Current Topics in Pharmacology
12:30 PM, Wednesday, January 12, 2000
Room T-530/530A HSC
Speaker: Bill Watt
Topic: Probing the Physical Intimacy of GPCR's Liason with Ras: An Expose of Promiscuity
Luttrell LM, Daaka Y, Della Rocca GJ, Lefkowitz RJ. (1997) G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. J Biol Chem. Dec 12;272(50):31648-56.
Daaka Y, Luttrell LM, Ahn S, Della Rocca GJ, Ferguson SS, Caron MG, Lefkowitz RJ. (1998) Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J Biol Chem. Jan 9;273(2):685-8.
Lin FT, Daaka Y, Lefkowitz RJ. (1998) beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J Biol Chem. Nov 27;273(48):31640-3.
Ahn S, Maudsley S, Luttrell LM, Lefkowitz RJ, Daaka Y. (1999) Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J Biol Chem. Jan 15;274(3):1185-8.
Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. Jan 29;283(5402):655-61.
Budd, DC, Rae, A, Tobin, AB. (1999) Activation of the mitogen-activated protein kinase pathway by a Gq/11-coupled muscarinic receptor is independent of receptor internalization. J Biol Chem. Apr 30;274(18):12355-60.
Blaukat A, Pizard A, Rajerison RM, Alhenc-Gelas F, Muller-Esterl W, Dikic I. (1999) Activation of mitogen-activated protein kinase by the bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation-triggered internalization. FEBS Lett. May 28;451(3):337-41.
Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ. (1999) Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. J Biol Chem. Jun 4;274(23):15971-4.
Schramm NL, Limbird LE. (1999) Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. J Biol Chem. Aug 27;274(35):24935-40.
Pitcher JA, Tesmer JJ, Freeman JL, Capel WD, Stone WC, Lefkowitz RJ. (1999) Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem. Dec 3;274(49):34531-4.
Kranenburg O, Verlaan I, Moolenaar WH. (1999) Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase. J Biol Chem. Dec 10;274(50):35301-4.
Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Krueger KM, Touhara K, Lefkowitz RJ. (1997) G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. Adv Second Messenger Phosphoprotein Res. 31:263-77. Review.
Luttrell LM, Daaka Y, Lefkowitz RJ. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol. 1999 Apr;11(2):177-83. Review.