Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, November 24, 1999
Room T-530/530A HSC

Speaker: Sara Muchinsky
Topic: The effects of chronic cocaine use in the nucleus accumbens: Fos related antigen (FRA) induction and PKA activation.

References:

  1. Hope B, Nye H, Kelz M, Self D, Iadarola M, Nakabeppu Y, Duman R, and Nestler E. (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13:1235-44.

  2. Nye H, Hope B, Kelz M, Iadarola M, and Nestler E. (1995) Pharmacological studies of the regulation of chronic Fos-related antigen induction by cocaine in the striatum and nucleus accumbens. J. Pharm. Exper. Ther. 275:1671-80.

  3. Hiroi N, Brown J, Haile C, Ye H, Greenberg M, and Nestler E. (1997) FosB mutant mice: loss of chronic cocaine induction of fos-related proteins and heightened sensitivity to cocaines psychomotor and rewarding effects. Proc. Natl. Acad. Sci. USA 94:10397-402.

  4. Kelz M, Chen J, Carlezon W, Whisler K, Gilden L, Beckmann A, Steffen C, Zhang Y, Marotti L, Self D, Tkatch T, Baranauskas G, Surmeier D, Neve R, Duman R, Picciotto M, and Nestler E. (1999) Expression of the transcription factor DfosB in the brain controls sensitivity to cocaine. Nature 401:272-6.

  5. Self D, Genova L, Hope B, Barnhart W, Spencer J, and Nestler E. (1998) Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J. Neurosci. 18(5):1848-59.

  6. Zhang X, Hu X, and White F. (1998) Whole-cell plasticity in cocaine withdrawl: reduced sodium currents in nucleus accumbens neurons. J. Neurosci. 18(1):488-98.

  7. White F, Hu X, and Zhang X. (1997) Neuroadaptations in nucleus accumbens nuerons resulting from repeated cocaine administration. Adv. Pharm. 42:1006-9.

  8. Carlezon W, Thome J, Olson V, Lane-Ladd S, Brodkin E, Hiroi N, Duman R, Neve R and Nestler E. (1998) Regulation of cocaine reward by CREB. Science 282:2272-4.

Review:
  1. Nestler E, and Aghajanian G. (1997) Molecular and cellular basis of addiction. Science 278:58-63.


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