Current Topics in Pharmacology
12:30 PM, Wednesday, October 13, 1999
Room T-530/530A HSC
Speaker: Dan Gallagher
Topic: Learning your ABC's: The role of Rim Protein in vision
Weng, J., Mata, N.L., Azarian, S.M., Tzekov, R.T., Biorch, D.G., and Travis, G.H. (1999) Insights into the function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in ABCR Knockout Mice. Cell 98:13-23.
Hui S, Molday RS, Nathans J. (1999) Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease. J. Biol. Chem. 274(12):8269-8281.
Illing M, Molday LL, Molday, RS. (1997) The 220kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily. J. Biol. Chem. 272(15):10303-10.
Allikmets R, Singh N, Sun H, Shroyer NF, Hutchinson A, Chidambaram A, Gerrard B, Baird L, Stauffer D, Peiffer A, Rattner A, Smallwood P, Li Y, Anderson KL, Lewis RA, Nathans J, Leppert M, Dean M, Lupski JR. (1997) A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat. Genet. 15(3):236-46
De La Paz MA, Guy VK, Abou-Donia S, Heinis R, Bracken B, Vance JM, Gilbert JR, Gass JD, Haines JL, Pericak-Vance MA. (1999) Analysis of the Stargardt disease gene (ABCR) in age-related macular degeneration. Opthamology 106(8):1531-6.
Zhang K, Kniazeva M, Hutchinson A, Han M, Dean M, Allikmets R. (1999) The ABCR gene in recessive and dominant stargardt diseases: A genetic pathway in macular degeneration. Genomics 60(2):234-7.
Bok D. (1999 ) Photoreceptor "Retinoid Pumps" in Health and Disease. Neuron 23(3) 412-414.
Shroyer NF, Lewis RA, Allikmets R, Singh N, Dean M, Leppert M, Lupski JR. (1999) The rod photoreceptor ATP-binding cassette transporter gene, ABCR, and retinal disease: from monogenic to multifactorial. Vision Res 39(15):2537-44.
1999-2000 Journal Club Schedule