Schedule
Lectures: M W 10:30 A.M. - 11:20 A.M. | F 10:30 A.M. - 12:20 P.M.
Room: T-530 | T498
| Week 1 | March 31 | Introduction to the Nervous system and Synaptic Transmission | Bajjalieh | Downloads | |
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| 3/31 & 4/2 | Introduction and overview of drug action | Lecture 1 PDF Lecture 2 PDF |
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| 4/4 | Drugs that modulate receptor action - barbiturates, benzodiazepines
In class discussion of Science 290:13, Nature Neuroscience 3:587, Nature 401:796, Mol. Pharm. 59:442, Nature 451:330 |
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| Week 2 | April 7 | Modulation of Excitability: Ion Channels and GABA Receptors | Catterall | ||
| 4/7 | Local anesthesia and sodium channels
Molecular Basis of Neuropharmacology, Chapter 3, review pp. 33-44, read pp. 44-57. |
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| 4/9 | General anesthesia, GABA receptors, and other anesthetic targets
Molecular Basis of Neuropharmacology, Chapter 7, pp. 154-163; Brenner, Pharmacology, Chapter 25. |
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| 4/11 | Epilepsy and anti-epileptic drugs; inherited epilepsies
Molecular Basis of Neuropharmacology, Chapter 21, pp. 490-502, plus papers to be assigned. |
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| Week 3 | April 14 | Modulation of Neurotransmission by amines and neuropeptides | Phillips | ||
| 4/14 | Neuromodulation. Introduction to the amines.
Molecular Basis of Neuropharmacology pp167-187, 192-199. |
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| 4/16 | Parkinson's Disease. Antidepressants
Molecular Basis of Neuropharmacology pp303-308, 312-319, 338-350. |
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| 4/18 | Psychostimulants, Hallucinogens, Antipyschotics
Molecular Basis of Neuropharmacology pp355-362, 383-395, 398-407; In class discussion of Science 305:217, Neuron 45:11-6, Neuron 48:701-6, Cell Mol Life Sci 63:6-11. |
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| Week 4 | April 21 | Modulation of Neurotransmission by Therapeutic Drugs | Chavkin | ||
| 4/21 | Neuropeptides and Pain mechanisms
readings: pp214-228 (neuropeptides) pp 433-449 (analgesic drug actions) | ||||
| 4/23 | Cyclooxygenase inhibitors in analgesia and stroke
readings: pp 433-449 (analgesic drug actions) | ||||
| 4/25 | Stress and Addiction mechanisms
readings: pp 360-381 (chapter 16: Addiction) In class discussion of Deroche-Gamonet V, Belin D, Piazza PV (2004) Evidence for addiction-like behavior in the rat. Science 305(5686):1014-7. | ||||
| Week 5 | April 28 | Lipids as neurotransmitters | Stella | ||
| 4/28 | Endocannabinoids and lysophosphatidic acid.
Molecular Basis of Neuropharmacology pp365-366, 395-398. | ||||
| 4/30 | Summary class (Faculty) | ||||
| 5/2 | |||||