. Birchfield, T-488
Reading: DI
text: p 61-101
Pharmacy
calculations: Lesson 2.
Bring your calculator to class.
Dr. O'Sullivan, T-747
|
10/3/07
Electronic tertiary resources
Ms. Jankowski: HSL,
Classroom B
Print tertiary
resources
Dr. Birchfield, T-488
Reading: DI
text p 61-101
Pharmacy
calculations: Lesson 2.
Bring your calculator to class.
Dr. O'Sullivan, T-747
|
10/5/07
Technical
writing.
Dr. Birchfield
Reading: DI
text
p 375-389
finish calculations quiz #1 by today
|
| 3 |
10/8/07
Tertiary information resources for PDAs
Mr. Westergard
|
10/10/07
Secondary
resources
Ms. Jankowski
Tertiary resources assignment due
|
10/12/07
Pharmacy calculations: Lesson 3.
Bring your
calculator to class.
Dr. O'Sullivan
finish
calculations quiz #2 by today
|
| 4 |
10/15/07
Using PubMed effectively
Leilani St Anna
Rough
draft of DI paper introduction due.
|
10/17/07
An introduction to the principles of evidence-based medicine
Dr. Sullivan
Readings required;
see below
.
|
10/19/07
Pharmacy
calculations: Lesson 4.
Bring your calculator
to class
Dr. O'Sullivan
finish
calculations quiz #3 by today
|
| 5 |
10/22/07
Finding information using commercial search engines
Dr. Birchfield
Reading: DI
text p
103-138
Secondary
resources assignment due
|
10/24/07
Summarizing a study
Dr. O'Sullivan
Click
here for a copy
of the slides
please pull,
print, and bring the HOPE study (print the pdf version)
|
10/26/07
TPN calculations
Dr. O'Sullivan
finish
calculations quiz #4 by today
|
| 6 |
10/29/07
Calculations Exam A
(covers material from lessons 1-4)
Paragraph
of study for DI paper due
|
10/31/07
Calculations Exam B: TPN Calculations Exam
Career Day today - make sure you
stop by the South Campus Center and network!
|
11/2/07
The
drug, device, biologic, and nutraceuticals development process
and the FDA
Dr. Hazlet
Readings required;
see below
|
| 7 |
11/5/07
Introduction to research methods
Dr. Sullivan
Readings required;
see below
|
11/7/07
Clinical pharmacokinetic studies
Dr. Shen
Readings required;
see below
|
11/9/07
Clinical pharmacokinetic studies II
Dr. Thummel
Readings required;
see below
|
| 8 |
11/12/07
HOLIDAY
|
11/14/07
Observational studies
Dr. Boudreau
Readings required;
see below
|
11/16/07
Post-marketing surveillance
Dr. Gardner
Readings required;
see below
|
| 9 |
11/19/07
Experimental studies
Dr. Blough
Readings required;
see below
Drug Information
Paper Due
|
11/21/07
Interpreting
results of RCTs and observational studies
Dr. Johnson
Readings required;
see below
|
11/23/07
HOLIDAY
|
| 10 |
11/26/07
Economic
evaluations
Dr. Garrison
For color pdf handout of this lecture, click here
Readings required;
see below
|
11/28/07
Use of clinical evidence and indirect comparisons
color slides (12 pages)
B/W slides (8 pages)
slides w/notes (16 pages)
Mr. Watkins
|
11/30/07
Privacy and informed consent
Dr. Devine
color slides
Readings required;
see below.
|
| 11 |
12/3/07
Meta-analysis
Dr. Veenstra
Readings required;
see below.
|
12/5/07
Qualitative research and service learning
Dr. Dawson
|
12/7/07
Research Methods Examination |
- This class does not have
a scheduled final exam.
Format
for References and Citations
- Information
about citing methods and reference format has been consolidated into a single
page.
- When
citing electronic sources, please
be sure to turn off Microsoft Word's hotlink auto-format function
if you find that
it turns your
pasted web
addresses into hotlinks (i.e., turns them blue and underlines
them).
Readings
for this class
To familiarize
you with various types of medical literature, you will be asked to
read several medical journal articles, as well as
readings from the required textbook "Designing Clinical Research." All
readings are listed below, along with the dates you will need to have
completed these readings. For most articles you will need to go to the
electronic journals web page for the library. You will find it easiest
to print the Adobe Acrobat (PDF) version. All readings are available
through PubMed as PDF or computer readable files. Search via author names,
or for the JAMA articles, by issue.
Reading
list
| For
lecture, read: |
in Designing
Clinical Research: |
and
read the folllowing: |
11/2/07
The drug, device, biologic, and nutraceuticals development process
and the FDA
Dr. Hazlet |
|
Drug
information: a guide for pharmacists. Chapter 18:
Investigational drugs.
