Current Topics in Pharmacology
12:30 PM, Wednesday, November 10, 1999
Room T-530/530A HSC
Speaker: Weiru Chang
Topic: SlitThe bifunctional guidance cue for Robo receptor
Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W, Tessier-Lavigne M. (1999) Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. Cell 96:771-784.
Kidd T, Bland KS, Goodman CS. (1999) Slit is the midline repellent for the robo receptor in Drosophila. Cell 96:785-794.
Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T. (1999) Slit proteins bind Robo receptors and have an evolutionary conserved role in repulsive axon guidance. Cell 96:795-806.
Li HS, Chen JH, Wu W, Fagaly T, Zhou L, Yuan W, Dupuis S, Jiang ZH, Nash W, Gick C, Ornitz DM, Wu JY, Rao Y. (1999) Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 96:807-818.
Nguyen Ba-Charvet KT, Brose K, Marillat V, Kidd T, Goodman CS, Tessier-Lavigne M, Sotelo C, Chedotal A. (1999) Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. Neuron 22:463-473.
Wu W, Wong K, Chen J, Jiang Z, Dupuis S, Wu JY, Rao Y. (1999) Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature 400:331-336.
Bashaw GJ, Goodman CS. (1999) Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion. Cell 97:917-926.
Yuan W, Zhou L, Chen JH, Wu JY, Rao Y, Ornitz DM. (1999) The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev. Biol. 212:290-306.
Zinn K, Sun Q. (1999) Slit branches out: a secreted protein mediates both attractive and repulsive axon guidance. Cell 97:1-4.
Van Vactor D, Flanagan JG. (1999) The middle and the end: slit brings guidance and branching together in axon pathway selection. Neuron 22:649-652.
Guthrie S. (1999) Axon guidance: starting and stopping with slit. Curr. Biol. 9:R432-435.
Seeger MA, Beattie CE. (1999) Attraction versus Repulsion: Modular Receptors Make the Difference in Axon Guidance. Cell 97:821-824.
1999-2000 Journal Club Schedule