Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 20, 1999
Room T-530/530A HSC

Speaker: Christian Wade
Topic: Prancer's Story: the genetics of narcolepsy


  1. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451.

  2. Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98:365-376.

  3. Mignot E, Wang C, Rattazzi C, Gaiser C, Lovett M, Guilleminault C, Dement WC, Grumet FC (1991) Genetic linkage of automosal recessive canine narcolepsy with a m immunoglobulin heavy-chain switch-like segment. Proc. Natl. Acad. USA 88:3475-3478.

  4. Nishino S and Mignot E (1997) Pharmacological effects of narcolepsy. Prog. Neurobiol. 52:27-78.

  5. Smart D, Jerman JC, Brough SJ, Rushton SL, Murdock PR, Jewitt F, Elshourbagy NA, Ellis CE, Middlemiss DN, Brown F (1999) Characterization of a recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR. Br. Jour. Phcol. 128:1-3.

  1. Faraco J, Lin X, Li R, Hinton L, Lin L, and Mignot E (1999) Genetic studies in narcolepsy, a disorder affecting REM sleep. J. Hered. 90:129-132.

  2. Ostrander EA and Giniger E (1999) Let sleeping dogs lie?. Nat. Genet. 23:3-4.

  3. Siegel JM (1999) Narcolepsy: a key role for hypocretins (orexins). Cell 98:409-412.

1999-2000 Journal Club Schedule

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