Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 20, 1999
Room T-530/530A HSC

Speaker: Christian Wade
Topic: Prancer's Story: the genetics of narcolepsy

Papers:

  1. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451.

  2. Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98:365-376.

  3. Mignot E, Wang C, Rattazzi C, Gaiser C, Lovett M, Guilleminault C, Dement WC, Grumet FC (1991) Genetic linkage of automosal recessive canine narcolepsy with a m immunoglobulin heavy-chain switch-like segment. Proc. Natl. Acad. USA 88:3475-3478.

  4. Nishino S and Mignot E (1997) Pharmacological effects of narcolepsy. Prog. Neurobiol. 52:27-78.

  5. Smart D, Jerman JC, Brough SJ, Rushton SL, Murdock PR, Jewitt F, Elshourbagy NA, Ellis CE, Middlemiss DN, Brown F (1999) Characterization of a recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR. Br. Jour. Phcol. 128:1-3.

Reviews:
  1. Faraco J, Lin X, Li R, Hinton L, Lin L, and Mignot E (1999) Genetic studies in narcolepsy, a disorder affecting REM sleep. J. Hered. 90:129-132.

  2. Ostrander EA and Giniger E (1999) Let sleeping dogs lie?. Nat. Genet. 23:3-4.

  3. Siegel JM (1999) Narcolepsy: a key role for hypocretins (orexins). Cell 98:409-412.


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