Current Topics in Pharmacology
12:30 PM, Wednesday, December 8, 1999
Room T-530/530A HSC
Speaker: Jeff Miller
Topic: Building a better signaling pathway: Regulation of MAPK signaling by scaffold proteins
Scaffold proteins in S. cervisiae
Mahanty, S.K., Wang, Y., Farley, F.W., and Elion E.A. (1999). Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade. Cell 98, 501-512.
Pryciak, P.M. and Huntress, F.A. (1998). Membrane recruitment of the kinase scaffold protein Ste5 by the Gbg complex underlies activation of the yeast pheromone response pathway. Genes & Dev 12, 2684-2697.
Posas, F., and Saito, H. (1997). Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role for Pbs2 MAPKK. Science 276, 1702-1705.
Choi, K.Y., Satterberg, B., Lyons, D.M., and Elion, E.A. (1994). Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cervisiae. Cell 78, 499-512.
Scaffold proteins in mammalian MAPK pathways
Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., and Yamamoto, K. (1999). JSAP1, a novel Jun-N-Terminal protein kinase-binding protein that functions as a scaffold factor in the JNK signaling pathway. Mol. Cell Biol. 19, 7539-7548.
Yasuda, J., Whitmarsh, A.J., Cavanagh, J., Sharma, M., and Davis, R.J. (1999). The JIP group of mitogen-activated protein kinase scaffold proteins. Mol. Cell Biol. 19, 7245-7524.
Whitmarsh, A.J., Cavanagh, C., Yasuda, J., and Davis, R.J. (1998). A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281, 1671-1674.
Schaeffer, H.J., Catling, A.D., Eblen, S.T., collier, L.S., Krauss, A., and Weber, M.J. (1998). MP1: a MEK binding partner that enhances activation of the MAP kinase cascade. Science 281, 1668-1671.
Dickens, M., Rogers, J.S., Cavanagh, J. Ritiano, Z.X., Halpern, J.R., Greenberg, M.E., Sawyers, C.L., and Davis, R.J. (1997). A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277, 693-696.
Garrington, T.P. and Johnson, G.L. (1999). Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr. Opin. Cell Biol. 11, 211-218.
Schaeffer, H.J. and Weber, M.J. (1999). Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell Biol. 19, 2435-2444.
Whitmarsh, A.L. and Davis, R.J. (1998). Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem. Sci. 23, 481-485.
Pawson, T. and Scott, J.D. (1997). Signaling through scaffold, anchoring and adapter proteins. Science 278, 2075-2080.
1999-2000 Journal Club Schedule