Check out the
FDA web site: <http://www.fda.gov> and
the Centers for Biologic or Drug Evaluation and Review. |
11/5/07
Introduction to research methods
Dr. Sullivan |
Chapter
1, 2 |
|
11/7/07
Clinical pharmacokinetic studies
Dr. Shen |
|
Gibaldi M, Levy G. Pharmacokinetics
in clinical practice 1: concepts, JAMA 1976;235(17):1864-7
Gibaldi M, Levy G. Pharmacokinetics
in clinical practice 2: applications, JAMA
1976;235(18):1987-92
These readings have been placed in a single file. |
11/9/07
Clinical pharmacokinetics II
Dr. Thummel
|
|
Majumdar
AK, McCrea JB, Panebianco DL, Hesney M, et al. Effects of aprepitant
on cytochrome P450 3A4 activity using midazolam as a probe. Clin
Pharmacol Ther 2003; 74(2):150-156. |
11/14/07
Observational studies
Dr. Boudreau |
Chapters
7, 8, 9 |
|
11/16/07
Post-marketing surveillance
Dr. Gardner |
|
Drug information:
a guide for pharmacists. Chapter 7, p 237
Mosholder
AD, Parner CA. Postmarketing surveillance of suicidal adverse evernts
with pediatric use of antidepressants. J Child Adolesc Psychopharmacol
2006;16:33-6. |
11/19/07 Experimental
studies
Dr. Blough
|
Chapter 5, 6, 10 |
|
| 11/21/07
Interpreting results of RCTs and observational studies
Dr. Johnson
|
|
Cook
RJ, Sackett DL. The number needed to treat: a clinically useful
measure of treatment effect. BMJ 1995;310:452-454.
|
11/26/07
Economic evaluations
Dr. Garrison |
|
Drug
information: a guide for pharmacists. Chapter 8
Mark DB, Hlatky MA,
Califf RM, Naylor CD, Lee KL, Armstrong PW, Barbash G, White
H, Simoons ML, Nelson CL, Clapp-Channing N, Knight JD, Harrell
FE, Simes J, Topol EJ. Cost effectiveness of thrombolytic therapy
with tissue plasminogen activator as compared with streptokinase
for acute myocardial infarction. N Engl J Med 1995;332:1418-24. |
| 11/28/07
Use of clinical evidence and indirect comparisons
Mr. Watkins
|
|
|
11/30/07
Privacy and informed consent
Dr. Devine |
Chapter 14 |
Please
read over the University of Washington Human Subjects Division,
Frequently
Asked Questions.
|
12/3/07
Meta-analysis
Dr. Veenstra |
Chapter
13 |
Morrison
A, Wertheimer, AI. Evaluation of studies investigating the
effectiveness of pharmacists' clinical services. Am J Health
Syst Pharm 2001;58(7):569-77
|
Speakers
Mary
Birchfield,
PharmD, RM(NRM), MT(ASCP), Clinical Assistant Professor, School of
Pharmacy, University of Washington.
David Blough,
PhD. Research Associate Professor, Pharmaceutical Outcomes Research and
Policy Program, School of Pharmacy, University of Washington.
Denise
Boudreau,
RPh, PhD. Investigator, Group Health Cooperative Center for Health
Studies. Affiliate Assistant Professor, Pharmaceutical Outcomes
Research and Policy Program, School of Pharmacy, University of Washington.
Beth Devine,
PharmD, MBA. Research Associate Professor, Pharmaceutical Outcomes
Research and Policy Program,
School of Pharmacy, University of Washington
Jacqueline
Gardner,
MPH, PhD. Professor, Pharmaceutical Outcomes Research and
Policy Program, School of Pharmacy, University of Washington.
Louis
Garrison,
PhD, Professor, Pharmaceutical Outcomes Research and
Policy Program, School of Pharmacy, University of Washington
Thomas K.
Hazlet,
PharmD, DPH. Associate Professor, Pharmaceutical Outcomes Research
and Policy Program, School of Pharmacy, University of Washington.
Terry Jankowski,
MLS, AHIP, Head, Information and Education Services, Health Sciences
Libraries, Liaison to Schools of Pharmacy, Dentistry, and Rehabilitation
Medicine, University of Washington.
Eric Johnson,
PhD. Affiliate Assistant Professor, School of Pharmacy, University
of Washington
Teresa
O'Sullivan,
BSPharm, PharmD, BCPS. Lecturer and Director, Experiential Education,
School of Pharmacy, University of Washington.
Danny
Shen, PhD. Chair, Department of Pharmacy, School of Pharmacy,
University of Washington
Leilani St.
Anna, MLIS, AHIP, Information Management Librarian, Health
Sciences Libraries, Liaison to School of Medicine, Family Medicine,
Pediatrics, WWAMI, and UWPN, University of Washington
Sean
Sullivan,
BSPharm, PhD. Professor, Department of Pharmarcy; Director, Pharmaceutical
Outcomes Research and Policy Program, School of Pharmacy, University
of Washington.
Ken
Thummel,
PhD. Professor and Associate Dean for Research, Department of
Pharmaceutics, School of Pharmacy, University of Washington.
David
L. Veenstra,
PharmD, PhD, Affiliate Assistant Professor, Pharmaceutical Outcomes
Research and Policy Program, School of Pharmacy, University of Washington.
John
Watkins,
BSPharm, MPH, BCPS, Pharmacy Manager, Formulary Development,
Premera Blud Cross; Affiliate Associate Professor, Department
of Pharmaceutics,
School of
Pharmacy,
Universtiy
of Washington.
Charles
Westergard,
BSPharm, MBA. Vice-President of Product Development, HealthProLink,
Inc.
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University of Washington. All Rights Reserved.
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O'Sullivan
Last updated:4 December 2007

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